Vacuolar protein sorting 13 homolog C was associated with motor progression in Parkinson’s Disease DOI

Xin Guo,

Bin Teng, Jianfang Ma

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 131, P. 107253 - 107253

Published: Dec. 28, 2024

Language: Английский

Key genes and convergent pathogenic mechanisms in Parkinson disease DOI
Robert Coukos, Dimitri Krainc

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(6), P. 393 - 413

Published: April 10, 2024

Language: Английский

Citations

25
Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C DOI Open Access
Xinbo Wang, Peng Xu, Amanda Bentley‐DeSousa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson's disease (PD). Here we show that VPS13C, bridge-like lipid transport protein and PD gene, sensor of stress/damage. Upon membrane perturbation, VPS13C rapidly relocates from the cytosol surface lysosomes where it tethers their membranes ER. This recruitment depends Rab7 requires signal at damaged releases an inhibited state which hinders access its VAB domain lysosome-bound Rab7. While another protein, LRRK2, also recruited stressed/damaged lysosomes, occurs much later stages by different mechanisms. Given VPS13 proteins bulk transport, these findings suggest delivery part early protective response damage.

Language: Английский

Citations

12
Phosphorylated Eriocheir sinensis Rab10 regulates apoptosis and phagocytosis to defense Spiroplasma eriocheiris infection DOI
Yubo Ma, Qing Yun Li, Xiaotong Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141527 - 141527

Published: Feb. 26, 2025

Language: Английский

Citations

0
Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson’s disease models DOI Creative Commons
Ge Gao, Yongyong Shi, Han‐Xiang Deng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

Dysregulation of mitochondrial function has been implicated in Parkinson's disease (PD), but the role metabolism pathogenesis remains to be elucidated. Using an unbiased metabolomic analysis purified mitochondria, we identified alterations α-ketoglutarate dehydrogenase (KGDH) pathway upon loss PD-linked CHCHD2 protein. KGDH, a rate-limiting enzyme complex tricarboxylic acid cycle, was decreased CHCHD2-deficient male mouse brains and human dopaminergic neurons. This deficiency KGDH led elevated increased lipid peroxidation. Treatment neurons with lipoic acid, cofactor antioxidant agent, resulted levels peroxidation phosphorylated α-synuclein. CHCHD10, close homolog that is primarily linked amyotrophic lateral sclerosis/frontotemporal dementia, did not affect or Together, these results identify metabolic as targetable mechanism for correction α-synuclein disease. An identifies CHCHD2-linked models.

Language: Английский

Citations

0
The phosphomimetic Rab10 T73D mutation in mice leads to postnatal lethality and aberrations in neuronal development DOI
Dan Han, Jing Zhang, Yuan Zheng

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167830 - 167830

Published: April 1, 2025

Language: Английский

Citations

0
Commander complex regulates lysosomal function and is implicated in Parkinson’s disease risk DOI
Georgia Minakaki, Nathaniel Safren, Bernabé I. Bustos

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6743), P. 204 - 211

Published: April 10, 2025

Variants in GBA1 resulting decreased lysosomal glucocerebrosidase (GCase) activity are a common risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Incomplete penetrance of variants suggests that additional genes contribute to PD DLB manifestation. By using pooled genome-wide CRISPR interference screen, we identified copper metabolism MURR1 domain–containing 3 (COMMD3) protein, component the COMMD/coiled-coil protein 22 (CCDC22)/CCDC93 (CCC) Commander complexes, as modifier GCase activity. Loss COMMD3 increased release proteins through extracellular vesicles, leading their impaired delivery endolysosomes consequent dysfunction. Rare gene family were associated risk. Thus, COMMD related complexes regulate homeostasis may represent modifiers other neurodegenerative diseases

Language: Английский

Citations

0
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage DOI Creative Commons

X.F. Wang,

Peng Xu, Amanda Bentley‐DeSousa

et al.

Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0
Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis DOI

Sumit Bandyopadhyay,

Daniel Adebayo,

Eseiwi Obaseki

et al.

Current topics in membranes, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 116

Published: Jan. 1, 2024

Language: Английский

Citations

2
Full-length circRNA sequencing method using low-input RNA and profiling of circRNAs in MPTP-PD mice on nanopore platform DOI
Ying Wang, Xiaohan Li, Wenxiang Lu

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 149(20), P. 5118 - 5130

Published: Jan. 1, 2024

An effective method to characterize full-length circRNA sequences from low-input RNA samples with rolling circular reverse transcription and nanopore sequencing.

Language: Английский

Citations

0
Vacuolar protein sorting 13 homolog C was associated with motor progression in Parkinson’s Disease DOI

Xin Guo,

Bin Teng, Jianfang Ma

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 131, P. 107253 - 107253

Published: Dec. 28, 2024

Language: Английский

Citations

0