Protective Effect of Dietary Fiber on Blood Pressure and Vascular Dysfunction Through Regulation of Sympathetic Tone and Immune Response in Genetic Hypertension DOI Open Access
Cristina González‐Correa, Javier Moleón, Sofía Miñano

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT The mechanisms underlying the antihypertensive effect of dietary fibers remain poorly understood. This study investigates whether fiber supplementation can prevent cardiovascular damage and high blood pressure in a genetic model neurogenic hypertension. Six‐week‐old male spontaneously hypertensive rats (SHR) their respective normotensive control, Wistar Kyoto (WKY), were divided into four groups: Untreated WKY, untreated SHR, SHR treated with resistant starch (SHR + RS), inulin‐type fructans ITF) for 12 weeks. Additionally, faecal microbiota transplantation (FMT) experiment was conducted, transferring content from donors to recipient SHRs. A diet rich RS reduced vascular oxidative stress, inflammation, pressure. These protective effects associated reshaped gut microbiota, leading increased short‐chain fatty acid production, endotoxemia, decreased sympathetic activity, restored balance between Th17 Treg lymphocytes mesenteric lymph nodes aorta. Elevated plasma levels acetate butyrate group correlated expression aortic GPR41, GRP43 PPARδ. Conversely, ITF treatment failed hypertension or endothelial dysfunction SHR. FMT partially replicated these beneficial effects. highlights benefits insoluble fiber, which are attributed enhanced acids production gut. leads improved permeability, tone, diminished T‐cell accumulation. Therefore, interventions may offer promising therapeutic strategies preventing

Language: Английский

Protective Effect of Dietary Fiber on Blood Pressure and Vascular Dysfunction Through Regulation of Sympathetic Tone and Immune Response in Genetic Hypertension DOI Open Access
Cristina González‐Correa, Javier Moleón, Sofía Miñano

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT The mechanisms underlying the antihypertensive effect of dietary fibers remain poorly understood. This study investigates whether fiber supplementation can prevent cardiovascular damage and high blood pressure in a genetic model neurogenic hypertension. Six‐week‐old male spontaneously hypertensive rats (SHR) their respective normotensive control, Wistar Kyoto (WKY), were divided into four groups: Untreated WKY, untreated SHR, SHR treated with resistant starch (SHR + RS), inulin‐type fructans ITF) for 12 weeks. Additionally, faecal microbiota transplantation (FMT) experiment was conducted, transferring content from donors to recipient SHRs. A diet rich RS reduced vascular oxidative stress, inflammation, pressure. These protective effects associated reshaped gut microbiota, leading increased short‐chain fatty acid production, endotoxemia, decreased sympathetic activity, restored balance between Th17 Treg lymphocytes mesenteric lymph nodes aorta. Elevated plasma levels acetate butyrate group correlated expression aortic GPR41, GRP43 PPARδ. Conversely, ITF treatment failed hypertension or endothelial dysfunction SHR. FMT partially replicated these beneficial effects. highlights benefits insoluble fiber, which are attributed enhanced acids production gut. leads improved permeability, tone, diminished T‐cell accumulation. Therefore, interventions may offer promising therapeutic strategies preventing

Language: Английский

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