Intestinal microbiota distribution and changes in different stages of Parkinson's disease: A meta-analysis, bioinformatics analysis and <i>in vivo</i> simulation

BioScience Trends, Journal Year: 2025, Volume and Issue: 19(1), P. 87 - 101

Published: Jan. 24, 2025

Parkinson's disease (PD) is a progressive that requires effective staging management. The role of intestinal microbiota in PD has been studied, but its changes at different stages are not clear. In this study, meta- analysis, bioinformatics analysis and vivo simulation were used to explore the distribution patients models stages. Two established rotenone-treated rats MPTP-induced mice. differences among or compared analyzed. There significant between controls, including Actinobacteriota, Deltaproteobacteria, Clostridiales, Lachnospiraceae, Parabacteroides, etc. Through we revealed Methanobacteria, Erysipelotrichales, Prevotellaceae, Parabacteroides gordonii, meta-analysis, found Actinobacteriota Erysipelotrichaceae had significantly increased chronic MPTP model, while Prevotellaceae decreased. mice presented damage motor function, coordination, autonomous activity ability gastrointestinal late group was greater than early group. control groups. stage, dominant Akkermansia, Alistipes, Anaerotruncus, Bilophila, Rikenellaceae, Verrucomicrobia Verrucomicrobiae, whereas Erysipelotrichaceae. These can lay foundation for subsequent research on treatment mechanism

Language: Английский

Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский