Prostaglandin E2 may clinically alleviate dry eye disease by inducing Th17 cell differentiation DOI
Jingyao Chen,

Yu Gong,

Xiaoyu Sun

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(2)

Published: Feb. 1, 2024

Dry eye (DE) is a multifactorial ocular surface disease characterised by an imbalance in tear homeostasis. The pathogenesis of DE complex and related to environmental, immunological (e.g., T helper 17 cells) other factors. However, the remains unclear, thereby affecting its clinical treatment. This study aimed explore mechanism through which prostaglandin E2 (PGE2) affects inflammation regulating Th17. mouse model was established subcutaneous injection scopolamine hydrobromide. secretion test break-up time (BUT) method were used detect film BUT, respectively. Enzyme-linked immunosorbent assay (ELISA) concentrations PGE2, interleukin (IL)-17, IL-6 tumour necrosis factor (TNF-α) fluid those PGE2 IL-17 serum. RT-qPCR western blotting mRNA protein expression levels retinoid-related orphan receptor-γt (RORγt). highly expressed model. key Th17 transcription RORγt increased tissues mice. Moreover, promoted secretion, reduced concentration tears cell proportion DE, whereas receptor inhibitor AH6809 reversed effects on draining lymph node (DLN) cells. Taken together, findings indicate that could induce DE-related symptoms promoting differentiation.

Language: Английский

Unveiling the hidden effects of hypoxia: Pituitary damage and hormonal imbalance in fat greenling (Hexagrammos otakii) DOI Creative Commons
Wei Wang, Yu Zhan, Dongxu Gao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172381 - 172381

Published: April 10, 2024

In fisheries, hypoxia stress is one of the most common environmental stresses that often lead to death large numbers fish and cause significant economic losses. The pituitary, an important endocrine gland, lies below hypothalamus region brain. It plays a crucial part in controlling vital physiological functions fish, such as growth, reproduction, responses stress. However, detailed mechanisms how affects these processes via pituitary remain largely unknown.

Language: Английский

Citations

3
Recommendations for nutritional supplements for dry eye disease: current advances DOI Creative Commons

Ying Cong,

Yibing Zhang,

Yutong Han

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact oral supplements, varying composition dosage, on symptoms DED. main components these supplements include fish oils (Omega-3 acids), vitamins, trace elements, phytochemical extracts. Beyond well-known nutrients, it necessary explore whether novel nutrients might contribute more management. This review provides comprehensive update therapeutic potential presents new perspectives combination treatment.

Language: Английский

Citations

2
Prostaglandin E2 may clinically alleviate dry eye disease by inducing Th17 cell differentiation DOI
Jingyao Chen,

Yu Gong,

Xiaoyu Sun

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(2)

Published: Feb. 1, 2024

Dry eye (DE) is a multifactorial ocular surface disease characterised by an imbalance in tear homeostasis. The pathogenesis of DE complex and related to environmental, immunological (e.g., T helper 17 cells) other factors. However, the remains unclear, thereby affecting its clinical treatment. This study aimed explore mechanism through which prostaglandin E2 (PGE2) affects inflammation regulating Th17. mouse model was established subcutaneous injection scopolamine hydrobromide. secretion test break-up time (BUT) method were used detect film BUT, respectively. Enzyme-linked immunosorbent assay (ELISA) concentrations PGE2, interleukin (IL)-17, IL-6 tumour necrosis factor (TNF-α) fluid those PGE2 IL-17 serum. RT-qPCR western blotting mRNA protein expression levels retinoid-related orphan receptor-γt (RORγt). highly expressed model. key Th17 transcription RORγt increased tissues mice. Moreover, promoted secretion, reduced concentration tears cell proportion DE, whereas receptor inhibitor AH6809 reversed effects on draining lymph node (DLN) cells. Taken together, findings indicate that could induce DE-related symptoms promoting differentiation.

Language: Английский

Citations

0