Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding mechanistic role gut microbiota-muscle cross-talk sarcopenia, therapeutic implications. The insights encompass causal dysbiosis potentially mediated through microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, their associated signaling pathways, which may be translated into development new microbiome-based treatment diagnostic approaches. Furthermore, identify challenges need addressing future studies to facilitate translation potential novel differential diagnosis older individuals

Language: Английский

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The gut microbiome across the lifespan: how diet modulates our microbial ecosystem from infancy to the elderly

International Journal of Food Sciences and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 19, 2024

This comprehensive review examines the impact of dietary patterns on gut microbiome composition and diversity from infancy to old age, linking these changes age-related health outcomes. It investigates how develops across life stages, focusing influence factors. The explores early-life feeding practices, including breastfeeding formula feeding, shape infant microbiota have lasting effects. In elderly individuals, alterations in are associated with increased susceptibility infections, chronic inflammation, metabolic disorders cognitive decline. critical role diet modulating throughout is emphasised, particularly potential benefits probiotics fortified foods promoting healthy ageing. By elucidating mechanisms connecting food systems health, this provides insights into interventions that could enhance resilience improve outcomes lifespan.

Language: Английский

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The gut microbiome and the brain

Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Purpose of review The importance the gut microbiome for human health and well-being is generally accepted, elucidating signaling pathways between host offers novel mechanistic insight into (patho)physiology multifaceted aspects healthy aging brain functions. Recent findings tightly linked with nervous system, microbiota are increasingly emerging as important regulators emotional cognitive performance. They send receive signals bidirectional communication via immunological, neuroanatomical, humoral pathways. composition spectrum metabolites neurotransmitters that they release changes increasing age, nutrition, hypoxia, other pathological conditions. Changes in (dysbiosis) associated critical illnesses such cancer, cardiovascular, chronic kidney disease but also neurological, mental, pain disorders, well chemotherapies antibiotics affecting development function. Summary Dysbiosis a concomitant imbalance mediators both causes consequences diseases brain. Understanding microbiota’s role pathogenesis these disorders will have major clinical implications offer new opportunities therapeutic interventions.

Language: Английский

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Exercise ameliorates osteopenia in mice via intestinal microbial-mediated bile acid metabolism pathway

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1741 - 1759

Published: Jan. 2, 2025

Rationale: Physical exercise is essential for skeletal integrity and bone health. The gut microbiome, as a pivotal modulator of overall physiologic states, closely associated with homeostasis metabolism. However, the potential role intestinal microbiota in exercise-mediated gain remains unclear. Methods: We conducted depletion fecal transplantation (FMT) ovariectomy (OVX) mice aged to investigate whether transfer ecological traits could confer exercise-induced protective effects. study analyzed metabolic profiles via 16S rRNA gene sequencing LC-MS untargeted metabolomics identify key microbial communities metabolites responsible protection. Transcriptome RNA interference were employed explore molecular mechanisms. Results: found that hindered osteogenic benefits exercise, FMT from exercised osteoporotic effectively mitigated osteopenia. Comprehensive profiling microbiome metabolome revealed exercise-matched reshaped microecology landscape. Notably, alterations bile acid metabolism, specifically enrichment taurine ursodeoxycholic acid, mediated effects on mass. Mechanistically, activated apelin signaling pathway restored bone-fat balance recipient MSCs. Conclusion: Our underscored important microbiota-metabolic axis gain, heralding breakthrough treatment osteoporosis.

Language: Английский

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Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139929 - 139929

Published: Jan. 1, 2025

Language: Английский

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The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1590 - 1590

Published: Feb. 13, 2025

As the world's population continues to age, social patterns are changing, making aging a notable public health challenge. With as major risk factor for cognitive decline, global prevalence of dementia is projected triple in next 25 years. In light growing body evidence involvement microbiota and pathology, its role age-related decline should be explored. Therefore, aim this narrative review thoroughly analyze ways which might affect process decline. Overall, complex phenomenon manifested at systemic, cellular molecular levels. According recent studies, gut composition may influence changes through gut-brain axis. One mechanism involves dysbiosis-related chronic systemic inflammation, leading blood-brain barrier disruption subsequent neuroinflammatory processes. addition inflammaging, induce oxidative stress, another key brain aging. Finally, not only microbiota, but also colonizing oral cavity associated with neurodegenerative diseases.

Language: Английский

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Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults

Phenomics, Journal Year: 2025, Volume and Issue: 5(1), P. 91 - 108

Published: Feb. 1, 2025

Language: Английский

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Branched perfluorohexanesulfonic acid (PFHxS) and perfluoroheptanoic acid (PFHpA): ’Safer’ per- and polyfluoroalkyl substances (PFASs) alternatives for their effects on gut microbiota and metabolic function in children

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109380 - 109380

Published: March 1, 2025

Language: Английский

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COMPARATIVE ANALYSIS OF CONTEMPORARY METHODS FOR INVESTIGATING THE COMPOSITION OF THE HUMAN GUT MICROBIOME

Bulletin of Problems Biology and Medicine, Journal Year: 2025, Volume and Issue: 1(1), P. 373 - 373

Published: Jan. 1, 2025

Language: Английский

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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT Honeybees ( Apis mellifera ), as social insects, exhibit complex behaviors and cognitive functions. The short lifespan stable gut microorganisms of honeybees provide certain availability a rapid high-flux animal model for aging research. This study explored the effect D-galactose, common inducer, on investigated associated effects mechanisms, with particular focus potential protective role sodium butyrate. Experimental cohorts were established follows: conventional (CV) group, D-galactose-treated (DG) butyrate-treated (SB) group. CV group was fed sucrose solution; DG D-galactose SB butyrate solution. A comprehensive assessment conducted day 15 post-treatment, including survival analysis, starvation test, motor, learning memory ability tests, malondialdehyde Smurf test. Potential mechanisms through microbiome metabolome investigated. Compared to from those in showed shortened lifespan, weaker energy storage ability, impaired learning, abilities, reduced weight, increased oxidation, disrupted barrier. These phenotypic changes microbial dysbiosis characterized by Lactobacillus enrichment diminished levels. Notably, supplementation extended honeybees’ improved their abilities damaged D-galactose. Our findings establish valuable system research highlight crucial metabolism senescence regulation. IMPORTANCE presents novel approach investigating processes establishing D-galactose-induced honeybees. demonstrate that effectively attenuates phenotypes, suggesting its therapeutic intervention age-related decline. provides unique studies highlights significant modulating progression. results contribute our understanding molecular underlying offer new insights into anti-aging strategies.

Language: Английский

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