Gut,
Journal Year:
2025,
Volume and Issue:
unknown, P. gutjnl - 333397
Published: Feb. 17, 2025
The
link
between
gut
microbiome
and
eating
behaviours,
especially
palatable
food
intake,
is
a
growing
focus
of
scientific
investigation.
complex
ecosystem
microorganisms
in
the
influences
host
metabolism,
immune
function
neurobehavioural
signalling.
This
review
explores
role
neuroinflammation
dysregulations
food-induced
reward
signalling
potential
causal
microbiota
on
these
proinflammatory
processes.
Particular
attention
given
to
disorders
(ED,
specifically
anorexia
nervosa,
binge
disorder
bulimia
nervosa)
links
with
microbiota,
alterations
neuroinflammation.
Finally,
we
propose
modulation
as
promising
therapeutic
strategy
ED.
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 159 - 159
Published: Feb. 6, 2025
Parkinson's
disease
is
recognized
as
the
second
most
prevalent
neurodegenerative
disorder
globally,
with
its
incidence
rate
projected
to
increase
alongside
ongoing
population
growth.
However,
precise
etiology
of
remains
elusive.
This
article
explores
inflammatory
mechanisms
linking
gut
microbiota
disease,
emphasizing
alterations
in
and
their
metabolites
that
influence
disease's
progression
through
bidirectional
transmission
signals
along
gut-brain
axis.
Building
on
this
mechanistic
framework,
further
discusses
research
methodologies
treatment
strategies
focused
metabolites,
including
metabolomics
detection
techniques,
animal
model
investigations,
therapeutic
approaches
such
dietary
interventions,
probiotic
treatments,
fecal
transplantation.
Ultimately,
aims
elucidate
relationship
between
underlying
thereby
paving
way
for
novel
avenues
condition.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 722 - 722
Published: Feb. 5, 2025
There
has
been
no
chemical
analysis
of
the
fruit
medicinal
plant
Jatropha
podagrica
until
now.
The
current
study
aimed
to
qualitatively
and
quantitatively
analyze
J.
using
a
high-resolution
LC-MS
strategy,
i.e.,
library-comparison
ultra-high-performance
liquid
chromatography-Quadrupole-Orbitrap-tandem
mass
spectrometry.
strategy
putatively
identified
46
compounds
from
fresh
fruit.
During
putative
identification,
10
isomers
(e.g.,
(vitexin
vs.
isovitexin)
were
completely
distinguished
each
other.
Thereafter,
all
simultaneously
quantified
authentic
standard
comparison
method.
Finally,
they
also
subjected
2,2′-azino
bis
(3-ethylbenzothiazolin-6-sulfonic
acid
radical
(ABTS+•)-scavenging
assay
characterize
their
relative
antioxidant
capacities.
Their
capacities
thus
multiplied
by
contents
calculate
contribution
values,
respectively.
Corilagin,
gallic
acid,
ellagic
phillygenin
exhibited
highest
percentages
thereby
suggested
as
four
top
contributors.
are
recommended
build
up
quality-markers
(Q-markers)
system
fruits.
All
these
findings
can
help
develop
fruits
potential
resource
natural
medicine.
Molecular Metabolism,
Journal Year:
2025,
Volume and Issue:
93, P. 102109 - 102109
Published: Feb. 6, 2025
There
is
growing
evidence
that
sleep
deprivation
promotes
cancer
progression.
In
addition,
colon
patients
often
experience
due
to
factors
such
as
pain
and
side
effects
of
treatment.
The
occurrence
liver
metastases
an
important
factor
in
the
mortality
patients.
However,
relationship
between
from
has
not
been
elucidated.
A
metastasis
model
was
constructed
evaluate
effect
on
cancer.
Subsequently,
mice
feces
were
collected
for
untargeted
metabolomics
screen
identify
key
mediator,
Kynurenic
acid
(KynA).
Furthermore,
HILPDA
screened
by
transcriptomics,
its
potential
mechanism
explored
through
ChIP,
co-IP,
ubiquitination
experiments,
phenotyping
etc.
RESULTS:
Sleep
Functionally,
aggravates
lipid
accumulation
decreases
production
microbiota
metabolite
KynA.
contrast,
KynA
inhibited
progression
vitro.
vivo,
supplementation
reversed
promoting
Mechanistically,
downregulates
expression
P4HA2
promote
degradation
HIF-1α,
which
leads
a
decrease
transcription
HILPDA,
ultimately
increase
lipolysis
cells.
Our
findings
reveal
impairs
intracellular
KynA,
leading
droplets
This
process
metastasis.
suggests
promising
strategy
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Feb. 1, 2025
ABSTRACT
Ulcerative
colitis
is
a
chronic
inflammatory
disease
characterized
by
oxidative
stress
and
the
production
of
pro‐inflammatory
cytokines.
Ferulic
acid
quinic
acid,
two
phenolic
compounds,
are
thought
to
have
potent
antioxidant
anti‐inflammatory
properties.
This
study
aimed
investigate
effects
ferulic
in
rats
with
acetic
(AA)‐induced
ulcerative
colitis.
To
this
end,
64
Wistar
were
randomly
divided
into
eight
groups,
each
consisting
rats.
AA
was
administered
intrarectally
induce
(20,
40,
60
mg/kg),
(10,
30,
60,
100
dexamethasone
(2
mg/kg)
received
daily
for
five
consecutive
days.
Then,
macroscopic
histopathological
changes
colon
tissue
examined.
Finally,
levels
heme
oxygenase
1
(HO1),
nuclear
factor
erythroid
2‐related
2
(NRF2),
NAD(P)H
quinone
dehydrogenase
(NQO1)
mRNA
expression
cytokine
tumor
necrosis
alpha
(TNF‐α)
interleukin‐1
beta
(IL‐1β)
measured
using
quantitative
real‐time
polymerase
chain
reaction
(PCR)
enzyme‐linked
immunosorbent
assay
(ELISA)
methods,
respectively.
AA‐induced
associated
edema
severe
damage
epithelium,
infiltration
cells,
presence
ulcers
tissue.
The
results
showed
that
who
decrease
HO‐1,
Nrf2,
NQO1
increased
protein
TNF‐α
IL‐1β
than
control
group.
Rats
and,
significantly
improved
indices.
upregulated
mg/kg
and100
treatment
compared
dose‐dependently
decreased
effectively
reduce
inflammation
mucosal
colitis,
especially
when
high
doses.
possible
mechanism
response
may
involve
activating
Nrf2/HO‐1
pathway.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 317 - 317
Published: March 1, 2025
Background:
Acne
is
a
prevalent
dermatological
condition
characterized
by
the
blockage
of
hair
follicles
and
sebaceous
glands,
leading
to
formation
acne.
The
anaerobe
pathogen
Cutibacterium
acnes
(formerly
known
as
Propionibacterium
acnes)
plays
an
essential
role
in
pathogenesis
acne,
for
which
generally
antimicrobial
treatment
required.
substantial
health
concern,
continuing
research
being
conducted
discover
novel
efficacious
remedies.
activity
plants
has
been
demonstrated
numerous
studies,
they
are
still
targeted
organisms
drug
development.
Studies
showing
that
effective
against
acne
pathogens
have
also
reported.
Methods:
hydroethanolic
extracts
prepared
from
30
plant
species
was
determined
C.
standard
strains
(C.
Scholz
Kilian
ATCC
11827
11828)
clinical
isolates
our
preliminary
screening.
Since
inflammatory
skin
disease,
anti-inflammatory
effect
six
active
through
vitro
inhibition
collagenase,
lipoxygenase
(LOX),
hyaluronidase
xanthine
oxidase
(XO)
enzymes.
Results:
Cotinus
coggygria
Scop.
leaf
extract
displayed
highest
collagenase
(79.75%
52.52%,
respectively),
while
aerial
parts
Helichrysum
arenarium
(L.)
Moench
potent
XO
inhibitory
(82.51%).
Therefore,
these
two
chosen
further
LC/MS-MS
used
determine
phenolic
profiles
extracts.
Conclusions:
Subsequently,
nanoemulgels
were
formulated
with
develop
prototype
herbal
anti-acne
product,
characterization
studies
formulations
conducted.
Abstract
Neuroinflammation,
a
key
defense
mechanism
of
the
nervous
system,
is
associated
with
changes
in
inflammatory
markers
and
stimulation
neuroimmune
cells
such
as
microglia
astrocytes.
Growing
evidence
indicates
that
gut
microbiota
its
metabolites
directly
or
indirectly
regulate
host
health.
According
to
recent
studies,
bacterial
dysbiosis
closely
linked
several
central
system
disorders
cause
neuroinflammation,
including
multiple
sclerosis,
Alzheimer's
disease,
Parkinson's
sepsis‐associated
encephalopathy,
ischemic
stroke.
Recent
findings
indicate
bidirectional
communication
network
between
influences
neuroinflammation
cognitive
function.
Dysregulation
this
can
affect
generation
cytotoxic
metabolites,
promote
impair
cognition.
This
review
explores
lesser‐studied
microbiota‐derived
involved
neuroinflammation—bile
acids,
trimethylamine‐N‐oxide,
indole
derivatives—as
targets
for
creating
new
treatment
tools
neuroinflammatory
illnesses,
well
possible
biomarkers
early
diagnosis
prognosis.
