Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations DOI Creative Commons

Jiqian Xu,

Wanying Zhang,

Jiaji Fu

et al.

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 16, 2024

Abstract Sepsis, characterized as life-threatening organ dysfunction resulting from dysregulated host responses to infection, remains a significant challenge in clinical practice. Despite advancements understanding host-bacterial interactions, molecular responses, and therapeutic approaches, the mortality rate associated with sepsis has consistently ranged between 10 16%. This elevated highlights critical gaps our comprehension of etiology. Traditionally linked bacterial fungal pathogens, recent outbreaks acute viral infections, including Middle East respiratory syndrome coronavirus (MERS-CoV), influenza virus, severe 2 (SARS-CoV-2), among other regional epidemics, have underscored role pathogenesis sepsis, particularly when critically ill patients exhibit classic symptoms indicative sepsis. However, many cases viral-induced are frequently underdiagnosed because standard evaluations typically exclude panels. Moreover, these viruses not only activate conventional pattern recognition receptors (PRRs) retinoic acid-inducible gene-I (RIG-I)-like (RLRs) but also initiate primary antiviral pathways such cyclic guanosine monophosphate adenosine (GMP-AMP) synthase (cGAS)-stimulator interferon genes (STING) signaling response mechanisms. Such activations lead cellular stress, metabolic disturbances, extensive cell damage that exacerbate tissue injury while leading spectrum manifestations. complexity poses substantial challenges for management affected cases. In this review, we elucidate definition diagnosis criteria synthesizing current knowledge regarding its etiology, epidemiology, pathophysiology, mechanisms involved therein well their impact on immune-mediated damage. Additionally, discuss considerations related both existing therapies advanced treatment interventions, aiming enhance comprehensive surrounding

Language: Английский

Update on vaccines against respiratory syncytial virus (RSV): A narrative review DOI

José Gutierrez-Rodriguez,

Jaime Rodríguez-Salazar,

Francisco José Tarazona‐Santabalbina

et al.

Revista Española de Geriatría y Gerontología, Journal Year: 2025, Volume and Issue: 60(2), P. 101630 - 101630

Published: Feb. 11, 2025

Language: Английский

Citations

0
Mexican Interdisciplinary Consensus on the Diagnosis and Preventive Measures for Respiratory Syncytial Virus Infections DOI Creative Commons
Rosa María Wong‐Chew, Daniel E. Noyola, Fortino Solórzano‐Santos

et al.

Archives of Medical Research, Journal Year: 2025, Volume and Issue: 56(4), P. 103183 - 103183

Published: Feb. 20, 2025

Respiratory syncytial virus (RSV) is a common cause of respiratory illness in children and adults Latin America Mexico. RSV circulates with seasonal peaks fall winter. Individuals at highest risk for severe infection are premature infants those comorbidities, as well older cardiopulmonary pathologies and/or varying degrees immunocompromise. To provide an updated landscape the epidemiology, groups, diagnostic methods, prevention Convened by Asociación Mexicana de Infectología y Microbiología Clínica, 28 interdisciplinary experts participated consensus meeting held November 2023. Four each seven medical writer, were formed to discuss epidemiology diagnosis, vaccines, monoclonal antibodies (mABs). Predefined questions, formulated team four experts, discussed within group, was reached on answers. These responses then analyzed organized into recommendations based national international evidence. Evidence-based epidemiological surveillance, proposed. Future perspectives regarding usefulness new vaccines passive immunoprophylaxis analyzed. Timely identification at-risk populations, diagnosis treatment infection, particularly rational use mABs key strategies reduce clinical burden infection.

Language: Английский

Citations

0
Perceived benefits, information, vaccination history, and conspiracy beliefs as significant determinants of RSV vaccine acceptance among Arab seniors DOI Creative Commons
Malik Sallam,

Kholoud Al-Mahzoum,

Zainab Mansour Yousef

et al.

Therapeutic Advances in Vaccines and Immunotherapy, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Background: Respiratory syncytial virus (RSV) poses a significant respiratory health risk to senior citizens, contributing substantially hospitalizations and mortality. With the recent approval of three RSV vaccines for elderly, it is critical understand factors that can shape vaccination attitudes inform public strategies enhance uptake among this vulnerable population. Objectives: This study aimed investigate potential could influence toward citizens in Arab countries. Design: A multinational cross-sectional study, adhering STROBE guidelines, was conducted using survey instrument previously validated through exploratory factor analysis assess newly approved vaccine. Methods: self-administered online distributed conveniently mainly across five The collected data on demographics, history, key constructs related vaccine attitude, including “Fear,” “Information,” “Accessibility,” “Benefits,” “Conspiracy.” Results: total 483 participants were included with majority from countries: Jordan ( n = 239, 49.5%), Kuwait 74, 15.3%), Egypt 68, 14.1%), Saudi Arabia 51, 10.6%), UAE 23, 4.8%), alongside other nations 28, 5.8%). Among respondents, 51.1% 247) expressed acceptance vaccine, 22.4% 108) hesitant, 26.5% 128) exhibited refusal. Multivariate identified perceived benefits (β 0.484, p < 0.001), information needs 0.229, previous history 0.087, 0.016) as positive predictors acceptance. Conversely, stronger conspiracy beliefs −0.083, 0.035) associated resistance. Fear accessibility not attitudes. Conclusion: findings showed benefits, access reliable information, are essential promote seniors. These recommended improve

Language: Английский

Citations

0
Knowledge, attitude, and perception regarding the respiratory syncytial virus vaccine among healthcare professionals DOI Creative Commons
Khawla Abu Hammour,

Qusai Manaseer,

Mariam Abdeljalil

et al.

Journal of Pharmaceutical Policy and Practice, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 28, 2025

Respiratory syncytial virus (RSV) is a significant respiratory pathogen. Despite vaccine availability, uptake remains low, and healthcare professionals play key role in promoting immunisation. This study aims to evaluate providers' knowledge, perceptions practices regarding the RSV vaccine. A validated survey was distributed professionals. The questionnaire contained sections assess sociodemographic characteristics, knowledge of its vaccines, professionals' perception towards their potential barriers against vaccination. last section assesses physicians' previous practice dealing with infection. Over half participants (56.6%) had no prior awareness RSV, though many recognised severity, particularly vulnerable populations like children older adults (52.6%). Awareness FDA-approved vaccines limited, only 28.1% respondents familiar intended for adults. Views on vaccination recommendations age groups were divided; 23.7% supported those 75 older, while 31.1% advocated aged 60-74 at higher risk. Perceived prominent. Most (85.1%) cited concerns about safety as obstacle, 81.1% identified out-of-pocket costs barrier. Testing infrequent (24.6%), mainly due lack effective treatment. (96.9%) called greater education 91.2% recommending if it available free. reveals gaps substantial adoption. Targeted education, improved diagnostics, addressing are essential strategies improving response RSV.

Language: Английский

Citations

0
Vaccination during febrile illness, what do we know? A systematic-narrative hybrid review of the literature and international recommendations DOI

Soumaya Essalim,

Chloe Tachet,

Sarah Demingo

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(26), P. 126473 - 126473

Published: Oct. 24, 2024

Language: Английский

Citations

1
Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations DOI Creative Commons

Jiqian Xu,

Wanying Zhang,

Jiaji Fu

et al.

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 16, 2024

Abstract Sepsis, characterized as life-threatening organ dysfunction resulting from dysregulated host responses to infection, remains a significant challenge in clinical practice. Despite advancements understanding host-bacterial interactions, molecular responses, and therapeutic approaches, the mortality rate associated with sepsis has consistently ranged between 10 16%. This elevated highlights critical gaps our comprehension of etiology. Traditionally linked bacterial fungal pathogens, recent outbreaks acute viral infections, including Middle East respiratory syndrome coronavirus (MERS-CoV), influenza virus, severe 2 (SARS-CoV-2), among other regional epidemics, have underscored role pathogenesis sepsis, particularly when critically ill patients exhibit classic symptoms indicative sepsis. However, many cases viral-induced are frequently underdiagnosed because standard evaluations typically exclude panels. Moreover, these viruses not only activate conventional pattern recognition receptors (PRRs) retinoic acid-inducible gene-I (RIG-I)-like (RLRs) but also initiate primary antiviral pathways such cyclic guanosine monophosphate adenosine (GMP-AMP) synthase (cGAS)-stimulator interferon genes (STING) signaling response mechanisms. Such activations lead cellular stress, metabolic disturbances, extensive cell damage that exacerbate tissue injury while leading spectrum manifestations. complexity poses substantial challenges for management affected cases. In this review, we elucidate definition diagnosis criteria synthesizing current knowledge regarding its etiology, epidemiology, pathophysiology, mechanisms involved therein well their impact on immune-mediated damage. Additionally, discuss considerations related both existing therapies advanced treatment interventions, aiming enhance comprehensive surrounding

Language: Английский

Citations

1