Exploring the Protective Efficacy of Native <i>Acacia catechu</i> Bark Extracts Against Fe<sup>2+</sup> Induced Lipid Peroxidation DOI Open Access
Archana Tiwari, Jyoti Agrawal

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2505 - 2526

Published: Dec. 5, 2024

Background: Acacia catechu is a valuable plant with diverse applications in traditional medicine, industry and ecological management. This abundant the Guna district of central India but lacks scientific research on its phytochemistry, properties, medicinal uses. Aim: The present study analyzed six different bark extracts (methanol, ethanol, aqueous, acetone, chloroform benzene) native for their concentration-dependent, season-dependent (winter, summer, Manson), solvent-dependent Lipid Peroxidation (LPO) inhibition potential. Methods: In this vitro study, Fe2+ ions were used to induce LPO via oxidative stress liver kidney tissue homogenate, end product reaction, i.e., Malondialdehyde (MDA), was measured as MDA formed/hour/mg protein. bibliographic analysis done using dimention.ai database from 1999 June 13th, 2024. Results: results indicated that earlier no has been documented question. experimental work marked increase level FeSO4 treated tubes (p<0.0001), which seen be decreased (p<0.05 or less) well standard drug-treated (p<0.0001). comparative analysis, 125 µl/mg concentration exhibit highest protection (p<0.0001) among all tested concentrations, antioxidative capacity order ethanolic>aqueous>acetone>methanolic>chloroform>benzene extracts, though seasonal impacts inconsistent. Additionally, pattern activity highly correlated (R2 = 0.996) both tissues. Conclusion: current may contribute comprehension utilization characteristics might result notable progress fields medicines, cosmetics, food preservation, agriculture, environmental

Language: Английский

Deep Learning Algorithm‑Based MRI Radiomics and Pathomics for Predicting Microsatellite Instability Status in Rectal Cancer: A Multicenter Study DOI

Xiuzhen Yao,

Shuitang Deng,

Xiaoyu Han

et al.

Academic Radiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4
Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy DOI Creative Commons
Myrna Luna‐Gutiérrez, Erika Azorín‐Vega, Rigoberto Oros‐Pantoja

et al.

EJNMMI Radiopharmacy and Chemistry, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 22, 2025

Cancer immunotherapy is a relatively new approach to cancer treatment. Peptides that target specific pathways and cells involved in immunomodulation can potentially improve the efficacy of therapy. Recently, we reported iPD-L1 as novel inhibitor peptide specifically targets cell ligand PD-L1 (programmed death 1). responsible for inhibiting immune checkpoint protein PD-1 expressed by regulatory T cells. On other hand, anti-PD-L1 combination with external beam radiotherapy has shown improved outcomes treatment breast lung cancer. The aim this research was prepare 177Lu-labeled preclinically evaluate its radiotherapeutic potential role tumor immunomodulator measuring macrophage activation, IL-10, TGFβ, expression 4T1 triple-negative murine tumors after 177Lu-iPD-L1. ligand, characterized UPLC mass, UV-Vis, FT-IR spectroscopies, showed chemical purity 99%. 177Lu-iPD-L1 radiochemical 98.9 ± 1.1%. In vitro vivo studies demonstrated radiotracer stability human serum (> 97% 24 h evaluated radio-HPLC), adequate affinity PDL1 (IC50 = 4.21 nM), detection assessed 4T1, HCT116, AR42J cells, which verified immunofluorescence Western Blot assays. After (0.4 Bq/cell), flow cytometry results significant decrease viability (dead 56.2%) compared 177LuCl3 34.2%) untreated 9.4%). With high uptake (6.97 1.04%ID) hepatobiliary renal clearance, lutetium-177-labeled delivered dose 27 Gy/37 MBq less than 0.36 non-source organs. positive increase activated macrophages, PD-L1, TGFβ levels ELISA assay immunohistochemistry. Therefore, study warrants further dosimetric clinical determine immunomodulatory effect therapeutic treating PD-L1-positive anti-PD-1/PD-L1 protocols.

Language: Английский

Citations

0
Exploring Safety Research Progress and Prospects for the Sustainable Development of Resilient Cities DOI Creative Commons

Bingrui Tong,

Hui Liu, Jun‐Jie Zhu

et al.

Buildings, Journal Year: 2025, Volume and Issue: 15(3), P. 505 - 505

Published: Feb. 6, 2025

In the context of global climate change and accelerated urbanization, construction resilient safe cities has become key to addressing both natural human-made disasters. This literature review systematically analyzes relevant data from city studies published in SCIE SSCI databases 2000 2023, focusing on risk safety perspectives. Using bibliometric tools, spatial–temporal distribution, collaboration networks, knowledge foundations are examined, revealing current state, core topics, emerging trends research. The findings indicate that contemporary research primarily focuses disaster response, infrastructure resilience, community engagement, application big technologies, reflecting a trend toward interdisciplinary integration. not only provides comprehensive theoretical framework for academic but also offers data-driven decision support governments. results highlight directions future research, contributing enhancement urban resilience managing complex risks promoting sustainable development globally.

Language: Английский

Citations

0
Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study DOI Creative Commons

B.K. Gan,

Lei Wu, Shunan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Background Hepatocellular carcinoma (HCC), a prevalent malignancy, is often diagnosed at advanced stages. Recent advances have integrated immunotherapy with targeted therapy, significantly improving treatment outcomes. This study provides bibliometric overview of these therapeutic combinations, evaluating their development and impact. Methods A rigorous selection process was applied to relevant literature from Web Science, followed by in-depth analyses— including timeline visualization, burst detection, co-occurrence analysis—using CiteSpace VOSviewer. approach offered insights into the contributions countries, institutions, authors, journals, references, key terms within field. Results total 506 studies published between 2014 2023 were included, all articles in English. Mainland China dominated publication output, contributing 40% (N = 202), significant United States Japan. Kindai University led institutional contributions, accounting for 7.9% 40). The authors Kudo Masatoshi Hatanaka Takeshi most prolific, each nine publications. journal Cancers emerged as top publisher, 48 an Impact Factor 5.2 2022. co-citation network analysis traced evolution therapy combinations HCC treatment. Early research primarily focused on angiogenesis, dendritic cells, expression markers, while recent trends shifted towards phase III trials, adverse reactions, checkpoint inhibitors, underscoring field’s dynamic progression. Conclusion Future will expand pathological mechanisms underlying therapies novel interventions combination strategies. Addressing events discontinuation remain central advancing clinical applications.

Language: Английский

Citations

0
Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013–2023) DOI Creative Commons

Ruijuan Cai,

Hongsheng Lin, Qiyuan Mao

et al.

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(4)

Published: March 18, 2025

Advances in medical care have made cancer rehabilitation an essential component of comprehensive treatment. However, bibliometric analyses this field remain limited. This study maps the global research landscape over past decade. Relevant publications on from 2013 to 2023 were retrieved Web Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using VOSviewer, CiteSpace, and R package "Bibliometrics." A total 6743 98 countries demonstrated sustained growth, peaking 2022. The USA (1581 publications) China (974) led output, while Netherlands recorded highest citation impact (32.75 citations per paper). Key institutions included University Texas MD Anderson Cancer Center (148 Memorial Sloan Kettering (40.58 Supportive Care ranked as most influential journal. Research efforts primarily focused exercise interventions (n = 404), quality life 688), breast 440). Recent trends highlighted telemedicine, digital health, cancer-related lymphedema. highlights dominance high-income identifies exercise, life, enduring focal points. Emerging priorities include technology-driven lymphedema management. critical gaps remain, such underrepresentation low-resource regions, limited focus pediatric populations, insufficient integration advanced technologies (e.g., AI, wearables). Future should emphasize equitable resource distribution, evidence-based models, scalable solutions address disparities improve survivorship care.

Language: Английский

Citations

0
Mapping knowledge structure and themes trends of corrosion detection of steel: A bibliometric analysis DOI
Wei Chen, Jia Hou,

Shaojin Hao

et al.

Computational Materials Science, Journal Year: 2025, Volume and Issue: 253, P. 113889 - 113889

Published: April 9, 2025

Language: Английский

Citations

0
A Web of Science-Based Bibliometric Analysis Study of Breast Cancer and Psychology DOI

Guanhua Lu,

Shuqi Yang,

Jiabao Chen

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Blockchain Consensus Mechanisms: A Bibliometric Analysis (2014–2024) Using VOSviewer and R Bibliometrix DOI Creative Commons
Joongho Ahn, Eojin Yi, Moonsoo Kim

et al.

Information, Journal Year: 2024, Volume and Issue: 15(10), P. 644 - 644

Published: Oct. 16, 2024

Blockchain consensus mechanisms play a critical role in ensuring the security, decentralization, and integrity of distributed networks. As blockchain technology expands beyond cryptocurrencies into broader applications such as supply chain management healthcare, importance efficient scalable algorithms has grown significantly. This study provides comprehensive bibliometric analysis mechanism research from 2014 to 2024, using tools VOSviewer R’s Bibliometrix package. The traces evolution foundational like Proof ork (PoW) more advanced models Stake (PoS) Byzantine Fault Tolerance (BFT), with particular emphasis on Ethereum’s “The Merge” 2022, which marked historic shift PoW PoS. Key findings highlight emerging themes, including scalability, integration state-of-the-art technologies artificial intelligence (AI), Internet Things (IoT), energy trading. also identifies influential authors, institutions, countries, emphasizing collaborative interdisciplinary nature research. Through thematic analysis, this review uncovers challenges opportunities decentralized systems, underscoring need for continued innovation address efficiency, sustainability, privacy concerns. These insights offer valuable foundation future aimed at advancing across various industries.

Language: Английский

Citations

3
Associations between plasma markers and symptoms of anxiety and depression in patients with breast cancer DOI Creative Commons
Yibo He,

Shangping Cheng,

Lingrong Yang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 11, 2024

Among patients with solid tumors, those breast cancer (BC) experience the most severe psychological issues, exhibiting a high global prevalence of depression that negatively impacts prognosis. Depression can be easily missed, and clinical markers for its diagnosis are lacking. Therefore, this study in order to investigate diagnostic BC anxiety explore specific changes metabolism. Thirty-eight thirty-six matched healthy controls were included study. The symptoms participants evaluated by 17-item Hamilton Scale (HAMD-17) Anxiety (HAMA). Plasma levels glial fibrillary acidic protein (GFAP) lipocalin-2 (LCN2) using enzyme linked immunosorbent assay, plasma lactate metabolic characteristics analyzed. This revealed GFAP LCN2 may good or also marker anxiety. In addition, metabolism preliminarily explored.

Language: Английский

Citations

2
Knowledge mapping of immunotherapy for breast cancer: A bibliometric analysis from 2013 to 2022: A correspondence DOI Creative Commons

Ruochen Bao,

Hongtao Qu, Baifeng Li

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: May 16, 2024

Language: Английский

Citations

1