The Current Status of T Cell Receptor (TCR) Repertoire Analysis in Colorectal Cancer DOI Open Access

Hiroyuki Takahashi,

Katsuzo Hanaoka,

Hideo Wada

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2698 - 2698

Published: March 17, 2025

The rapid increase in colorectal cancer (CRC) cases recently has highlighted the need to use predictive biomarkers guide therapeutic approaches. Current studies have focused on tumor-infiltrating lymphocytes present tumor microenvironment (TME), which cytotoxic T cell activation and amount are associated with CRC patient prognosis. receptor (TCR) is essential for antigen recognition identification, playing a central role immunotherapy. status reflects TCR diversity or clonality, known as repertoire. Accordingly, analyzing repertoire dynamics may help predict immunological circumstances of TME timely way. In this review, we summarize repertoire-related knowledge, including its potential CRC. intratumoral restricted patients compared healthy individuals, well peripheral blood. Patients deficient mismatch repair display more restriction than those proficient repair. Importantly, higher before treatment decrease following indicate good response better clinical outcome patients. future sequencing technology combined artificial intelligence-based analysis strategy decision making.

Language: Английский

The Current Status of T Cell Receptor (TCR) Repertoire Analysis in Colorectal Cancer DOI Open Access

Hiroyuki Takahashi,

Katsuzo Hanaoka,

Hideo Wada

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2698 - 2698

Published: March 17, 2025

The rapid increase in colorectal cancer (CRC) cases recently has highlighted the need to use predictive biomarkers guide therapeutic approaches. Current studies have focused on tumor-infiltrating lymphocytes present tumor microenvironment (TME), which cytotoxic T cell activation and amount are associated with CRC patient prognosis. receptor (TCR) is essential for antigen recognition identification, playing a central role immunotherapy. status reflects TCR diversity or clonality, known as repertoire. Accordingly, analyzing repertoire dynamics may help predict immunological circumstances of TME timely way. In this review, we summarize repertoire-related knowledge, including its potential CRC. intratumoral restricted patients compared healthy individuals, well peripheral blood. Patients deficient mismatch repair display more restriction than those proficient repair. Importantly, higher before treatment decrease following indicate good response better clinical outcome patients. future sequencing technology combined artificial intelligence-based analysis strategy decision making.

Language: Английский

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