RECENT INSIGHTS ON PATTERN RECOGNITION RECEPTORS AND THE INTERPLAY OF INNATE IMMUNE RESPONSES AGAINST WEST NILE VIRUS INFECTION DOI

Jatin Behari,

Kajal Yadav, Prashant Khare

et al.

Virology, Journal Year: 2024, Volume and Issue: 600, P. 110267 - 110267

Published: Oct. 18, 2024

Language: Английский

Harnessing Epigenetics: Innovative Approaches in Diagnosing and Combating Viral Acute Respiratory Infections DOI Creative Commons
Ankita Saha, Anirban Ganguly, Anoop Kumar

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 129 - 129

Published: Feb. 1, 2025

Acute respiratory infections (ARIs) caused by viruses such as SARS-CoV-2, influenza viruses, and syncytial virus (RSV), pose significant global health challenges, particularly for the elderly immunocompromised individuals. Substantial evidence indicates that acute viral can manipulate host's epigenome through mechanisms like DNA methylation histone modifications part of immune response. These epigenetic alterations persist beyond phase, influencing long-term immunity susceptibility to subsequent infections. Post-infection modulation host may help distinguish infected from uninfected individuals predict disease severity. Understanding these interactions is crucial developing effective treatments preventive strategies ARIs. This review highlights critical role following ARIs in regulating innate defense mechanisms. We discuss implications diagnosing, preventing, treating infections, contributing advancement precision medicine. Recent studies have identified specific changes, hypermethylation interferon-stimulated genes severe COVID-19 cases, which could serve biomarkers early detection progression. Additionally, therapies, including inhibitors methyltransferases deacetylases, show promise modulating response improving patient outcomes. Overall, this provides valuable insights into landscape ARIs, extending traditional genetic perspectives. are essential advancing diagnostic techniques innovative address growing threat emerging causing globally.

Language: Английский

Citations

1
CCL17 influences Borrelia burgdorferi infection in the heart DOI
Xiaotian Tang, Qian Yu, Yingjun Cui

et al.

The Journal of Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Lyme disease, caused by Borrelia burgdorferi, is transmitted to humans Ixodes ticks. CCL17 a potent chemokine that plays important roles in diverse illnesses, including autoimmune and infectious diseases. knockout mice, infected with B. had reduced pathogen load the heart compared control animals. Mice lacking also showed signs of immune alteration upon burgdorferi infection, serum levels proinflammatory cytokines less monocytes macrophages infiltration. interacts directly first demonstration this has an affinity for vector-borne pathogen.

Language: Английский

Citations

0
Antimicrobial Peptides Against Arboviruses: Mechanisms, Challenges, and Future Directions DOI
Iman Owliaee,

Mehran Khaledian,

Ali Shojaeian

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
RECENT INSIGHTS ON PATTERN RECOGNITION RECEPTORS AND THE INTERPLAY OF INNATE IMMUNE RESPONSES AGAINST WEST NILE VIRUS INFECTION DOI

Jatin Behari,

Kajal Yadav, Prashant Khare

et al.

Virology, Journal Year: 2024, Volume and Issue: 600, P. 110267 - 110267

Published: Oct. 18, 2024

Language: Английский

Citations

1