Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)
Published: Oct. 7, 2024
Language: Английский
Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)
Published: Feb. 5, 2025
Cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism, and its activity has been linked to the risk of atherosclerosis (AS). CETP inhibitors, such as obicetrapib, represent novel approach immunotherapy reduce atherosclerotic cardiovascular disease (ASCVD) by targeting lipid metabolism. In addition, vaccines are being explored strategy for prevention treatment ASCVD inducing body produce antibodies against CETP, which is expected activity, thereby increasing high-density lipoproteins (HDL) levels. This paper provides comprehensive overview structure mechanisms progress last decade, possible ideas future development drugs optimization immunization strategies.
Language: Английский
Citations
0
Combustion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: March 27, 2025
Language: Английский
Citations
0
Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)
Published: Aug. 14, 2024
Language: Английский
Citations
2
Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)
Published: Oct. 7, 2024
Language: Английский
Citations
2
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 12, 2024
Background Noonan syndrome (NS) is a rare group of autosomal genetic disorders. In recent years, with the exploration and development molecular diagnostic techniques, more researchers have begun to pay attention NS. However, there still lack reports on bibliometric analysis NS worldwide. This study aims assess current research status trend NS, explore hotspots emerging topics, point out direction for future scientific research. Methods Web Science Core Collection was selected as search database NS-related publications from 1998 2023. Statistical visual number publications, countries, institutions, authors, journals, keywords, references were analyzed using Citespace, VOSviewer, Scimago Graphica, BibliometrixR. Results A total 2041 articles included in this study. The United States had highest Istituto Superiore di Sanità, Italy, institution publications. TARTAGLIA M scientist citations. Among AMERICAN JOURNAL OF MEDICAL GENETICS PART has output, Nature Genetics most frequently cited. reference outburst intensity Roberts AE, LANCET, 2013. cluster diagram divides all keywords into seven categories, vigorous being “of function mutations.” Conclusion Research field focus correspondence between genotype phenotype precise diagnosis Future efforts will deeply perspective long-term intervention strategies There an urgent need rely significant authors lead construction robust global collaborative network that enhance efficacy.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1637 - 1637
Published: Dec. 20, 2024
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol-lowering therapies. As is marked by chronic arterial inflammation, the innate adaptive immune systems play vital roles in progression, either exacerbating or alleviating development. This intricate interplay positions system as compelling therapeutic target. Consequently, immunomodulatory strategies have gained increasing attention, though none yet reached widespread clinical adoption. Safety concerns, particularly suppression of host defenses, remain significant barrier to application anti-inflammatory Recent decades revealed role responses plaque-associated autoantigens atherogenesis, opening new perspectives for targeted immunological interventions. Preclinical models indicate that vaccines targeting specific atherosclerosis-related can slow progression while preserving systemic function. In this context, numerous experimental studies advanced understanding vaccine development exploring diverse pathways. Key include passive immunization using naturally occurring immunoglobulin G (IgG) antibodies active low-density lipoprotein cholesterol (LDL-C) apolipoproteins, such apolipoprotein B100 (ApoB100) CIII (ApoCIII). Other approaches involve formulations aimed at proteins regulate metabolism, including proprotein convertase subtilisin/kexin type 9 (PCSK9), cholesteryl ester transfer protein (CETP), angiopoietin-like 3 (ANGPTL3). Furthermore, literature highlights potential developing non-lipid-related vaccines, key targets heat shock (HSPs), interleukins (ILs), angiotensin III (Ang III), disintegrin metalloproteinase thrombospondin motifs 7 (ADAMTS-7). However, translating these promising findings into safe effective therapies presents substantial challenges. review provides critical evaluation current anti-atherosclerotic vaccination strategies, examines their proposed mechanisms action, discusses challenges need be overcome enable translation.
Language: Английский
Citations
1
Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)
Published: Aug. 8, 2024
Language: Английский
Citations
0
Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)
Published: Oct. 7, 2024
Language: Английский
Citations
0