The perinatal microbiota-gut-brain axis: Implications for postpartum depression

NeuroImmunoModulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 21, 2025

Background: Pregnancy and childbirth are accompanied by widespread maternal physiological adaptations hormonal shifts, that have been suggested to result in a period of vulnerability for the development mood disorders such as postpartum depression (PPD). There is also evidence peripartum changes composition gut microbiota, but potential contribution intestinal microbes adaptations, or subsequent vulnerabilities, during this unknown. Summary: Here we outline key pathways involved including GABAergic signaling, oxytocin immunomodulation associated with susceptibility present these modulated microbes. We discuss therapeutic microbiota-gut-brain axis identify future directions research help realize potential. Key Messages: Peripartum shifts microbial composition. Disruption GABAergic, immunomodulatory may contribute depression. These adaptative suggesting role microbiota determining PPD. More needed confirm relationship PPD gain mechanistic understanding required disorder.

Language: Английский

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The neonatal gut microbiome in health and disease

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 27, 2025

Language: Английский

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Mikrobiom im Fokus: Braucht es einen Paradigmenwechsel in der Geburtshilfe?

Hebamme, Journal Year: 2025, Volume and Issue: 38(01), P. 25 - 33

Published: Feb. 1, 2025

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Disruption and adaptation: infant gut microbiota’s dynamic response to SARS-CoV-2 infection

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 11, 2025

The responses of the infant gut microbiota to infection significantly disrupt natural intrahost evolutionary processes microbiome. Here, we collected a 16-month longitudinal cohort microbiomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Then, developed multicriteria approach identify core interaction network driving community dynamics under environmental disturbances, which termed Conserved Variated Interaction Group (CVIgroup). CVIgroup showed significant advantages on pinpointing sparse set associated with as validated both our own and publicly available datasets. Leveraging Oxford Nanopore Technology, found this group facilitates ecosystem's adaptation disruptions enhancing mobility mobile genetic elements, including reinforcement twin-arginine translocation pathway in response increased virulence factors. Furthermore, serves an effective indicator ecosystem health. timescale for microbiota's extends beyond 10 months. Members CVIgroup, such Bacteroides thetaiotaomicron Faecalibacterium, exhibit varying degrees genomic structural variants, contribute guiding toward new stable state rather than returning its original configuration. Collectively, offers snapshot adaptive disturbances. disruption subsequent infants after COVID-19 underscores necessity re-evaluating reference standards context post-pandemic era.

Language: Английский

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Neonatal Food Protein-Induced Enterocolitis: Current Insights and Knowledge Gaps

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2461 - 2461

Published: April 3, 2025

Acute and chronic Food Protein-Induced Enterocolitis Syndrome (FPIES) has been well characterized in children; otherwise, neonatal FPIES (N-FPIES) remains poorly understood. In terms of pathophysiology, appears to have a more prevalent TH2 response is by specific clinical features that make the diagnosis challenging. Genetic environmental risk factors may predispose development FPIES. Recent evidence indicates characteristic microbiota signature lead barrier dysfunction, reduced regulatory T cells, abnormal intestinal production serotonin, responsible for symptoms Regarding presentation, newborns with not fully meet current guideline's diagnostic criteria at disease onset, being similar entity age than acute infants children. Hence, differentiation from other medical surgical conditions-particularly necrotizing enterocolitis (NEC)-remains critical challenge clinicians. This present review highlights our understanding N-FPIES, term presentation diagnosis, treatment strategies. Refining N-FPIES represents priority help physicians diagnosing managing this challenging condition. Last, but least, larger trials are needed optimize practices preterm

Language: Английский

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A Comprehensive Atlas of Multi-Tissue Metabolome and Microbiome Shifts: Exploring Obesity and Insulin Resistance Induced by Perinatal Bisphenol S Exposure in High-Fat Diet-Fed Offspring

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136895 - 136895

Published: Dec. 15, 2024

Language: Английский

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