Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions DOI Creative Commons
Natalia E. Fares‐Otero, Norma Verdolini, Helena Melero

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 16, 2024

Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs FEP on CT remain understudied. One-hundred sixteen individuals with (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) 98 healthy controls (HCs) 24.4 6.2 43% females) reported the presence/absence CA <17 years using an adapted version Childhood Experience Care Abuse (CECA.Q) Retrospective Bullying Questionnaire (RBQ) underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used assess associations brain maps effects. General linear models (GLMs) performed interaction CT. Eighty-three 83 HCs exposure at least one CA. similar those found participants exposed separation from parents, bullying, parental discord, household poverty, sexual abuse (r 0.50 0.25). Exposure neglect (β -0.24, 95% CI [-0.37 -0.12], p 0.016) overall maltreatment -0.13, [-0.20 -0.06], 0.043) associated thinning right medial orbitofrontal region. Cortical are observed context socio-environmental adversity. Neglect may contribute reductions FEP. Our findings provide new insights into specific neurobiological early psychosis.

Language: Английский

Childhood maltreatment: A call for a standardised definition and applied framework DOI
Natalia E. Fares‐Otero, Soraya Seedat

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 24 - 26

Published: July 17, 2024

Language: Английский

Citations

7
Social cognition in maltreated individuals: Do type and timing of maltreatment matter? DOI
Natalia E. Fares‐Otero, Inga Schalinski

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 81, P. 38 - 40

Published: Feb. 6, 2024

Language: Английский

Citations

4
Childhood maltreatment influences coping in youths with major depression and bipolar depression through resilience and impulsivity DOI Creative Commons
Jiawei Zhou, Zheng Zhang, Sihong Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Language: Английский

Citations

0
Social support and (complex) posttraumatic stress symptom severity: does gender matter? DOI Creative Commons
Natalia E. Fares‐Otero, Tamsin Sharp,

Stefanie R. Balle

et al.

European journal of psychotraumatology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 15, 2024

Perceived social support is an established predictor of post-traumatic stress disorder (PTSD) after exposure to a traumatic event. Gender important factor that could differentiate responses support, yet this has been little explored. Symptoms complex PTSD are also common following trauma but have under-researched in context. Large scale studies with culturally diverse samples particularly lacking.

Language: Английский

Citations

3
Immune dysregulation in psychiatric disorders with and without exposure to childhood maltreatment: A transdiagnostic stratified meta-analysis DOI Creative Commons
Minne Van Den Noortgate, Manuel Morrens, Marianne Foiselle

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Childhood maltreatment (CM), i.e. physical, psychological, or sexual abuse and neglect, affects approximately one third of the general population is an important risk factor for all major psychiatric disorders. Exposure to CM also has a profound impact on immune function, with both factors independently implicated in development prognosis different mental This study aims 1) assess differences markers among adults diagnosed disorders without history 2) explore role as mediating abnormalities patients compared non-psychiatric controls. A PRISMA-compliant systematic search PubMed, Web Science Embase databases was performed until October 24th, 2024 original studies that assessed trauma-stratified adult (PROSPERO ID CRD42021273059). We modelled random-effects meta-analyses compare levels pro-inflammatory (PIM), anti-inflammatory (AIM) cellular (CIM) between traumatized (CM + ) non-traumatized (CM-) individuals, investigated exposure Secondary analyses were diagnostic subgroups individual markers. Study quality Newcastle Ottawa Scale. included data from 53 n = 12,141 mood (MD), schizophrenia spectrum (SSD), substance use (SUD), eating (ED) anxiety (AD). uncovered consistent transdiagnostic blood-based molecules (OR 1.186; 95 % CI 1.030-1.365, p 0.018) effect not observed controls same studies. did find evidence specific trauma-induced composite scores separate subgroups, except PIM SUD 2.324, 1.043-5.182, 0.039). Interleukin 6 (IL-6) identified significant mediator diagnosis adulthood 1.609; 1.100-2.353, 0.014), while increases C-reactive protein (CRP) 10 (IL-10) appear be trauma-specific. Our findings confirm increased molecular patients. IL-6 emerged crucial mediator, suggesting leads alterations predisposing individuals conditions. meta-analysis highlights potentially mechanism contributing vulnerability towards illness later life.

Language: Английский

Citations

0
Childhood Maltreatment and Cognitive Functioning in Bipolar Disorder: A Systematic Review and Meta‐Analysis DOI Creative Commons
Natalia E. Fares‐Otero,

Anaid Pérez‐Ramos,

R. López-Escribano

et al.

Acta Psychiatrica Scandinavica, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

ABSTRACT Aims Characterising the association between childhood maltreatment (CM) and cognitive functioning in bipolar disorder (BD) is crucial for improving understanding of how early environmental risk factors impact presentation disorder. We conducted a systematic review meta‐analysis to estimate associations overall subtypes CM, global cognition/IQ, five domains BD (attention/processing speed, verbal memory/learning, working memory, executive functions/verbal fluency, social cognition), explore moderators/mediators these associations. Methods A search was performed on 24 June 2024 identify published peer‐reviewed articles six databases (PROSPERO‐CRD42023468641). Results From 780 identified records, 20 studies were included, comprising 2457 individuals with (M ± SD, age years = 39.5 9.7; 41.3% males; type I 81.2%); 152 effect sizes pooled random‐effect meta‐analyses. Overall CM negatively associated attention/processing memory/learning ( r −0.14 −0.18, p 0.002 < 0.001). Sexual/physical abuse physical neglect fluency −0.07 0.037 Emotional memory −0.12, 0.002). unrelated functions. (overall/subtypes) cognition. Meta‐regressions did not any consistent moderators. Narrative synthesis possible moderators/mediators. Associations small magnitude, limited number assessing functions are available. Conclusion exposure worse performance people BD, an observed across multiple types domains. Besides trauma‐informed interventions, those require assessment therapies rehabilitate functioning.

Language: Английский

Citations

0
A meta-analysis of genome-wide studies of resilience in the German population DOI Creative Commons
Marisol Herrera-Rivero, Linda Garvert, Katrin Horn

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract Resilience is the capacity to adapt stressful life events. As such, this trait associated with physical and mental functions conditions. Here, we aimed identify genetic factors contributing shape resilience. We performed variant- gene-based meta-analyses of genome-wide association studies from six German cohorts (N = 15822) using 11-item version Scale (RS-11) as outcome measure. Variant- gene-level results were combined explore biological context network analysis. In addition, conducted tests correlation between RS-11 polygenic scores (PGSs) for 12 personality health traits in one these (PROCAM-2, N 3879). The variant-based analysis found no signals resilience at level (p < 5 × 10 −8 ), but suggested five genomic loci 1 −5 ). identified three genes ( ROBO1 , CIB3 LYPD4 ) 2.48 −6 32 potential candidates −4 Network revealed enrichment pathways related neuronal proliferation differentiation, synaptic organization, immune responses vascular homeostasis. also significant correlations (FDR 0.05) PGSs neuroticism general happiness. Overall, our observations suggest low heritability Large, international efforts will be required uncover that contribute Nevertheless, largest investigation genetics population date, study already offers valuable insights into biology potentially underlying resilience’s relationship other health.

Language: Английский

Citations

1
The Relationship Between Self-Compassion and Resilience in the General Population: Protocol for a Systematic Review and Meta-Analysis DOI Creative Commons
Xinyi Li, Melina Aikaterini Malli, Theodore D. Cosco

et al.

JMIR Research Protocols, Journal Year: 2024, Volume and Issue: 13, P. e60154 - e60154

Published: Dec. 5, 2024

Background Resilience can protect individuals from the negative impact of adversity, facilitating a swift recovery. The exploration protective factors contributing to resilience has been central focus research. Self-compassion, positive psychological construct that involves treating oneself with kindness, holds potential bolster resilience. Although several studies have indicated an association between self-compassion and resilience, there is lack systematic reviews meta-analyses examining this relationship moderators mechanisms. Objective This study aimed systematically review literature on in general population, perform meta-analysis quantify effect size their association, explore (eg, age, gender, culture, health status) mediators. Methods We will search Web Science, PsycINFO, MEDLINE, Scopus, CINAHL, CNKI databases for peer-reviewed (including observational experimental studies) examined no language restrictions. There are restrictions regarding participants’ or status. Qualitative studies, conference abstracts, articles, case reports, editorials be excluded. Two reviewers (XL JH) independently screen literature, extract data, assess quality eligible studies. If possible, pooled meta-analyzed using random-effect model. Meta-regression subgroup analysis conducted examine moderating roles status, other moderators. characteristics main findings summarized tables narrative descriptions. Results meta-analysis, meta-regression, presented quantitatively. registered our protocol PROSPERO, search, initiated screening April 2024. expect start data October 2024 finalize by March 2025. Conclusions provide evidence role under adversity. Our investigation into highlight contexts groups where benefits maximized. expected valuable insights care professionals stakeholders, informing development interventions at enhancing fostering self-compassion. Trial Registration PROSPERO CRD42024534390; https://tinyurl.com/3j3rmcja International Registered Report Identifier (IRRID) PRR1-10.2196/60154

Language: Английский

Citations

0
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions DOI Creative Commons
Natalia E. Fares‐Otero, Norma Verdolini, Helena Melero

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 16, 2024

Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs FEP on CT remain understudied. One-hundred sixteen individuals with (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) 98 healthy controls (HCs) 24.4 6.2 43% females) reported the presence/absence CA <17 years using an adapted version Childhood Experience Care Abuse (CECA.Q) Retrospective Bullying Questionnaire (RBQ) underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used assess associations brain maps effects. General linear models (GLMs) performed interaction CT. Eighty-three 83 HCs exposure at least one CA. similar those found participants exposed separation from parents, bullying, parental discord, household poverty, sexual abuse (r 0.50 0.25). Exposure neglect (β -0.24, 95% CI [-0.37 -0.12], p 0.016) overall maltreatment -0.13, [-0.20 -0.06], 0.043) associated thinning right medial orbitofrontal region. Cortical are observed context socio-environmental adversity. Neglect may contribute reductions FEP. Our findings provide new insights into specific neurobiological early psychosis.

Language: Английский

Citations

0