Integrated Analysis of Noncoding RNAs (PVT-1 and miR-200c) and Their Correlation with STAT4/IL-6 Axis as Reliable Biomarkers for COVID-19 Severity DOI
Ghada Ayeldeen, Bahaa Badr, Mohamed R. Herzalla

et al.

Journal of Interferon & Cytokine Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Inefficient control of elevated inflammatory mediators in coronavirus disease 2019 (COVID-19) has led to health complications, prompting the exploration efficient biomarkers for monitoring this condition. We herein sought investigate implications plasmacytoma variant translocation 1 (PVT-1), microRNA-200c (miR-200c), signal transducer and activator transcription 4 (STAT-4), interleukin-6 (IL-6), as well how they correlated with creatinine, C-reactive protein (CRP), lactate dehydrogenase (LDH) activity identify able early prognosis diagnosis COVID-19. Our study included a total 105 infected COVID-19 patients 35 healthy subjects controls. Individuals showed significant increase CRP, LDH activity. In addition, exhibited significantly higher levels IL-6. These also demonstrated notably expressions miR-200c PVT-1. The expression level STAT4 decreased patients, decrease was negatively creatinine PVT-1 expressions, their connections IL-6 levels, increased severity cases. receiver operating characteristic analysis that could be reliable determining

Language: Английский

Integrated Analysis of Noncoding RNAs (PVT-1 and miR-200c) and Their Correlation with STAT4/IL-6 Axis as Reliable Biomarkers for COVID-19 Severity DOI
Ghada Ayeldeen, Bahaa Badr, Mohamed R. Herzalla

et al.

Journal of Interferon & Cytokine Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Inefficient control of elevated inflammatory mediators in coronavirus disease 2019 (COVID-19) has led to health complications, prompting the exploration efficient biomarkers for monitoring this condition. We herein sought investigate implications plasmacytoma variant translocation 1 (PVT-1), microRNA-200c (miR-200c), signal transducer and activator transcription 4 (STAT-4), interleukin-6 (IL-6), as well how they correlated with creatinine, C-reactive protein (CRP), lactate dehydrogenase (LDH) activity identify able early prognosis diagnosis COVID-19. Our study included a total 105 infected COVID-19 patients 35 healthy subjects controls. Individuals showed significant increase CRP, LDH activity. In addition, exhibited significantly higher levels IL-6. These also demonstrated notably expressions miR-200c PVT-1. The expression level STAT4 decreased patients, decrease was negatively creatinine PVT-1 expressions, their connections IL-6 levels, increased severity cases. receiver operating characteristic analysis that could be reliable determining

Language: Английский

Citations

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