Seleno-chitooligosaccharide-induced modulation of intestinal barrier function: Role of inflammatory cytokines, tight junction proteins, and gut microbiota in mice

Journal of Applied Biomedicine, Journal Year: 2025, Volume and Issue: 23(1), P. 45 - 55

Published: March 27, 2025

This study aimed to explore the function of Seleno-chitooligosaccharide (SOA) on intestinal barrier through regulation inflammatory cytokines, tight junction protein, and gut microbiota in mice. The results ELISA assay demonstrated that SOA significantly increased levels IL-2, IL-10, IFN-γ serum ileum. Meanwhile, IL-4 ileum (p < 0.05). In addition, Diamine Oxidase (DAO) concentration was decreased by treatments administration upregulated expression ZO-1 Occludin By 16S rDNA sequencing, reduced ratio Bacillota/Bacteroidota observed treated Within phylum Bacteroidota, relative abundance Deferribacterota, uncultured Bacteroidales bacterium, Bacteroides. Bacillota, Erysipelatoclostridium Lachnoclostridium, Ruminococcaceae UCG-010 were with supplement. summary, has potential modulate prevent diseases.

Language: Английский

Chitooligosaccharide enhances immune response and resistance of oyster Crassostrea gigas against Vibrio splendidus

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110347 - 110347

Published: April 1, 2025

Language: Английский