Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem DOI Creative Commons
Ellen L. Zechner, Sabine Kienesberger

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 18, 2024

The human intestinal tract is densely colonized by a microbial community that subject to intense competition. Bacteria in this complex habitat seek outcompete their neighbors for nutrients and eliminate competitors with antibacterial toxins. Antagonism can be mediated diverse effectors including toxic proteins small molecule inhibitors are released extracellularly or delivered specialized secretion systems targeted cells. Two prototypical microbiota-derived enterotoxins, colibactin tilimycin, the newly discovered family of indolimines represent an expanding group non-proteinaceous molecules which specifically target DNA. In addition cell killing, they generate mutations genome instability intoxicated microbes host cells alike. They have been studied detail because direct toxicity important etiological roles pathologies. Increasing evidence, however, reveals these commensal genotoxins also mediators interbacterial antagonism, impacts gut ecology. review, we illustrate functional versatility ecosystem.

Language: Английский

Intratumoral Microbiota: Insights from Anatomical, Molecular, and Clinical Perspectives DOI Open Access
Claudia Lombardo, Rosario Fazio,

Marta Sinagra

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(11), P. 1083 - 1083

Published: Oct. 31, 2024

The human microbiota represents a heterogeneous microbial community composed of several commensal, symbiotic, and even pathogenic microorganisms colonizing both the external internal body surfaces. Despite term "microbiota" being commonly used to identify inhabiting gut, pieces evidence suggest presence different physiologically other organs. In this context, studies have also confirmed that microbes are integral components tumor tissue in types cancer, constituting so-called "intratumoral microbiota". intratumoral is closely related occurrence development cancer as well efficacy anticancer treatments. Indeed, can contribute carcinogenesis metastasis formation some directly cause DNA damage, while others induce activation proinflammatory responses or oncogenic pathways alter microenvironment (TME). All these characteristics make an interesting topic investigate for diagnostic prognostic purposes order improve management patients. This review aims gather most recent data on role development, progression, response treatment, its potential value.

Language: Английский

Citations

2
Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem DOI Creative Commons
Ellen L. Zechner, Sabine Kienesberger

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 18, 2024

The human intestinal tract is densely colonized by a microbial community that subject to intense competition. Bacteria in this complex habitat seek outcompete their neighbors for nutrients and eliminate competitors with antibacterial toxins. Antagonism can be mediated diverse effectors including toxic proteins small molecule inhibitors are released extracellularly or delivered specialized secretion systems targeted cells. Two prototypical microbiota-derived enterotoxins, colibactin tilimycin, the newly discovered family of indolimines represent an expanding group non-proteinaceous molecules which specifically target DNA. In addition cell killing, they generate mutations genome instability intoxicated microbes host cells alike. They have been studied detail because direct toxicity important etiological roles pathologies. Increasing evidence, however, reveals these commensal genotoxins also mediators interbacterial antagonism, impacts gut ecology. review, we illustrate functional versatility ecosystem.

Language: Английский

Citations

2