The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 2, 2025

Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.

Language: Английский

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Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

A growing number of in vitro and vivo studies suggest the application probiotics as a natural approach to maintaining oral health. This double-blind, randomized controlled trial aimed evaluate efficacy Levilactobacillus brevis CD2 (CNCM I-5566), multifunctional probiotic frequently used medicine, preserving or improving several recognized health indicators. Thirty consenting healthy adults were receive four lozenges per day L. (n = 15) placebo over weeks. Clinical parameters (full-mouth bleeding on probing (BoP) plaque index (PI) scores) recorded. Unstimulated saliva was collected measure salivation rate, pH, buffer capacity. Salivary biomarkers analyzed, including glucose, D-lactate, secretory immunoglobulins (sIgA). salivary assessed at baseline, after weeks intervention, two post-intervention. Wilcoxon rank-sum test robust regression analysis for statistical comparisons. The possible mediating effect PI BoP changes assessed. After weeks, group showed significant improvements compared baseline placebo. had higher rate than treatment washout. While pH not significant, buffering capacity increased glucose D-lactate levels lower post-treatment sIgA values remained stable washout group. No adverse effects reported. with significantly improved clinical parameters, supporting its ClinicalTrials.gov , NCT06457724; Registered 7 June 2024 - Retrospectively registered; https://clinicaltrials.gov/study/NCT06457724?viewType=Table&page=452&rank=4512#study-overview .

Language: Английский

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Improving the glass ionomer restoration by Incorporating strontium NPs coated with AuNPs manufactured by laser ablation in liquid

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 164, P. 112411 - 112411

Published: April 20, 2024

Language: Английский

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Competitive dynamics and balance between Streptococcus mutans and commensal streptococci in oral microecology

Critical Reviews in Microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Aug. 12, 2024

Dental caries, as a biofilm-related disease, is closely linked to dysbiosis in microbial ecology within dental biofilms. Beyond its impact on oral health, bacteria the cavity pose systemic health risks by potentially entering bloodstream, thereby increasing susceptibility bacterial endocarditis, among other related diseases.

Language: Английский

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The oral microbiota and periodontal health in orthodontic patients

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from parents by 4 years‐of‐age. plays an important role in overall health/symbiosis individual. Deviations state symbiosis leads to dysbiosis increased risk pathogenicity. can occur not only daily life activities but also orthodontic interventions. Orthodontic appliances are formed a variety biomaterials. Once inserted, they serve as breeding ground for microbial attachment, new surface areas crevices material physicochemical interactions different than symbiotic state. Individuals undergoing treatment show, compared with untreated people, qualitative quantitative differences activity microbiota, induced retention supra‐ subgingival plaque throughout period. These changes at root main undesirable effects, such gingivitis, white spot lesions (WSL), more severe caries lesions. Notably, profile weeks intervention might be valuable indicator predict identify higher‐risk individuals respect periodontal health otherwise healthy population. Antimicrobial coatings have been used dissuade microbes adhering biomaterial; however, disrupt host several bacterial strains become resistant. Smart biomaterials that reduce antimicrobial load preventing adhesion shown promising results, their complexity has kept many solutions reaching clinic. 3D printing technology provides opportunities complex chemical syntheses performed uniformly, reducing cost producing smart giving hope may reach clinic near future. purpose this review is emphasize importance during therapy use innovative technologies better maintain its balance surgical procedures.

Language: Английский

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Bacterial dynamics in the progression of caries to apical periodontitis in primary teeth of children with severe early childhood caries

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 11, 2024

Early childhood caries (ECC) are a prevalent chronic disease in young children. However, there has been limited research on the microbiota different tissue levels of same tooth children with ECC. This study aimed to investigate dynamic changes bacterial diversity during progression Severe Childhood Caries (S-ECC) within tooth, from surface root canal, by collecting samples areas affected tooth.

Language: Английский

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The host genotype actively shapes its microbiome across generations

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected 2-cell stage embryos from representative wildtypes, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. graphical abstract

Language: Английский

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Results of a Pilot Trial Assessing the Effects of Proper Oral Hygiene and a Probiotic Dietary Supplement on Oral Health in Volunteers with Oral Malodor

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1821 - 1821

Published: Sept. 3, 2024

Persistent malodor affects many people worldwide and is usually associated with poor dental hygiene. This pilot trial aimed to determine whether proper hygiene (DH) a probiotic dietary supplement support oral health in volunteers persistent malodor. Volunteers (

Language: Английский

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The role of Lactobacillus plantarum in oral health: a review of current studies

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 22, 2024

Oral non-communicable diseases, particularly dental caries and periodontal disease, impose a significant global health burden. The underlying microbial dysbiosis is prominent factor, driving interest in strategies that promote balanced oral microbiome.

Language: Английский

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The host genotype actively shapes its microbiome across generations in laboratory mice

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 5, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected two-cell stage embryos from representative wild types, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. Graphical

Language: Английский

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