Neutrophils in colorectal cancer: mechanisms, prognostic value, and therapeutic implications

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Neutrophils, the most abundant myeloid cells in human peripheral blood, serve as first defense line against infection and are also significantly involved initiation progression of cancer. In colorectal cancer (CRC), neutrophils exhibit a dual function by promoting tumor events exerting antitumor activity, which is related to heterogeneity neutrophils. The neutrophil extracellular traps (NETs), gut microbiota, various within microenvironment (TME) shaping heterogeneous This article provides an updated overview complex functions underlying mechanisms CRC their pivotal role guiding prognosis assessment therapeutic strategies, aiming offer novel insights into neutrophil-associated treatment approaches for CRC.

Language: Английский

Neurogranin facilitates maintaining the immunosuppressive state of hepatocellular carcinoma by promoting TGF-β1 secretion

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143716 - 143716

Published: May 1, 2025

Language: Английский

Withametelin inhibits TGF-β induced Epithelial-to-Mesenchymal Transition and Programmed-Death Ligand-1 expression in vitro

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 15, 2024

Withanolides are a group of naturally occurring plant-based small molecules known for their wide range host cellular functions. The anticancer potential withanolides has been explored in varying cancer cell lines

Language: Английский