Role of bacteriophages in shaping gut microbial community
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Aug. 21, 2024
Phages
are
the
most
diversified
and
dominant
members
of
gut
virobiota.
They
play
a
crucial
role
in
shaping
structure
function
microbial
community
consequently
health
humans
animals.
found
mainly
mucus,
from
where
they
can
translocate
to
intestinal
organs
act
as
modulator
microbiota.
Understanding
vital
phages
regulating
composition
microbiota
influencing
human
animal
is
an
emerging
area
research.
The
relevance
ecosystem
supported
by
substantial
evidence,
but
importance
remains
unclear.
Although
information
regarding
general
phage
ecology
development
has
accumulated,
detailed
knowledge
on
phage-gut
microbe
phage-human
interactions
lacking,
effects
therapy
ambiguous.
In
this
review,
we
systematically
assess
existing
data
environments,
their
development,
possible
interaction,
subsequent
impact
dynamics.
We
discuss
potential
mechanisms
prophage
activation
modulation
bacteria.
also
review
link
between
immune
system
collect
evidence
effect
composition.
Our
will
improve
understanding
influence
facilitate
phage-based
therapies
for
maintaining
healthy
balanced
Language: Английский
A roadmap of isolating and investigating bacteriophage infecting human gut anaerobes
Cong Liu,
No information about this author
Bo Xing,
No information about this author
Zhuoran Li
No information about this author
et al.
Essays in Biochemistry,
Journal Year:
2024,
Volume and Issue:
68(5), P. 593 - 605
Published: Nov. 29, 2024
Bacteriophages,
viruses
that
infect
bacteria,
play
a
crucial
role
in
manipulating
the
gut
microbiome,
with
implications
for
human
health
and
disease.
Despite
vast
amount
of
data
available
on
virome,
number
cultured
phages
bacteria-particularly
obligate
anaerobes-remains
strikingly
limited.
Here,
we
summarize
resources
basic
characteristics
anaerobe.
We
review
various
methods
isolating
these
suggest
strategy
their
isolation.
Additionally,
outline
impact
field
viral
biology,
interactions
bacteria
humans,
potential
disease
intervention.
Finally,
discuss
value
prospects
research
phages,
providing
comprehensive
'Roadmap'
sheds
light
'dark
matter'
anaerobes.
Language: Английский
Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 17, 2024
Bacteriophages
(phages)
and
bacteria
within
the
gut
microbiome
persist
in
long-term
stable
coexistence.
These
interactions
are
driven
by
eco-evolutionary
dynamics,
where
employ
a
variety
of
mechanisms
to
evade
phage
infection,
while
phages
rely
on
counterstrategies
overcome
these
defences.
Among
most
abundant
crAss-like
that
infect
members
Bacteroidales,
particular
Language: Английский