Perspective: Revisiting the Concepts of Prebiotic and Prebiotic Effect in Light of Scientific and Regulatory Progress – A Consensus Paper from the Global Prebiotic Association (GPA)

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(12), P. 100329 - 100329

Published: Oct. 30, 2024

The term prebiotic has been used for almost 3 decades and undergone numerous updates over the years. scientific literature reveals that despite continuous efforts to establish a globally unified definition guide jurisdictional regulations product innovations, ambiguity continues surround terms effect, leading products lack in full regulatory adherence being marketed worldwide. Thus, reflect current state of research knowledge advancement category, an update is warranted. This includes removing selectivity, considering additional locations action besides gut, highlighting performance benefits such as cognitive athletic, providing clear standalone effect. Global Prebiotic Association (GPA) information industry hub committed raising awareness about prebiotics, their emerging well-established health benefits, integrity efficacy. In this position paper, GPA builds on previous definitions propose following expanded prebiotic: "a compound or ingredient utilized by microbiota producing benefit." addition prebiotic, also defines effect benefit arises from alteration composition and/or activity microbiota, direct indirect result utilization specific well-defined microorganisms." With these 2 definitions, aims paint clearer picture incorporating point view, updated may be alongside perspectives move category forward.

Language: Английский

A diverse set of solubilized natural fibers drives structure-dependent metabolism and modulation of the human gut microbiota

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Growing evidence suggests that inadequate dietary fiber intake, termed the “fiber gap,” is linked to disease states through disruption of gut microbiota. Despite this, our understanding how various structures influence microbiota and health limited by lack diverse commercially available fibers. Studies have primarily focused on a range fibers, rather than array fibers representative those commonly found in diets. In this study, we aimed investigate naturally derived impact human their metabolic products. We performed comprehensive structural characterization functional evaluation unique highly set new, soluble with varied monosaccharide compositions, glycosidic linkages, polymer lengths. Using an ex vivo high-throughput platform coupled metabolomic profiling, demonstrate these drive distinct consistent microbial profiles across cohorts donors structure-dependent manner. These effects were accompanied both general donor-specific changes taxa. Finally, integrating detailed glycomic data allowed for prediction outcomes driven novel material, pineapple pulp fiber. This work highlights potential targeted interventions modulate improve outcomes, paving way development new fiber-rich products specific benefits. IMPORTANCE Fiber deficiency associated numerous states, many which are study encompasses first systematic collection solubilized impacts The results expand beneficial carbohydrate diet, highlighting designing fiber-based interventions. high solubility increases they can be incorporated as well assayability experiments, enabling widespread increase consumption positive impacts.

Language: Английский