Hepatocyte‐Derived FGF1 Alleviates Isoniazid and Rifampicin‐Induced Liver Injury by Regulating HNF4α‐Mediated Bile Acids Synthesis DOI Creative Commons

Qian Lin,

Jiaren Zhang, Jie Qi

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Isoniazid and rifampicin co-therapy are the main causes of anti-tuberculosis drug-induced liver injury (ATB-DILI) acute failure, seriously threatening human health. However, its pathophysiology is not fully elucidated. Growing evidences have shown that fibroblast growth factors (FGFs) play a critical role in diverse aspects pathophysiology. The aim this study to investigate FGFs pathogenesis isoniazid (INH) (RIF)-induced injury. Through systematic screening, finds hepatic FGF1 expression significantly downregulated both mouse model patients challenged with INH RIF. Hepatocyte-specific Fgf1 deficiency exacerbates RIF-induced resulted from elevated bile acids (BAs) synthases aberrant BAs accumulation. Conversely, pharmacological administration non-mitogenic analog - FGF1ΔHBS alleviated via restoring homeostasis. Mechanically, repressed hepatocyte nuclear factor 4α (Hnf4α) transcription activating FGF receptor 4 (FGFR4)-ERK1/2 signaling pathway, thus reducing synthase. findings demonstrate functions as negative regulator biosynthesis protect against normalizing homeostasis, providing novel mechanistic insights into ATB-DILI potential therapeutic strategies for treatment ATB-DILI.

Language: Английский

Exploring gut microbial metabolites as key players in inhibition of cancer progression: Mechanisms and therapeutic implications DOI

T. I. Yin,

Xiang Zhang, Yan Xiong

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 288, P. 127871 - 127871

Published: Aug. 8, 2024

Language: Английский

Citations

5
The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis DOI Creative Commons

Yang Shaohui,

Yu Wang,

Lijuan Sheng

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 4, 2025

Abstract Recent studies suggest the role of gut microbes in bile acid metabolism development and progression colorectal cancer. However, surveys association between fecal concentrations cancer (CRC) have been inconsistent. We searched online to identify relevant cross-sectional case-control published major English language databases (Medline, Embase, Web Science, AMED, CINAHL) up January 1, 2024. selected according inclusion exclusion criteria extracted data from them. RevMan 5.3 was used perform meta-analyses. In CRC risk meta-analysis, effect size CA (cholic acid), CDCA (chenodeoxycholic DCA (deoxycholic UDCA (ursodeoxycholic acid) were significantly higher (CA: standardized mean difference [SMD] = 0.41, 95% confidence interval [CI]: 0.5–0.76, P 0.02; CDCA: SMD 0.35, CI: 0.09–0.62, 0.009; DCA: 0.33,95% 0.03–0.64, 0.03; UDCA: 0.46, 0.14–0.78, 0.005), combined high-risk than low-risk group (SMD 0.36, 0.21–0.51, < 0.00001). incidence sizes 0.42, 0.04–0.80, 0.61, 0.26–0.96, 0.00079), their also compared 0.39, 0.09–0.68, 0.01). Only one study suggested a concentration CDCA, DCA, stool group. These findings indicate that may be associated with risk/incidence CRC.

Language: Английский

Citations

0
Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria DOI Creative Commons
Wenwen Ding, Yiwen Cheng, Xia Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Antimicrobial resistance (AMR) has become a major and escalating global health threat, undermining the effectiveness of current antibiotic antimicrobial therapies. The rise multidrug-resistant bacteria led to increasingly difficult-to-treat infections, resulting in higher morbidity, mortality, healthcare costs. Tackling this crisis requires development novel agents, optimization therapeutic strategies, initiatives infection surveillance control. Recent studies highlight crucial role human gut microbiota defending against AMR pathogens. A balanced protects body through mechanisms such as colonization resistance, positioning it key ally fight AMR. In contrast, dysbiosis disrupts defense, thereby facilitating persistence, colonization, dissemination resistant This review will explore how influence drug-resistant bacterial its involvement various types AMR-related potential for microbiota-targeted therapies, fecal transplantation, prebiotics, probiotics, phage therapy. Elucidating interactions between pathogens provide critical insights developing strategies prevent treat infections. While previous reviews have focused on general impact health, specifically look at latest research evolution spread AMR, highlighting strategies.

Language: Английский

Citations

0
The metabolites of gut microbiota: their role in ferroptosis in inflammatory bowel disease DOI Creative Commons
Jingying Zhou,

Peicheng Lu,

Haolong He

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Inflammatory bowel disease (IBD) includes chronic inflammatory conditions, such as Crohn's and ulcerative colitis, characterized by impaired function of the intestinal mucosal epithelial barrier. In recent years, ferroptosis, a novel form cell death, has been confirmed to be involved in pathological process IBD is related various changes, oxidative stress inflammation. Recent studies have further revealed complex interactions between microbiome indicating that ferroptosis an important target for regulation gut microbiota its metabolites. This article reviews significant roles microbial metabolites, short-chain fatty acids, tryptophan, bile IBD. These metabolites participate influencing microenvironment, modulating immune responses, altering levels, thereby exerting impact on development Treatments based are gradually becoming research hotspot. Finally, we discuss potential current therapeutic approaches, including antibiotics, probiotics, prebiotics, fecal transplantation, microbiota, affecting improving symptoms. With deeper understanding interaction mechanisms it expected more precise effective treatment strategies will developed future.

Language: Английский

Citations

0
Honey-Processed Radix Astragali Polysaccharides Exhibit Enhanced Qi-Tonifying Effects via Structural Modifications and Microbiome-Metabolome Regulation DOI
Zhe Lin, Lili Lu, Wenlong Guo

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106560 - 106560

Published: April 1, 2025

Language: Английский

Citations

0
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation DOI Creative Commons
Yousi Fu, Douglas V. Guzior,

Maxwell Okros

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 11, 2025

Conjugated bile acids (BAs) are multi-functional detergents in the gastrointestinal (GI) tract produced by liver enzyme acid-CoA:amino acid N-acyltransferase (BAAT) and microbiome from acyltransferase activity of salt hydrolase (BSH). Humans with inflammatory bowel disease (IBD) have an enrichment both host microbially conjugated BAs (MCBAs), but their impacts on GI inflammation not well understood. We investigated role host-conjugated a mouse model colitis using BAAT knockout background. Baat-/- KO mice severe phenotypes that were rescued supplementation taurocholate (TCA). Gene expression histology showed this rescue was due to improved epithelial barrier integrity goblet cell function. However, metabolomics also TCA resulted extensive metabolism secondary BAs. therefore BSH diverse gut bacteria panel found broad hydrolytic capacity depending bacterium amino conjugate. The complexity microbial BA hydrolysis led exploration bsh genes metagenomic data human IBD patients. Certain sequences enriched people Crohn's particularly Ruminococcus gnavus. This study shows may provide benefits those IBD, is dictated delicate balance between conjugation/deconjugation based present.

Language: Английский

Citations

0
Gut microbiota and epigenetic inheritance: implications for the development of IBD DOI Creative Commons
Xue Guo, Jianhong Li, Jing Xu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 11, 2025

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is considered significant global health concerns worldwide. Many studies have demonstrated that environmental dietary factors influence the gut microbiota, which in turn orchestrates host immune responses. These interactions are also involved complex metabolic processes contribute to pathogenesis of IBD. Furthermore, recent genomics metabolomics unveiled intricate relationship between microbial influencers epigenetics. The dynamics microbiota its metabolites intricately align with DNA methylation, histone lactylation, glycosylation, non-coding RNAs, key players Here, we summarize discuss interplay among epigenetics, factors, their impact on highlight importance multi-omics technologies dissecting host-microbe IBD, potentially offering a framework for developing effective treatment strategies.

Language: Английский

Citations

0
Vinegar-processed frankincense ameliorates ulcerative colitis by targeting BSH-active bacteria preference-mediated GDCA hydrolysis DOI
Wenjie Lu, Zhenli Liu,

Zhiqian Song

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 348, P. 119845 - 119845

Published: April 24, 2025

Language: Английский

Citations

0
Research trends and hotspots of metabolites and inflammatory bowel disease: a bibliometric analysis DOI Creative Commons
J Lyu, Fang Xiao, Keying Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

Purpose The purpose of this study is to analyze the current research status and explore relationship between metabolites inflammatory bowel disease (IBD), providing insights for future research. Methods In study, we retrieved publications on IBD from Web Science Core Collection (WOSCC), covering period 1994 2024. We conducted descriptive visual analyses topics, journals, countries/regions, institutions, authors, citation counts these publications. Results From January June 2024, a total 509 relevant were WOSCC, with number steadily increasing each year. These articles published in 222 top three most productive journals being diseases (36 publications), Alimentary Pharmacology &amp; Therapeutics (16 Digestive Diseases Sciences (13 publications). leading countries publication output China (154 publications, 30.3%), USA (101 19.8%), UK (32 6.3%), 3,175, 7,439, 1,444, respectively. recent trending keywords field include “gut microbiota,” “inflammation,” “pathogenesis.” Conclusion Recent (IBD) has grown significantly, deepening our understanding their connection. Further exploration could not only enhance quality life patients but also offer new into potential cures disease.

Language: Английский

Citations

0
Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5 DOI Open Access

Xiulian Lin,

Li Xia, Yabo Zhou

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4240 - 4240

Published: April 29, 2025

Bile acids and their corresponding intestinal epithelial receptors, the farnesoid X receptor (FXR), G protein-coupled bile acid (TGR5), play crucial roles in physiological pathological processes of cells. These receptors are involved regulation absorption, signal transduction, cellular proliferation repair, senescence, energy metabolism, modulation gut microbiota. A comprehensive literature search was conducted using PubMed, employing keywords such as acid, receptor, FXR (nr1h4), TGR5 (gpbar1), cells, proliferation, differentiation, microbiota, inflammatory bowel disease (IBD), colorectal cancer (CRC), irritable syndrome (IBS), with a focus on publications available English. This review examines diverse effects signaling pathways metabolism Additionally, it explores interactions between acids, well implications these for host health, particularly relation to prevalent diseases. Finally, highlights importance developing highly specific ligands context metabolic disorders.

Language: Английский

Citations

0