Pandanus Amaryllifolius Roxb. Polyphenol Extract Alleviates NAFLD via Regulating Gut Microbiota and AMPK/AKT/mTOR Signaling Pathway DOI Creative Commons
Jinji Lin, Fei Ren,

Mengxu Zhu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1000 - 1000

Published: March 15, 2025

With the drastic changes in lifestyle, nonalcoholic fatty liver disease (NAFLD) has become a widespread health problem. Natural actives such as polyphenols have multi-target, multi-mechanism characteristics, and offer new opportunities for NAFLD treatment. This study established high-fat diet (HFD)-induced model mice to investigate molecular mechanism of Pandanus amaryllifolius Roxb. polyphenol extract (PAE) alleviating NAFLD. The results showed that PAE significantly inhibited HFD-induced obesity, maintained glucose homeostasis, mitigated oxidative damage tissue, reduced steatosis. Moreover, treatment remarkably reversed 16 endogenous DMs, affected glycerophospholipid metabolism, which increased levels phosphatidylcholine phosphatidylethanolamine, down-regulated choline sn-glyceropl-3P. Further validation revealed was able prevent progression by regulating AMPK/AKT/mTOR signaling pathway enhance autophagy levels. Meanwhile, restored balance gut microbiota mainly increasing relative abundance Bacteroidetes, decreasing Firmicutes ratio Firmicutes/Bacteroidetes. Overall, findings highlight alleviates may be related regulation microbes pathway, enriching health-promoting effects on

Language: Английский

Pandanus Amaryllifolius Roxb. Polyphenol Extract Alleviates NAFLD via Regulating Gut Microbiota and AMPK/AKT/mTOR Signaling Pathway DOI Creative Commons
Jinji Lin, Fei Ren,

Mengxu Zhu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1000 - 1000

Published: March 15, 2025

With the drastic changes in lifestyle, nonalcoholic fatty liver disease (NAFLD) has become a widespread health problem. Natural actives such as polyphenols have multi-target, multi-mechanism characteristics, and offer new opportunities for NAFLD treatment. This study established high-fat diet (HFD)-induced model mice to investigate molecular mechanism of Pandanus amaryllifolius Roxb. polyphenol extract (PAE) alleviating NAFLD. The results showed that PAE significantly inhibited HFD-induced obesity, maintained glucose homeostasis, mitigated oxidative damage tissue, reduced steatosis. Moreover, treatment remarkably reversed 16 endogenous DMs, affected glycerophospholipid metabolism, which increased levels phosphatidylcholine phosphatidylethanolamine, down-regulated choline sn-glyceropl-3P. Further validation revealed was able prevent progression by regulating AMPK/AKT/mTOR signaling pathway enhance autophagy levels. Meanwhile, restored balance gut microbiota mainly increasing relative abundance Bacteroidetes, decreasing Firmicutes ratio Firmicutes/Bacteroidetes. Overall, findings highlight alleviates may be related regulation microbes pathway, enriching health-promoting effects on

Language: Английский

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