The Role of the Gastrointestinal Microbiota in Parkinson’s Disease DOI Creative Commons
Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 26 - 26

Published: Dec. 28, 2024

Background/Objectives: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons leading to debilitating motor and non-motor symptoms. Beyond its well-known neurological features, emerging evidence underscores pivotal role gut–brain axis gastrointestinal microbiota in PD pathogenesis. Dysbiosis has been strongly linked associated with increased intestinal permeability, chronic inflammation, production neurotoxic metabolites that may exacerbate neuronal damage. Methods: This review delves into complex interplay between dysbiosis, shedding light on two peculiar subsets Helicobacter pylori infection small-intestinal bacterial overgrowth. These conditions not only contribute progression but also influence therapeutic responses such as L-dopa efficacy. Conclusions: The potential modulate gut through probiotics, prebiotics, synbiotics; fecal transplantation; antibiotics represents promising frontier for innovative treatments. Despite this potential, current limited small sample sizes methodological variability across studies. Rigorous, large-scale, randomized placebo-controlled trials standardized treatments terms composition, dosage, duration are urgently needed validate these findings pave way microbiota-based strategies management.

Language: Английский

Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma DOI Creative Commons
Yanguang Yang, Xinli Shi

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Language: Английский

Citations

1
Levying evidence of the impact of Triphala in the mildly constipated human colon microbiota DOI Creative Commons
Elizabeth Goya‐Jorge, Pauline Bondue, Irma Gonza

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

Citations

0
Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression DOI

Jianzhong Shu,

Yu-Han Huang,

Xiaohong He

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 25, 2025

In the current era, metabolic dysfunction-associated steatotic liver disease (MASLD) has gradually developed into a major type of chronic that is widespread globally. Numerous studies have shown gut microbiota plays crucial and indispensable role in progression MASLD. Currently, become one important entry points for research this disease. Therefore, aim review to elaborate on further associations between MASLD, including changes differences healthy diseased liver. Meanwhile, considering fatty steatohepatitis are abnormal pathological states development exhibits different degrees fibrosis (such as mild severe fibrosis) during progression, we also conduct comparison these use them markers progression. It reveals production action mechanisms short-chain acids bile brought about by microbiota, impact lipopolysaccharide from Gram-negative bacteria addition, regulation inhibition related factors probiotics (including new-generation probiotics) will be explored, which help monitor patients with compositions future carry out personalized targeted therapies microbiota. This achieve progress preventing combating

Language: Английский

Citations

0
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis DOI Open Access
Xiaoxin Jiang, Jingyi Ren,

Gejun Yu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1174 - 1174

Published: March 28, 2025

Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colorectum, posing significant global health burden. Recent studies highlight critical role of gut microbiota and its metabolites, particularly bile acids (BAs), in UC's pathogenesis. The relationship between BAs bidirectional: influence BA composition, while regulate diversity activity through receptors like Farnesoid X receptor (FXR) Takeda G protein-coupled 5 (TGR5). Targeting bile-acid metabolism to reshape presents promising therapeutic strategy for UC. This review examines classification synthesis BAs, their interactions with microbiota, potential nutritional microbial interventions. By focusing on these therapies, we aim offer innovative approaches effective UC management.

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0
The association between the health of the intestines and the human body with Akkermansia muciniphila DOI Creative Commons

Seyed Ali Sadr Tabatabaei,

Hedie Yousefi Ghadim,

Sara Alaei

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100352 - 100352

Published: April 1, 2025

Language: Английский

Citations

0
Persister Intestinal Bacteria, Epigenetics and Major Depression DOI Creative Commons
Luis Vitetta, Matthew Bambling, Esben Strodl

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(4)

Published: March 31, 2025

The microbiota-gut-brain axis has been proposed as a potential modulator of mood disorders such major depression. Complex bidirectional biochemical activities in this have posited to participate adverse disorders. Environmental and genetic factors dominated recent discussions on prescription antibiotics, antidepressants, negative DNA methylation reactions dysbiotic gut microbiome cited causal for the development progression While research continues investigate microbiome-gut-brain axis, review will explore state persistence bacteria that underpins bacterial dormancy, possibly due environmental conditions and/or pharmaceutical prescriptions. Bacterial dormancy intestinal microbial cohort could affect role epigenomes methylations. methylations are highly motif driven exerting significant control phenotypes can disrupt metabolism neurotransmitter formation gut, outcomes support dispositions.

Language: Английский

Citations

0
The Role of the Gastrointestinal Microbiota in Parkinson’s Disease DOI Creative Commons
Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Maria Assunta Zocco

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 26 - 26

Published: Dec. 28, 2024

Background/Objectives: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons leading to debilitating motor and non-motor symptoms. Beyond its well-known neurological features, emerging evidence underscores pivotal role gut–brain axis gastrointestinal microbiota in PD pathogenesis. Dysbiosis has been strongly linked associated with increased intestinal permeability, chronic inflammation, production neurotoxic metabolites that may exacerbate neuronal damage. Methods: This review delves into complex interplay between dysbiosis, shedding light on two peculiar subsets Helicobacter pylori infection small-intestinal bacterial overgrowth. These conditions not only contribute progression but also influence therapeutic responses such as L-dopa efficacy. Conclusions: The potential modulate gut through probiotics, prebiotics, synbiotics; fecal transplantation; antibiotics represents promising frontier for innovative treatments. Despite this potential, current limited small sample sizes methodological variability across studies. Rigorous, large-scale, randomized placebo-controlled trials standardized treatments terms composition, dosage, duration are urgently needed validate these findings pave way microbiota-based strategies management.

Language: Английский

Citations

0