EClinicalMedicine, Journal Year: 2025, Volume and Issue: 79, P. 103016 - 103016
Published: Jan. 1, 2025
Vaccine co-administration can increase vaccination coverage. We assessed the safety, reactogenicity, and immunogenicity of concomitant administration Ad26.COV2.S COVID-19 vaccine with seasonal influenza vaccines. This non-inferiority, Phase 3, randomised, double-blind study enrolled 859 healthy adults was conducted between 02 November 2021 28 2022. Participants aged ≥18-64 years were randomised to receive a quadrivalent standard dose (SD) (Afluria Quadrivalent, Seqirus) concomitantly (Coad_SD) or placebo (0.9% NaCl; Control_SD) on Day 1 29. ≥65-years Coad_SD Control_SD groups, Coad_HD Control_HD groups that received HD (high-dose) (Fluzone High-Dose Sanofi Pasteur Inc) in same schedules. The primary outcomes haemagglutinin inhibition titres against four strains at 29, SARS-CoV-2 Spike-specific antibodies 29 group 57 Control-SD group, non-inferiority margin (Control-SD group/Coad_SD group) 1.5. Reactogenicity safety all participants (NCT05091307). Non-inferiority criteria for SD met (ratio 1.11, 95% CI 0.97-1.26) (A/H3N2 1.23, 1.05-1.45; B/Victoria 0.99, 0.84-1.19; B/Yamagata, 1.03, 0.88-1.21) except A/H1N1 (1.28, 1.09-1.53) which upper limit >1.5. Concomitant induced robust immune responses terms strains. Seroconversion seroprotection rates comparable Coad Control groups. Anti-Spike days after receiving similar whether administered alone. Antibody persisted least 6 months post-vaccination reactogenicity profile following consistent known profiles No concerns identified. Coadministration immunogenic well tolerated ≥65 who vaccine. Co-administration an acceptable profile, supporting these Janssen Vaccines & Prevention BV Biomedical Advanced Research Development Authority.
Language: Английский
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Vaccine, Journal Year: 2025, Volume and Issue: 50, P. 126825 - 126825
Published: Feb. 7, 2025
Language: Английский
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Influenza and Other Respiratory Viruses, Journal Year: 2025, Volume and Issue: 19(3)
Published: March 1, 2025
Coadministration of vaccines in children is a long-standing practice that has proven to be safe and effective improving the efficiency vaccine administration, thereby increasing immunization coverage rates. As number routinely recommended for adults increases, with limited opportunities have preventive health touchpoints providers, adult coadministration should considered as routine improve vaccination rates public health. A review existing literature was conducted examine potential reactogenicity impact on effectiveness when co-administering adults. Medline searched research articles search term "influenza vaccine" or "vaccination," combined terms "simultaneous," "concomitant," "concurrent," "combination." Another "vaccination" following individual terms: "RSV," "COVID," "Tdap." The references extracted were also examined other relevant articles. Adult all combinations we assessed. Most adverse events (AEs) generally mild moderate short duration. Some studies showed slightly more but few no serious AEs safety signals. Nearly every study confirmed had significant effect immune response either vaccine. benefits outweigh risks. It increases convenience vaccinees, reduces missed vaccinate, contributes efficient use healthcare resources.
Language: Английский
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International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3119 - 3119
Published: March 28, 2025
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy but continues to face significant challenges that limit its broader application, such as targeting, the tumor microenvironment, and persistence, especially in solid tumors. Meanwhile, global implementation of mRNA vaccines during COVID-19 pandemic highlighted transformative potential lipid nanoparticle (LNP) technologies. These innovations, characterized by their swift development timelines, precise design, efficient delivery mechanisms, provide a promising framework address some limitations CAR-T therapy. Recent advancements, including mRNA-based CAR engineering optimized LNP delivery, have demonstrated capacity enhance efficacy, particularly context This review explores how mRNA-LNP technology can drive vivo engineered therapies current discusses future directions, advancements optimization, strategies for improving functionality safety. By bridging these technological insights, may evolve into versatile accessible treatment paradigm across diverse oncological landscapes.
Language: Английский
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Infectious Diseases and Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Lower respiratory tract infections caused by SARS-CoV-2, influenza, and syncytial virus (RSV) cause a significant disease burden globally, despite the availability of effective vaccines. Certain populations, such as older adults (≥ 60 years) individuals all ages with particular comorbidities, are at increased risk for severe outcomes, including hospitalization death. National administration schedules available vaccines against viruses not unified, current guidelines clear directive, concerning optimal timing vaccination. Herein, we formulate an evidence-based position regarding COVID-19, RSV vaccination chronic based on synthesis literature guidelines. Vaccination impact were found to be influenced vaccinee factors, age waning vaccine effectiveness seasonal pathogen burden. Because display unique patterns within between regions, local epidemiological surveillance each is crucial determining To maximize benefits these vaccines, peak period greatest outcomes should aligned. Thus, other recommended given ahead start season (or regionally appropriate time) co-administered single, routine visit represent approach protecting at-risk populations. More data will required establish clinical benefit additional doses whether may integrated schedule. Coordinated policy decisions that align strain selection new annually reformulated would enable timely raising public health awareness, ultimately leading enhanced uptake. Implementation strategies require engagement healthcare providers strong, recommendations schedules.
Language: Английский
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Published: Jan. 1, 2024
Language: Английский
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