Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis DOI Open Access
Karla A. Bascuñán,

Magdalena Araya,

Juan M. Corchado

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 621 - 621

Published: Feb. 9, 2025

Celiac disease (CD) is a chronic autoimmune disorder driven by both genetic and environmental factors, with the HLA DQ2/DQ8 genotypes playing central role in its development. Despite predisposition, only small percentage of individuals carrying these develop disease. Gluten, protein found wheat, rye, barley, primary trigger, but other such as intestinal microbiota, may also contribute to progression. While gluten-free diet (GFD) remains cornerstone treatment, many CD patients experience persistent inflammation gut dysbiosis, leading ongoing symptoms complications. This inflammation, which impairs nutrient absorption, increases risk malnutrition, anemia, disorders. Recent studies have identified an altered microbiota patients, on off GFD, highlighting potential pathogenesis. An emerging area interest supplementation n-3 polyunsaturated fatty acids (PUFAs), known for their anti-inflammatory properties, therapeutic strategy. PUFAs, fish oil certain plant oils, modulate immune cell function cytokine production, making them promising intervention controlling CD. review explores current understanding PUFAs' effects microbiota's composition CD, goal identifying new avenues complementary treatments improve management.

Language: Английский

Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis DOI Open Access
Karla A. Bascuñán,

Magdalena Araya,

Juan M. Corchado

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 621 - 621

Published: Feb. 9, 2025

Celiac disease (CD) is a chronic autoimmune disorder driven by both genetic and environmental factors, with the HLA DQ2/DQ8 genotypes playing central role in its development. Despite predisposition, only small percentage of individuals carrying these develop disease. Gluten, protein found wheat, rye, barley, primary trigger, but other such as intestinal microbiota, may also contribute to progression. While gluten-free diet (GFD) remains cornerstone treatment, many CD patients experience persistent inflammation gut dysbiosis, leading ongoing symptoms complications. This inflammation, which impairs nutrient absorption, increases risk malnutrition, anemia, disorders. Recent studies have identified an altered microbiota patients, on off GFD, highlighting potential pathogenesis. An emerging area interest supplementation n-3 polyunsaturated fatty acids (PUFAs), known for their anti-inflammatory properties, therapeutic strategy. PUFAs, fish oil certain plant oils, modulate immune cell function cytokine production, making them promising intervention controlling CD. review explores current understanding PUFAs' effects microbiota's composition CD, goal identifying new avenues complementary treatments improve management.

Language: Английский

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