Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management DOI Creative Commons

Chengjie Zhao,

Ruoyan Lei,

Siyang Liu

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: June 19, 2024

Kounis syndrome is an acute coronary triggered by allergic mediators that induce vasoconstriction and thrombosis, leading to further myocardial damage anaphylactic shock. also a rare but severe adverse reaction the COVID-19 vaccine, phenomenon underscores importance of collecting analyzing similar cases improve treatment prognosis. Through comprehensive searches Web Science, Embase, PubMed databases, this study aimed gather detailed patient data on patients who developed after receiving vaccine investigate possible underlying mechanisms using currently available studies. A total 15 (8 females, 7 males) were found. We analyzed data, including demographics, vaccination details, time onset illness vaccination, clinical manifestations, outcomes, duration illness, relevant examination results. Analysis these combined with known allergy-related indicated that, regardless type, first dose was more likely cause than subsequent doses. Therefore, early diagnosis symptomatic are particularly crucial for managing severity preventing cardiac complications. Additionally, when unusual occurs within few hours it important closely monitor development cardiac-related symptoms prepare clinically potential syndrome.

Language: Английский

The relationship between vaccination and uveitis: A comprehensive review of immune response, risk assessment, and clinical implications DOI Creative Commons
Yihan Zhang, Tianyu Tao, Zhaohuai Li

et al.

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Uveitis, an intraocular inflammatory condition, can lead to significant visual impairment and is often associated with abnormal immune system activation. While vaccination stands as a pivotal defense against numerous infectious diseases, its safety effectiveness in individuals uveitis have come under heightened scrutiny. This concern arises from the potential impact of both disease itself immunosuppressive treatments on function. Several studies drawn connections between various vaccines onset uveitis, particularly hepatitis B, human papillomavirus, influenza vaccines. Furthermore, though exceedingly rare, instances following COVID‐19 been documented, adding another layer complexity. review delves into intricate relationship assesses risks for those afflicted, explores underlying mechanisms behind vaccine‐induced uveitis. Finally, it offers recommendations patients emphasizes imperative further investigation unravel complex dynamics ultimately informing clinical practice.

Language: Английский

Citations

1
Vogt-Koyanagi-Harada Syndrome Following COVID-19 mRNA Vaccination: Th2 to Th1 Transition-related Molecular Machinery DOI Creative Commons
Yasuaki Ikuno, Akihiko Yamaguchi, Toshifumi Takahashi

et al.

Acta Dermato Venereologica, Journal Year: 2024, Volume and Issue: 104, P. adv21502 - adv21502

Published: May 13, 2024

Abstract is missing (Short communication)

Language: Английский

Citations

2
Comprehensive insights into COVID-19 vaccine-associated multiple evanescent white dot syndrome (MEWDS): A systematic analysis of reported cases DOI Creative Commons
Yuqin Zeng,

DU Zhenzhen,

Chuhan Shao

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: May 16, 2024

Considering the widespread use of COVID-19 vaccines as a preventive measure against spread virus, it's necessary to direct attention adverse effects associated with in limited group populations. Multiple evanescent white dot syndrome (MEWDS) following vaccination is rare reaction vaccines. In this systematic review, we collected 19 articles 27 patients up November 1, 2023, summarizing basic information, clinical manifestations, examinations, treatments, and recoveries patients. The enrolled (6 males, 21 females) had median age 34.1 years (15-71 old) were mainly from 5 regions: Asia (8), Mediterranean region North America (7), Oceania (3) Brazil (1). Symptoms occurred post-first dose 9 patients, post-second 14 (1 symptoms after both), post-third both booster doses while details on 2 cases not disclosed. Treatments included tapered oral steroids (6), topical (3), prednisone antiviral drugs vitamins (1), valacyclovir acetazolamide 16 received no treatment. All experienced symptom improvement, nearly all ultimately recovered. Moreover, summarized possible hypotheses concerning mechanism vaccine-associated MEWDS. findings provide insights into aspects More should be given MEWDS, treatment provided experiencing substantial decline visual acuity improve their quality life.

Language: Английский

Citations

1
Kounis syndrome following COVID-19 vaccination: Clinical manifestations, mechanisms and management DOI Creative Commons

Chengjie Zhao,

Ruoyan Lei,

Siyang Liu

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: June 19, 2024

Kounis syndrome is an acute coronary triggered by allergic mediators that induce vasoconstriction and thrombosis, leading to further myocardial damage anaphylactic shock. also a rare but severe adverse reaction the COVID-19 vaccine, phenomenon underscores importance of collecting analyzing similar cases improve treatment prognosis. Through comprehensive searches Web Science, Embase, PubMed databases, this study aimed gather detailed patient data on patients who developed after receiving vaccine investigate possible underlying mechanisms using currently available studies. A total 15 (8 females, 7 males) were found. We analyzed data, including demographics, vaccination details, time onset illness vaccination, clinical manifestations, outcomes, duration illness, relevant examination results. Analysis these combined with known allergy-related indicated that, regardless type, first dose was more likely cause than subsequent doses. Therefore, early diagnosis symptomatic are particularly crucial for managing severity preventing cardiac complications. Additionally, when unusual occurs within few hours it important closely monitor development cardiac-related symptoms prepare clinically potential syndrome.

Language: Английский

Citations

0