Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study DOI
Binbin Yu,

Guomeng Wan,

Shupeng Cheng

et al.

Current Alzheimer Research, Journal Year: 2023, Volume and Issue: 20(12), P. 875 - 889

Published: Dec. 1, 2023

Background: Alzheimer's Disease (AD) is the most prevalent type of dementia. The early change gut microbiota a potential biomarker for preclinical AD patients. Objective: study aimed to explore changes in characteristics patients, including those with Subjective Cognitive Decline (SCD) and Mild Impairment (MCI), detect correlation between cognitive performances. Methods: This included 117 participants [33 MCI, 54 SCD, 30 Healthy Controls (HC)]. We collected fresh fecal samples blood from all evaluated their performance. analyzed diversity structure through qPCR, screened characteristic microbial species machine learning models, explored correlations these performances serum indicators. Results: Compared healthy controls, MCI SCD patients was significantly different. three microorganisms, Bacteroides ovatus, Bifidobacterium adolescentis, Roseburia inulinivorans, were based on best classification model (HC MCI) having intergroup differences. adolescentis associated better performance multiple scores several inulinivorans showed negative Functional Activities Questionnaire (FAQ). Conclusion: has changed terms composition richness. Correlations have been discovered Gut alterations shown promise affecting pathology deficit.

Language: Английский

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics DOI
Li Chen, Xinyan Wang,

Jiaxin Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139863 - 139863

Published: Jan. 13, 2025

Language: Английский

Citations

1
Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors DOI
Min Qiao, Junjun Ni,

Hong Qing

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1
Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough DOI

Rishabh,

Manni Rohilla, Seema Bansal

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(1), P. 3466 - 3490

Published: May 10, 2024

Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed

Language: Английский

Citations

6
The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease DOI Creative Commons
Junhui Hu,

Baiqing Huang,

Kang Chen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 21, 2024

Introduction Alzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy physical exercise as non-pharmacological intervention to mitigate impacts AD. Methods draws on recent studies that investigate effects neuroinflammation neuronal enhancement in individuals with Results Consistent alters neuroinflammatory pathways, enhances cognitive functions, bolsters brain health among AD patients. It favorably influences activation states microglia astrocytes, fortifies integrity blood-brain barrier, attenuates gut inflammation associated These changes are substantial improvements performance indicators. Discussion The findings underscore potential integrating into comprehensive management strategies. Emphasizing necessity for further research, this advocates refinement regimens maximize their enduring benefits decelerating progression

Language: Английский

Citations

5
The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease DOI Creative Commons
Caroline Ismeurt, Patrizia Giannoni, Florence Servant

et al.

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

ABSTRACT The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis been observed preclinical models Alzheimer’s disease patients. Manipulating composition gut enhances or delays neuropathology deficits mouse models. Accordingly, health status animal facility may strongly influence these outcomes. In present study, we longitudinally analyzed fecal amyloid pathology 5XFAD mice housed specific opportunistic pathogen-free (SOPF) conventional facility. after aging showed marked differences compared to WT littermates that were not when bred SOPF development was also enhanced by housing. We then transplanted (FMT) from both sources into wild-type (WT) measured memory performance, assessed novel object recognition test, animals. Mice with conventionally impaired whereas FMT did induce mice. Finally, 18 weeks housing SOPF-born animals resulted reappearance compositions vs conclusion, results show strong impact conditions on microbiota-associated phenotypes question relevance breeding (SPF) facilities. IMPORTANCE Housing affect microbiota. 6-month-old Alzheimer's is dysbiotic. absent highly sanitized Transfer affects cognition. Microbiota facilities no effect

Language: Английский

Citations

0
Akkermansia muciniphila inhibits jejunal lipid absorption and regulates jejunal core bacteria DOI Creative Commons

Qiming Ma,

Xincheng Zhou,

Wenmei Su

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: 293, P. 128053 - 128053

Published: Jan. 6, 2025

Insufficiency of Akkermansia muciniphila (Akk) has been implicated in the pathogenesis metabolic diseases, and administration or restoration Akk ameliorated these disorders. Recently, Pasteurized (PA-Akk) approved as a functional food. However, impact on lipid absorption proximal intestine, which is directly exposed to orally administered Akk, remains largely unexplored. In this study, we PA-Akk mice investigated subsequent absorption. Long-term resulted reduced deposits liver adipocytes, along with improved glucose metabolism. This was primarily attributed reduction by epithelial cells jejunum. Mechanistically, activated AMP-activated protein kinase (AMPK) inhibit lipids both mouse human jejunal cells. Furthermore, demonstrated that treatment, but not promotes abundance genera are highly abundant normal jejunum belong phylum Firmicutes. Thus, our study concludes oral provides beneficial effects metabolism, partially through inhibiting promoting core microbes.

Language: Английский

Citations

0
Review: New strategies for early dietary intervention in Alzheimer's disease DOI

Jiefu Huang

Nutrition Clinique et Métabolisme, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A–mTOR–HIF1α signaling axis DOI

Chun‐Chieh Peng,

Lei Pan,

Hongying Qi

et al.

Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

ABSTRACT Diabetes is the third most common chronic disorder worldwide. Diabetic wounds are a severe complication that costly and often results in non-traumatic lower limb amputation. Recent investigations have demonstrated gut microbiota as “virtual organ” can regulate metabolic diseases like diabetes. Fecal transplantation (FMT) an innovative therapeutic approach for promoting wound healing, but its function remains incompletely defined. A diabetes model was established by supplying mice with high-fat diet performing intraperitoneal injection of streptozotocin. were then created, followed bacterial transplantation. The relevant indexes healing evaluated to verify effect FMT on diabetic wounds. Human skin keratinocytes also cultured, cell scratch experiments conducted further investigate underlying mechanism. regulated levels specific bacteria helped restore balance intestinal microbes. This enhanced augmenting closure rate, accelerating re-epithelialization, boosting collagen deposition Furthermore, promoted production IL-17A, which significantly growth movement human keratinocytes. Inhibiting molecules related IL-17A–mTOR–HIF1α signaling axis shown hinder re-epithelialization.This study clarifies utilization providing new method target IMPORTANCE Intestinal microbiota, organ largest number microorganisms body, plays crucial role physiological functions body. Normal be involved various such energy absorption, metabolism, immunity imbalance many obesity Diabetes, one world’s three major diseases, significant health issue troubles more than billion people globally. problem all patients must confront when undergoing surgery, it important cause amputations. Exploring wound-healing process offer possibility using means intervene clinically diseases.

Language: Английский

Citations

0
Research Progress of Bile Acids in Neurodegenerative Diseases DOI

念 陈

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

Citations

0
Identification of enterotype for patients with Alzheimer’s disease DOI Creative Commons

G.W. Liu,

Yang Song, Jiangwei Yan

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 10, 2025

Alzheimer's disease (AD) is a progressive and chronic neurodegenerative disorder of the central nervous system, characterized by behavioral dysexecutive deficits. Its pathogenesis closely associated with intestinal flora. This study aimed to explore enterotypes in AD identifying key bacteria through machine learning species co-occurrence network analysis. The collection fecal samples from patients was followed 16 S rRNA analysis using QIIME2. Enterotype clustering conducted at genus level, deep neural (DNN) classification models were developed for healthy controls within each enterotype. Analysis three gut microbiome datasets identified distinct enterotypes: Escherichia_Shigella (ET-E), Faecalibacterium (ET-F), Bacteroides (ET-B). ET-E mainly absence Akkermansia group. significantly positively correlated Eubacterium_coprostanoligenes_group negatively biosynthesis amino acid metabolism. ET-F highly expressed Agathobacter, un_f__Lachnospiraceae, Lachnoclostridium, low Dorea Among them, Agathobacter un_f__Lachnospiraceae Lachnoclostridium. ET-B group had high expression two beneficial bacteria, Butyricicoccus Parabacteroides. findings suggest that enterotype may predispose individuals AD, as potential risk factor. Conversely, appears be milder symptoms, Parabacteroides potentially serving protective factors. Therefore, comprehensive understanding characteristics interactions different essential modulating gut-brain axis mitigating symptoms.

Language: Английский

Citations

0