Size-dependent ecotoxicological impacts of tire wear particles on zebrafish physiology and gut microbiota: implications for aquatic ecosystem health

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137215 - 137215

Published: Jan. 16, 2025

Language: Английский

Bacterial viability retention in probiotic foods: a review

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 11, 2025

Probiotics offer substantial health benefits, leading to their increased consumption in various food products. The viability of probiotics is a critical factor that influences the nutritional and therapeutic efficacy these foods. However, as often lose during production oral administration, effective preservation encapsulation technologies are needed overcome this challenge. This review elucidates diverse sources incorporation strategies probiotics, while systematically analyzing effects water transformation (ice front velocity, glass transition temperature, collapse temperature), processing conditions (food matrix, dissolved oxygen), gastrointestinal challenges (gastric fluid, digestive enzymes, bile salts) on probiotic viability. Effective strengthen encompass three primary domains: fermentation processes, techniques, methods. Specifically, include meticulous control (nitrogen sources, lipids, carbon sources), pre-stress treatments (pre-cooling, heat shock, NaCl stress, acid stress), optimized lyoprotectant selection (carbohydrates, proteins, polyols), synergistic freeze-drying (infrared technology, spray drying, microwave), bulk approaches (polysaccharide or protein-based microencapsulation), single-cell methods (self-assembly surface functionalization). Despite advancements, targeting specific matrices remains challenging, necessitating further research enhance

Language: Английский

Coix Seed Oil Alleviates Hyperuricemia in Mice by Ameliorating Oxidative Stress and Intestinal Microbial Composition

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1679 - 1679

Published: May 15, 2025

Background: Coix seed oil (YRO), rich in unsaturated fatty acids, has emerged as a promising intervention for hyperuricemia (HUA) due to its potential alleviate oxidative damage and support organ health. Methods: The acid composition of YRO was determined by gas chromatography–mass spectrometry (GC-MS). A HUA mouse model established, serum markers hepatic enzymes were evaluated. Renal mitochondrial function assessed using immunohistochemistry immunofluorescence, urate transporter expression, along with key signaling proteins, quantified Western blot analysis. Additionally, gut microbiota analyzed, non-targeted metabolomics performed observe alterations lipid metabolites. Results: significantly reduced uric (UA) levels normalized enzyme activities. Histological evaluation revealed less tissue both the kidney intestine. In kidney, improved supported antioxidant defenses via regulation Keap1/Nrf2 signaling. intestine, enhanced barrier integrity increasing ZO-1, Occludin, Claudin-1 expression. Moreover, modulated beneficial bacteria (Muribaculaceae, Prevotellaceae UCG-001, Lachnospiraceae_ NK4A136_group, Akkermansia) while suppressing harmful species (Bacteroides, Dubosiella). Lipid indicated restoration phospholipid balance through modulation PI3K/AKT/mTOR pathway. Conclusions: metabolic health promoting UA homeostasis, enhancing function, reinforcing capacity, maintaining integrity. These findings suggest that coix could serve nutritional supplement managing related disturbances.

Language: Английский