Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

Published: Feb. 14, 2025

Neural lamination is a common feature of the central nervous system (CNS), with several subcellular structures, such as adherens junctions (AJs), playing role in this process. The retina also heavily laminated, but it remains unclear how laminar formation impacts retinal cell morphology, synapse integrity, and overall function. In study, we demonstrate that loss afadin, key component AJs, leads to significant pathological changes. These include disruption outer notable decrease well mislocalization photoreceptors, their segments, photoreceptor synapses. Interestingly, despite these severe impairments, recorded small local field potentials, including a- b-waves. We classified ganglion cells into ON, ON-OFF, OFF types based on firing patterns response light stimuli. Additionally, successfully characterized receptive fields certain cells. Overall, findings provide first evidence circuit function can be partially preserved even when there are disruptions Our results indicate retinas severely altered morphology still retain some capacity process

Language: Английский

Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

Published: Feb. 14, 2025

Neural lamination is a common feature of the central nervous system (CNS), with several subcellular structures, such as adherens junctions (AJs), playing role in this process. The retina also heavily laminated, but it remains unclear how laminar formation impacts retinal cell morphology, synapse integrity, and overall function. In study, we demonstrate that loss afadin, key component AJs, leads to significant pathological changes. These include disruption outer notable decrease well mislocalization photoreceptors, their segments, photoreceptor synapses. Interestingly, despite these severe impairments, recorded small local field potentials, including a- b-waves. We classified ganglion cells into ON, ON-OFF, OFF types based on firing patterns response light stimuli. Additionally, successfully characterized receptive fields certain cells. Overall, findings provide first evidence circuit function can be partially preserved even when there are disruptions Our results indicate retinas severely altered morphology still retain some capacity process

Language: Английский

Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

The nectin family of cell adhesion molecules (CAMs) comprising nectins and nectin-like has emerged as a key regulator various pivotal neural processes, including neuronal development, migration, synapse formation, plasticity. Nectins engage in homophilic heterophilic interactions to mediate cell-cell adhesion, contributing the establishment maintenance circuits. Their extracellular domains facilitate trans-synaptic interactions, while intracellular participate signaling cascades influencing cytoskeletal dynamics synaptic function. exhibition distinct localization patterns neurons, astrocytes, blood-brain barrier underscores their diverse roles brain. dysregulation been implicated several neurological disorders, such neurodevelopmental depression, schizophrenia, Alzheimer's disease. This review examines structural functional characteristics distribution molecular mechanisms governing connectivity cognition. It further discusses experimental studies unraveling nectin-mediated pathophysiology potential therapeutic interventions targeting nectin-related pathways. Collectively, this comprehensive analysis highlights significance brain function, paving way for future research directions clinical implications.

Language: Английский