Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding DOI Creative Commons

Yingjuan He,

Gaomei Zhao,

Xue Ouyang

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 9, 2025

Ionizing radiation-induced intestinal injury (IRIII) is a catastrophic disease lack of sufficient medical countermeasures currently. Regulation the gut microbiota through dietary adjustments potential strategy to mitigate IRIII. Time-restricted feeding (TRF) an emerging behavioral nutrition intervention with pleiotropic health benefits. Whether this pattern influences pathogenesis IRIII remains vague. We evaluated impact TRF on radiosensitivity in study and discovered that only daytime (DTRF), not nighttime TRF, could ameliorate damage mice received high dose IR. Faecal metagenomic metabolomic studies revealed creatine level was increased by approximate 9 times DTRF, which Bifidobacterium pseudolongum enrichment contribute. Further investigations showed activate energy sensor AMP-activated protein kinase irradiated enterocytes induce phosphorylation acetyl-CoA carboxylase, resulting reduced production polyunsaturated fatty acids ferroptosis after The administration mitigated bacteremia proinflammatory responses. Blockade import compromised inhibition mitigation DTRF Our demonstrates radioprotective mode can reshape increase creatine, suppress IR-induced ferroptosis, thereby providing effective for prevention.

Language: Английский

Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding DOI Creative Commons

Yingjuan He,

Gaomei Zhao,

Xue Ouyang

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 9, 2025

Ionizing radiation-induced intestinal injury (IRIII) is a catastrophic disease lack of sufficient medical countermeasures currently. Regulation the gut microbiota through dietary adjustments potential strategy to mitigate IRIII. Time-restricted feeding (TRF) an emerging behavioral nutrition intervention with pleiotropic health benefits. Whether this pattern influences pathogenesis IRIII remains vague. We evaluated impact TRF on radiosensitivity in study and discovered that only daytime (DTRF), not nighttime TRF, could ameliorate damage mice received high dose IR. Faecal metagenomic metabolomic studies revealed creatine level was increased by approximate 9 times DTRF, which Bifidobacterium pseudolongum enrichment contribute. Further investigations showed activate energy sensor AMP-activated protein kinase irradiated enterocytes induce phosphorylation acetyl-CoA carboxylase, resulting reduced production polyunsaturated fatty acids ferroptosis after The administration mitigated bacteremia proinflammatory responses. Blockade import compromised inhibition mitigation DTRF Our demonstrates radioprotective mode can reshape increase creatine, suppress IR-induced ferroptosis, thereby providing effective for prevention.

Language: Английский

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