Impact of Microbiota Diversity on Inflammatory Bowel Disease DOI Creative Commons
Ashwag Jaman Al-zahrani,

Basma M. Al-Hebshi,

Zolfekar A. Yahia

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 710 - 710

Published: March 21, 2025

Inflammatory bowel disease (IBD) is a chronic condition that includes two main types, Crohn’s (CD) and ulcerative colitis (UC), involving inflammation of the gastrointestinal (GI) tract. The exact cause IBD unknown but could be combination genetic, environmental, immune system factors. This study investigated impact on microbiota diversity by evaluating differences in microbial composition control group (A) healthy individuals (B) patients. Sixty biopsies were collected from participants recruited hospitals Makkah, Saudi Arabia. Biopsy specimens taken during colonoscopy examination, bacterial identification was performed extracting ribosomal DNA sigmoid colon using DNeasy Blood & Tissue Kit. Metagenomics bioinformatics analyses then conducted to analyze compare groups. results showed varieties core microbiome species 3.81% greater patients than members group. Furthermore, between groups significantly variations within each Differences detected relative abundance Clostridium nexile, Ruminococcus gnavus, faecis, Escherichia coli. These indicate play role pathogenesis suggest can serve as biomarker for diagnosing monitoring its progression.

Language: Английский

Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy DOI Creative Commons

Chen Gu,

Gengyu Sha, Baoqing Zeng

et al.

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute tumor initiation, immune suppression, and inflammation, establishing the as key therapeutic target. Fecal transplantation (FMT) has emerged transformative approach restore balance, enhance responses, reshape microenvironment. This review explores mechanisms underlying FMT’s potential, evaluates advantages over other microbiota-based interventions, addresses challenges such donor selection, safety concerns, treatment standardization. Looking forward, integration FMT into personalized CRC therapies requires robust clinical trials identification predictive biomarkers optimize efficacy safety.

Language: Английский

Citations

0
Impact of Microbiota Diversity on Inflammatory Bowel Disease DOI Creative Commons
Ashwag Jaman Al-zahrani,

Basma M. Al-Hebshi,

Zolfekar A. Yahia

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 710 - 710

Published: March 21, 2025

Inflammatory bowel disease (IBD) is a chronic condition that includes two main types, Crohn’s (CD) and ulcerative colitis (UC), involving inflammation of the gastrointestinal (GI) tract. The exact cause IBD unknown but could be combination genetic, environmental, immune system factors. This study investigated impact on microbiota diversity by evaluating differences in microbial composition control group (A) healthy individuals (B) patients. Sixty biopsies were collected from participants recruited hospitals Makkah, Saudi Arabia. Biopsy specimens taken during colonoscopy examination, bacterial identification was performed extracting ribosomal DNA sigmoid colon using DNeasy Blood & Tissue Kit. Metagenomics bioinformatics analyses then conducted to analyze compare groups. results showed varieties core microbiome species 3.81% greater patients than members group. Furthermore, between groups significantly variations within each Differences detected relative abundance Clostridium nexile, Ruminococcus gnavus, faecis, Escherichia coli. These indicate play role pathogenesis suggest can serve as biomarker for diagnosing monitoring its progression.

Language: Английский

Citations

0