Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.
Language: Английский
Citations
1Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422
Published: Feb. 10, 2025
The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.
Language: Английский
Citations
1Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment
Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2876 - 2876
Published: Aug. 19, 2024
Pancreatic cancer demonstrates an ever-increasing incidence over the last years and represents one of top causes cancer-associated mortality. Cells tumor microenvironment (TME) interact with cells in pancreatic ductal adenocarcinoma (PDAC) tumors to preserve cells' metabolism, inhibit drug delivery, enhance immune suppression mechanisms finally develop resistance chemotherapy immunotherapy. New strategies target TME genetic alterations specific pathways cell populations TME. Complex molecular interactions between PDAC including fibroblasts, myeloid-derived suppressor cells, stellate tumor-associated macrophages, neutrophils, regulatory T cells. In present review, we aim fully explore landscape discuss current targeting provide thoughts for further research preclinical testing.
Language: Английский
Citations
4Advancing Targeted Therapies in Pancreatic Cancer: Leveraging Molecular Aberrations for Therapeutic Success
Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0Inflammation, microbiota, and pancreatic cancer
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 22, 2025
Pancreatic cancer (PC) is a malignancy of gastrointestinal tract threatening the life people around world. In spite advances in treatment PC, overall survival this disease advanced stage less than 12%. Moreover, PC cells have aggressive behaviour proliferation and metastasis as well capable developing therapy resistance. Therefore, highlighting underlying molecular mechanisms pathogenesis can provide new insights for its treatment. present review, inflammation related pathways role gut microbiome regulation are highlighted. The various kinds interleukins chemokines able to regulate angiogenesis, metastasis, proliferation, resistance cells. Furthermore, number including NF-κB, TLRs TGF-β demonstrate dysregulation aggravating tumorigenesis. Therapeutic these reverse progression PC. Both chronic acute pancreatitis been shown be risk factors development further inflammation. Finally, composition microbiota factor through affecting such NF-κB mediate
Language: Английский
Citations
0Inflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition
Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 361 - 361
Published: Feb. 28, 2025
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand bacterial changes accompanying PDAC promotion progression stimulated by inflammation fecal transplantation (FMT), we investigated stool 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions KrasG12D, age- sex-matched control that were exposed to inflammatory stimuli obtained from PDAC. Time- inflammatory-dependent composition alterations alpha diversity reduction observed only a Kras mutation developed advanced changes. Stool Actinobacteriota abundance Bifidobacterium abundances increased. In contrast, Firmicutes, Verrucomicrobiota, Spirochaetota, Desulfobacterota, Butyricicoccus, Roseburia, Lachnospiraceae A2, unclassified, Oscillospiraceae unclassified decreased, detection Alloprevotella uncultured was not observed. Furthermore, FMT accelerated tumorigenesis, gradually decreased diversity, changed microbial mutation. Specifically, Actinobacteriota, Faecalibaculum increased, while genera such as Lachnospiraceace A2 ASF356, Desulfovibrionaceace uncultured, Roseburia decreased. conclusion, carcinogenesis presence an oncogenic chronic dynamically pancreas microbiota. particular, decrease bacteria known be involved short-fatty acids production mouse model can used for further research on microbiota-PDAC interactions towards more personalized effective cancer therapies.
Language: Английский
Citations
0Optimizing Cancer Treatment Through Gut Microbiome Modulation
Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1252 - 1252
Published: April 7, 2025
The gut microbiome plays a pivotal role in modulating cancer therapies, including immunotherapy and chemotherapy. Emerging evidence demonstrates its influence on treatment efficacy, immune response, resistance mechanisms. Specific microbial taxa enhance checkpoint inhibitor while dysbiosis can contribute to adverse outcomes. Chemotherapy effectiveness is also influenced by composition, with engineered probiotics prebiotics offering promising strategies drug delivery reduce toxicity. Moreover, metabolites, such as short-chain fatty acids, systems have shown potential improve therapeutic responses. These findings underscore the importance of personalized microbiome-based approaches optimizing treatments.
Language: Английский
Citations
0Molecular and cellular mechanisms of PDAC progression based on RETN-CAP1-mediated macrophage-fibroblast crosstalk: Action of ITGB5 and ITGB1 recombinant proteins
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 290, P. 139078 - 139078
Published: Dec. 22, 2024
Language: Английский
Citations
0Priming the Nutrition-Gut-Immuno-Oncology Axis
Published: Jan. 1, 2024
Language: Английский
Citations
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