Development of Etoricoxib loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: Optimization, ex-vivo permeation, histopathology and in-vivo anti-inflammatory study. DOI
Dibyalochan Mohanty,

N. G. Divya,

Ameeduzzafar Zafar

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 7, 2025

Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into carbopol-chitosan evaluated in-vitro, ex-vivo, in-vivo activity. displayed nanosize of particles with distribution high entrapment efficiency ETB. FTIR DSC studies showed that ETB encapsulated in MSNPs. successfully integrated the carbopol chitosan gel, which exhibited excellent viscosity spreadability. significantly higher more sustained release compared pure gel. Optimized considerably effect significant reduction IL-1β TNF-α levels histopathological examination confirmed did not exhibit any toxicity on skin. Based findings, results suggest MSNPs potential carrier enhancing efficacy through topical delivery, although further are needed fully confirm its effectiveness.

Language: Английский

Development of Etoricoxib loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: Optimization, ex-vivo permeation, histopathology and in-vivo anti-inflammatory study. DOI
Dibyalochan Mohanty,

N. G. Divya,

Ameeduzzafar Zafar

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 7, 2025

Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into carbopol-chitosan evaluated in-vitro, ex-vivo, in-vivo activity. displayed nanosize of particles with distribution high entrapment efficiency ETB. FTIR DSC studies showed that ETB encapsulated in MSNPs. successfully integrated the carbopol chitosan gel, which exhibited excellent viscosity spreadability. significantly higher more sustained release compared pure gel. Optimized considerably effect significant reduction IL-1β TNF-α levels histopathological examination confirmed did not exhibit any toxicity on skin. Based findings, results suggest MSNPs potential carrier enhancing efficacy through topical delivery, although further are needed fully confirm its effectiveness.

Language: Английский

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