The Crucial Role of Vitamin D in Regulating Gut Microbiota in Inflammatory Bowel Disease DOI
Alessia Bartolacci, Fabrizio Stocchi, Vilberto Stocchi

et al.

Recent Progress in Nutrition, Journal Year: 2025, Volume and Issue: 05(02), P. 1 - 8

Published: April 8, 2025

In recent years, there has been an alarming increase in the incidence of inflammatory bowel disease (IBD), which includes both Crohn's (CD) and ulcerative colitis (UC), particularly Western countries. This chronic condition is intricately linked to composition health gut microbiota (GM) — a complex community microorganisms residing gastrointestinal (GI) tract. Despite extensive research, underlying pathogenesis IBD remains poorly understood, making it wide area investigation. review aims provide comprehensive exploration relationship between GM onset progression IBD. A key focus nucleotide-binding oligomerization domain-containing protein 2 (NOD2) pathway, plays crucial role immune response bacteria may influence susceptibility Through current literature, attempt was made understand how microbiome imbalance – dysbiosis can trigger processes associated with Moreover, this highlights vitamin D (VitD), fat-soluble that often deficient individuals affected by Research suggests VitD deficiency impair system disrupt health, contributing severity. Additionally, growing body evidence indicates metabolism involved NOD2 regulation. supplementation could potentially act as therapeutic strategy for managing IBD, alleviating symptoms enhancing overall health. study improve our understanding connection bacteria, system, nutrition, ultimately paving way more effective prevention treatment strategies

Language: Английский

Small intestine changes, large intestine problems DOI

Deepanshu Singla,

Annkatrin Rose,

Wenhan Zhu

et al.

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Evaluating the Efficacy of Secondary Metabolites in Antibiotic-Induced Dysbiosis: A Narrative Review of Preclinical Studies DOI Creative Commons
Corina Andrei, Anca Zanfirescu,

Victor-Pierre Ormeneanu

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 138 - 138

Published: Feb. 1, 2025

Background/Objectives: Drug-induced dysbiosis, particularly from antibiotics, has emerged as a significant contributor to chronic diseases by disrupting gut microbiota composition and function. Plant-derived secondary metabolites, such polysaccharides, polyphenols, alkaloids, saponins, show potential in mitigating antibiotic-induced dysbiosis. This review aims consolidate evidence preclinical studies on the therapeutic effects of metabolites restoring microbial balance, emphasizing their mechanisms efficacy. Methods: A narrative was conducted using PubMed, Scopus, Web Science. Studies were selected based specific inclusion criteria, focusing animal models treated with for The search terms included “gut microbiota”, “antibiotics”, “secondary metabolites”. Data extraction focused alterations, metabolite-specific effects, action. Relevant findings systematically analyzed summarized. Results: Secondary demonstrated diverse impact dysbiosis modulating composition, reducing inflammation, supporting host biological markers. Polysaccharides polyphenols restored Firmicutes/Bacteroidetes ratio, increased beneficial taxa Lactobacillus Bifidobacterium, suppressed pathogenic bacteria like Escherichia-Shigella. Metabolites triterpenoid saponins enhanced barrier integrity upregulating tight junction proteins, while alkaloids reduced inflammation proinflammatory cytokines (e.g., TNF-α, IL-1β). These also improved short-chain fatty acid production, which is crucial systemic health. While primary focus, other drug classes PPIs, metformin) require further investigation. Conclusions: promise managing improving Future research should explore applicability types drug-induced validate human enhance clinical relevance.

Language: Английский

Citations

0
Impact of nafcillin and diosmin on the attachment, invasion, and stress survival of Salmonella Typhimurium DOI Creative Commons
Negar Narimisa, Narjess Bostanghadiri, Amin Khoshbayan

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 21, 2025

Salmonella Typhimurium is an invasive intracellular pathogen that employs various factors for its survival within host cells. To mitigate S. survival, it crucial to identify influence bacterial and develop drugs inhibit these factors. In this study, we investigated the effects of nafcillin diosmin, both which have been identified as inhibitors Lon protease, on under stress conditions. Additionally, examined expression genes associated with type II toxin-antitoxin system enhance our understanding impact systems bacterium's survival. Our findings indicate while diosmin did not affect attachment, they significantly reduced particularly in Hep2 cells after 16 h. These were also effective decreasing oxidative acidic Furthermore, gene analysis revealed although there variations TA across different cell lines, relEB emerged most among those studied, exhibiting highest increase expression. This study highlights efficacy reducing well suggest potential new strategies developing therapies aimed at preventing infections.

Language: Английский

Citations

0
The Crucial Role of Vitamin D in Regulating Gut Microbiota in Inflammatory Bowel Disease DOI
Alessia Bartolacci, Fabrizio Stocchi, Vilberto Stocchi

et al.

Recent Progress in Nutrition, Journal Year: 2025, Volume and Issue: 05(02), P. 1 - 8

Published: April 8, 2025

In recent years, there has been an alarming increase in the incidence of inflammatory bowel disease (IBD), which includes both Crohn's (CD) and ulcerative colitis (UC), particularly Western countries. This chronic condition is intricately linked to composition health gut microbiota (GM) — a complex community microorganisms residing gastrointestinal (GI) tract. Despite extensive research, underlying pathogenesis IBD remains poorly understood, making it wide area investigation. review aims provide comprehensive exploration relationship between GM onset progression IBD. A key focus nucleotide-binding oligomerization domain-containing protein 2 (NOD2) pathway, plays crucial role immune response bacteria may influence susceptibility Through current literature, attempt was made understand how microbiome imbalance – dysbiosis can trigger processes associated with Moreover, this highlights vitamin D (VitD), fat-soluble that often deficient individuals affected by Research suggests VitD deficiency impair system disrupt health, contributing severity. Additionally, growing body evidence indicates metabolism involved NOD2 regulation. supplementation could potentially act as therapeutic strategy for managing IBD, alleviating symptoms enhancing overall health. study improve our understanding connection bacteria, system, nutrition, ultimately paving way more effective prevention treatment strategies

Language: Английский

Citations

0