Meta‐Analysis: Global Prevalence of Coeliac Disease in Type 1 Diabetes
Alimentary Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
ABSTRACT
Background
Coeliac
disease
(CD)
is
common
in
patients
with
type
1
diabetes
(T1D),
but
prevalence
varies
globally
due
to
differing
screening
protocols.
There
have
been
substantial
changes
guidelines
over
the
past
two
decades.
Aim
To
evaluate
CD
T1D,
focusing
on
studies
using
antitissue
transglutaminase
(anti‐tTG)
antibody.
Methods
We
searched
PubMed,
Web
of
Science,
Embase
and
Scopus
for
published
up
11
December
2023
keywords
related
diabetes.
used
random‐effects
models
overall
all
subgroups,
heterogeneity
assessed
Cochran's
Q
test
I
2
statistic
performed
STATA
18.
Results
included
106
articles
involving
65,102
T1D
across
40
countries.
The
pooled
seroprevalence
confirmed
were
9%
(95%
confidence
interval,
CI,
8%–10%)
6%
CI
5%–7%),
respectively.
was
higher
females
children.
Denmark,
Saudi
Arabia
Libya
exhibited
highest
(11%),
followed
by
India
Egypt
(10%).
Belgium,
France,
Germany,
South
Africa
United
States
had
lowest
(2%).
High‐income
countries
showed
significantly
a
lower
than
middle‐income
(
p
=
0.03).
Meta‐regression
based
Human
Development
Index
(HDI)
indicated
that
HDI
prevalence.
Conclusion
Approximately
16
12
Asia
Middle
East
has
CD.
suggest
should
be
screened
Language: Английский
Circulating MicroRNAs and Cytokines Associated with Celiac Disease
Middle East Journal of Digestive Diseases,
Journal Year:
2024,
Volume and Issue:
16(3), P. 185 - 192
Published: July 31, 2024
The
current
research
examines
the
molecular
terrain
of
celiac
disease
(CD)
through
microRNA
(miRNA)
and
cytokines
as
potential
new
diagnostic
therapeutic
markers.
Gluten-appropriate
immune
response
is
a
key
feature
an
autoimmune
clinical
entity
known
CD
that
leads
to
inflammation
degeneration
small
intestine
mucosa.
However,
mechanisms
responsible
for
this
remain
unclear.
Language: Английский