Clinical Study of Intelligent Tongue Diagnosis and Oral Microbiome for Classifying TCM Syndromes in MASLD DOI
Juncai Deng,

Shixuan Dai,

Shi Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Background This study aimed to analyze the tongue image features and oral microbial markers in different TCM syndromes related metabolic dysfunction-associated steatotic liver disease (MASLD). Methods involved 34 healthy volunteers 66 MASLD patients [36 with Dampness-Heat (DH) 30 Qi-Deficiency (QD) syndrome]. Oral microbiome analysis was conducted through 16S rRNA sequencing. Tongue feature extraction used Uncertainty Augmented Context Attention Network (UACANet), while syndrome classification performed using five machine learning methods based on microbiota. Results Significant differences color, coating, microbiota were noted between DH band QD patients. exhibited a red-crimson color greasy coating enriched Streptococcus Rothia tongue. In contrast, displayed pale higher abundances of Neisseria, Fusobacterium, Porphyromonas Haemophilus. Combining characteristics differentiated an AUC 0.939 accuracy 85%. Conclusion suggests that are metabolism, possess distinct biomarkers, supporting classification.

Language: Английский

Fusobacterium nucleatum modulates the Wnt/β-catenin pathway in colorectal cancer development DOI
Tanushree Mondal, Debasish Chattopadhyay, P. Mondal

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140196 - 140196

Published: Jan. 21, 2025

Language: Английский

Citations

2
Oral Fusobacterium nucleatum exacerbates ulcerative colitis via the oral-gut axis: mechanisms and therapeutic implications DOI Creative Commons
Zhili Zheng, Wenqin Jin, Weiwei Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium known for its association with periodontal disease and oral infections. It has been implicated in the development of gastrointestinal diseases such as inflammatory bowel colorectal cancer. Ulcerative colitis (UC), which characterized by chronic inflammation colon, a condition unknown etiology rising incidence rate, significantly affecting quality life patients. The increased intestinal permeability during UC may facilitate adherence or invasion F. into damaged barrier, leading to exacerbated inflammation. This article introduces concept oral-gut axis, reviewing existing literature analyze role pathogenesis exploring potential pathogenic mechanisms. also summarizes latest advances treating patients who have looks forward prospective therapeutic strategies translational prospects within axis. be key player UC, likely due invasiveness periods permeability. paper discusses innovative approaches prevention management nucleatum, paving way more effective treatment UC. review offers new insights complex relationship between microbiome diseases, enhancing our understanding their dynamic interactions. There paucity on approaches, indicating need further clinical research.

Language: Английский

Citations

0
Clinical Study of Intelligent Tongue Diagnosis and Oral Microbiome for Classifying TCM Syndromes in MASLD DOI
Juncai Deng,

Shixuan Dai,

Shi Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Background This study aimed to analyze the tongue image features and oral microbial markers in different TCM syndromes related metabolic dysfunction-associated steatotic liver disease (MASLD). Methods involved 34 healthy volunteers 66 MASLD patients [36 with Dampness-Heat (DH) 30 Qi-Deficiency (QD) syndrome]. Oral microbiome analysis was conducted through 16S rRNA sequencing. Tongue feature extraction used Uncertainty Augmented Context Attention Network (UACANet), while syndrome classification performed using five machine learning methods based on microbiota. Results Significant differences color, coating, microbiota were noted between DH band QD patients. exhibited a red-crimson color greasy coating enriched Streptococcus Rothia tongue. In contrast, displayed pale higher abundances of Neisseria, Fusobacterium, Porphyromonas Haemophilus. Combining characteristics differentiated an AUC 0.939 accuracy 85%. Conclusion suggests that are metabolism, possess distinct biomarkers, supporting classification.

Language: Английский

Citations

0