Current Radiopharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 30 - 37
Published: Oct. 25, 2023
Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (
Language: Английский
Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 93 - 109
Published: March 13, 2024
Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that highly upregulated GSCs compared normal, differentiated counterparts. Inhibition expression by shRNA significantly reduced GSC growth both vitro vivo experiments. On other hand, integrated transcriptomics analyses datasets revealed correlated cell cycle-related genes. Clinical data analysis elevated high-grade gliomas, patients with high levels have poorer overall survival outcomes. The findings suggest prognostic biomarker possible target developing novel therapeutic strategies against GBM.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 17, 2024
Abstract Glioblastoma is a deadly tumor which possesses glioblastoma stem cell populations involved in temozolomide resistance. To gain insight into the mechanisms of self-renewing and therapy-resistant cancer cells, subcellular proteomics was utilized to identify proteins whose expression enriched U251-derived stem-like cells. The RNA binding protein KHDRBS3 successfully identified as gene up-regulated population compared with its differentiated derivatives. Depletion by silencing led decrease proliferation, neurosphere formation, migration, genes stemness. Importantly, sensitivity can be induced knockdown. Collectively, our results highlight novel factor associated self-renewal cells As consequence, targeting may help eradicate
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123132 - 123132
Published: Oct. 1, 2024
Language: Английский
Citations
0
Cancer Genomics & Proteomics, Journal Year: 2024, Volume and Issue: 21(6), P. 608 - 621
Published: Oct. 28, 2024
Background/Aim: Glioma, the most common type of primary brain tumor, is characterized by high malignancy, recurrence, and mortality. Long non-coding RNA (lncRNA) H19 a potential biomarker for glioma diagnosis treatment due to its overexpression in human tissues involvement cell division metastasis regulation. This study aimed identify therapeutic targets involved development analyzing gene expression profiles regulated H19. Materials Methods: To elucidate role A172 U87MG lines, counting, colony formation, wound healing assays were conducted. RNA-seq data analysis bioinformatics analyses performed reveal molecular interactions Results: Cell-based experiments showed that elevated levels related cancer survival, proliferation, migration. Bioinformatics identified 2,084 differentially expressed genes (DEGs) influenced which are progression. Specifically, ANXA5, CLEC18B, RAB42, CXCL8, OASL, USP18, CDCP1 positively correlated with expression, while CSDC2 FOXO4 negatively correlated. These DEGs predicted function as oncogenes or tumor suppressors gliomas, association Conclusion: findings highlight associated diagnostic emphasizing their clinical significance patient survival.
Language: Английский
Citations
0
Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 536 - 550
Published: Nov. 1, 2024
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignant neoplasm, and up to now, the role of long non-coding RNA (lncRNA) AP001885.4 in cancer, including ESCC, absolutely unclear. The GEPIA database was applied identify differentially expressed prognosis-associated genes esophageal cancer (ESCA). CCK-8, colony formation, Western blot, qRT-PCR methods were harnessed investigate mechanism carcinogenesis. By analyzing TCGA data database, two lncRNAs selected. overexpressed positively associated with unfavorable outcome ESCC patients, LINC001786 under-expressed negatively linked poor prognosis. Knockdown suppressed proliferation formation cells. Importantly, silence downregulated c-myc. Mechanically, knockdown reduced METTL3 expression m6A modification c-myc mRNA, regulated Furthermore, diminished histone lactylation NF-κB (p65) expression, protein inhibitors (2-DG, 2-deoxy-D-glucose oxamate) inhibitor (JSH-23) also lessened expression. Consequently, our findings suggested that promoted cells by lactylation- (p65)-dependent transcription activation METTL3-mediated mRNA stability
Language: Английский
Citations
0
Cancer Genomics & Proteomics, Journal Year: 2024, Volume and Issue: 22(1), P. 70 - 80
Published: Dec. 27, 2024
Background/Aim: Glioblastoma is the most malignant brain tumor, and despite advances in treatment, survival rates are still dismal. Therefore, a comprehensive understanding of underlying molecular mechanisms glioblastoma needed. This study suggests potential therapeutic targets that may provide new insights. Materials Methods: To identify hub genes glioblastoma, three datasets were selected from GEO database. After screening DEGs using GEO2R, GO KEGG analyses performed DAVID. The PPI network was visualized Cytoscape 7 extracted. prognostic investigated Gliovis GEPIA2 databases. Results: In total, 176 up-regulated 263 down-regulated identified. From network, identified including CAMK2A, DLG4, SNAP25, SYT1, MYC, FN1, VEGFA. Out identified, FN1 VEGFA have been associated with poor prognosis based on analysis. Conclusion: high levels expression both promising for therapy. Bioinformatics analysis revealed putative might reveal glioblastoma.
Language: Английский
Citations
0
Biologics, Journal Year: 2023, Volume and Issue: Volume 17, P. 41 - 42
Published: March 1, 2023
Letter for the article The Cancer Driver Genes IDH1 and IDH2 CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Metabolism Tumour Associated Macrophage Recruitment Microenvironment
Language: Английский
Citations
0
Current Radiopharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 30 - 37
Published: Oct. 25, 2023
Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (
Language: Английский
Citations
0