Fecal microbiota transplantation for the treatment of intestinal and extra‐intestinal diseases: Mechanism basis, clinical application, and potential prospect DOI Creative Commons

Dongxin Yi,

Tao Li,

Yuji Xiao

et al.

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

To review the theoretical basis and therapeutic effects of fecal microbiota transplantation (FMT) in various diseases animal experiments clinical studies, as well limitations current standards FMT application. PubMed Web Science databases were searched for articles published only English between 1975 2023 on reliable results treatment FMT. The properties gut its interactions with host metabolism are critical to human health, microbiome disturbance is closely associated intestinal extra-intestinal diseases. Therefore, tools targeting modulation have attracted increasing attention, among which represents most widely studied intervention strategy. This gathered summarized application diseases, metabolic hypertension, cancer, nervous system arthritis, elaborated beneficial that can be achieved by altering mechanisms action. In addition, potential risks side approach discussed, efforts standardize development Through a systemic outcome mechanism we aimed provide construction an optimized framework, so better exert prospects.

Language: Английский

Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation DOI Open Access
Victòria Ayala,

Laia Fontdevila,

Santiago Rico-Rios

et al.

Sclerosis, Journal Year: 2025, Volume and Issue: 3(1), P. 8 - 8

Published: March 5, 2025

Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The gut microbiota, community microorganisms in digestive tract, has recently been implicated ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. This review explores potential role microbiota metabolites progression investigates therapeutic approaches targeting microbiota. Methods: A comprehensive current literature was conducted to assess relationship between composition, microbial metabolites, patients. We searched for published reports ALS, emphasizing complex interplay dysbiosis, neuroinflammation, systemic metabolism. Special emphasis placed studies exploring short-chain fatty acids (SCFAs), bacterial amyloids (curli-like factors), neurotoxins such as β-methylamino-L-alanine (BMAA). liver–gut axis evaluated well. changes would sustain rationale strategies probiotics, prebiotics, fecal transplantation (FMT), dietary interventions. Results: patients exhibit reduced SCFA-producing bacteria an increase potentially pathogenic genera. Of note, different do not agree common patterns being linked supporting need further, more extensive studies. Dysbiosis sometimes correlates with inflammation disrupted liver function, amplifying neuroinflammatory responses. Key including SCFAs, amyloids, BMAA, may exacerbate neuron promoting protein misfolding, oxidative stress, neuroinflammation. Emerging strategies, probiotics FMT, show restoring balance, although clinical data remain limited. Conclusions: could modulate metabolism ALS. Microbiota-targeted therapies, interventions, represent promising avenues mitigating disease progression. Further research required validate these interventions large-scale, longitudinal develop personalized microbiota-based treatments tailored individual phenotypes.

Language: Английский

Citations

1
Nutritional and Microbiota-Based Approaches in Amyotrophic Lateral Sclerosis: From Prevention to Treatment DOI Open Access

Francesca Cuffaro,

Ingrid Lamminpää, Elena Niccolai

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 102 - 102

Published: Dec. 30, 2024

Metabolic alterations, including hypermetabolism, lipid imbalances, and glucose dysregulation, are pivotal contributors to the onset progression of Amyotrophic Lateral Sclerosis (ALS). These changes exacerbate systemic energy deficits, heighten oxidative stress, fuel neuroinflammation. Simultaneously, gastrointestinal dysfunction gut microbiota (GM) dysbiosis intensify disease pathology by driving immune compromising intestinal barrier, altering gut–brain axis (GBA) signaling, lastly advancing neurodegeneration. Therapeutic preventive strategies focused on nutrition offer promising opportunities address these interconnected pathophysiological mechanisms. Diets enriched with antioxidants, omega-3 fatty acids, anti-inflammatory compounds—such as Mediterranean diet—have shown potential in reducing stress inflammation. Additionally, microbiota-targeted approaches, probiotics, prebiotics, postbiotics, fecal transplantation, emerging innovative tools restore microbial balance, strengthen integrity, optimize GBA function. This review highlights critical need for personalized integrating immunonutrition modulation slow ALS progression, improve quality life, develop measures neurodegenerative neuroinflammatory diseases. Future research should prioritize comprehensive dietary microbiota-based interventions uncover their therapeutic establish evidence-based guidelines managing related disorders.

Language: Английский

Citations

5
Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled trial DOI Creative Commons

Renyi Feng,

Qingyong Zhu, Ao Wang

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 2, 2024

Language: Английский

Citations

4
Gut dysbiosis and leaky gut syndrome in moderately impaired amyotrophic lateral sclerosis patients DOI
Laura Comini, Davide Antonio Di Pietro, Adriana Olivares

et al.

European Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nutritional Interventions in Amyotrophic Lateral Sclerosis: From Ketogenic Diet and Neuroprotective Nutrients to the Microbiota-Gut-Brain Axis Regulation DOI

Samira Nabakhteh,

Amir Lotfi,

Arman Afsartaha

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
The Respiratory Tract Microbiome and Human Health DOI Creative Commons

Patricia Fernández de Córdoba‐Ansón,

Iván Linares‐Ambohades, Fernando Baquero

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(5)

Published: April 28, 2025

ABSTRACT The respiratory tract microbiome (RTM) is a multi‐kingdom microbial ecosystem that inhabits various niches of the system. While previously overlooked, there now sufficient evidence RTM plays crucial role in human health related to immune system training and protection against pathogens. Accordingly, dysbiosis or disequilibrium has been linked several communicable non‐communicable diseases, highlighting need unveil its disease. Here, we define place medicine. Moreover, outline challenges research, emphasising for combining methodologies, including multi‐omics computational tools. We also discuss RTM's potential diagnosing, preventing treating diseases developing novel microbiome‐based therapies improve pulmonary health.

Language: Английский

Citations

0
Fecal microbiota transplantation for the treatment of intestinal and extra‐intestinal diseases: Mechanism basis, clinical application, and potential prospect DOI Creative Commons

Dongxin Yi,

Tao Li,

Yuji Xiao

et al.

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

To review the theoretical basis and therapeutic effects of fecal microbiota transplantation (FMT) in various diseases animal experiments clinical studies, as well limitations current standards FMT application. PubMed Web Science databases were searched for articles published only English between 1975 2023 on reliable results treatment FMT. The properties gut its interactions with host metabolism are critical to human health, microbiome disturbance is closely associated intestinal extra-intestinal diseases. Therefore, tools targeting modulation have attracted increasing attention, among which represents most widely studied intervention strategy. This gathered summarized application diseases, metabolic hypertension, cancer, nervous system arthritis, elaborated beneficial that can be achieved by altering mechanisms action. In addition, potential risks side approach discussed, efforts standardize development Through a systemic outcome mechanism we aimed provide construction an optimized framework, so better exert prospects.

Language: Английский

Citations

0