Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Akiko Ueno,
No information about this author
Konan Sakuta,
No information about this author
Ono H
No information about this author
et al.
Published: Feb. 14, 2025
Neural
lamination
is
a
common
feature
of
the
central
nervous
system
(CNS),
with
several
subcellular
structures,
such
as
adherens
junctions
(AJs),
playing
role
in
this
process.
The
retina
also
heavily
laminated,
but
it
remains
unclear
how
laminar
formation
impacts
retinal
cell
morphology,
synapse
integrity,
and
overall
function.
In
study,
we
demonstrate
that
loss
afadin,
key
component
AJs,
leads
to
significant
pathological
changes.
These
include
disruption
outer
notable
decrease
well
mislocalization
photoreceptors,
their
segments,
photoreceptor
synapses.
Interestingly,
despite
these
severe
impairments,
recorded
small
local
field
potentials,
including
a-
b-waves.
We
classified
ganglion
cells
into
ON,
ON-OFF,
OFF
types
based
on
firing
patterns
response
light
stimuli.
Additionally,
successfully
characterized
receptive
fields
certain
cells.
Overall,
findings
provide
first
evidence
circuit
function
can
be
partially
preserved
even
when
there
are
disruptions
Our
results
indicate
retinas
severely
altered
morphology
still
retain
some
capacity
process
Language: Английский
Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Akiko Ueno,
No information about this author
Konan Sakuta,
No information about this author
Ono H
No information about this author
et al.
Published: Feb. 14, 2025
Neural
lamination
is
a
common
feature
of
the
central
nervous
system
(CNS),
with
several
subcellular
structures,
such
as
adherens
junctions
(AJs),
playing
role
in
this
process.
The
retina
also
heavily
laminated,
but
it
remains
unclear
how
laminar
formation
impacts
retinal
cell
morphology,
synapse
integrity,
and
overall
function.
In
study,
we
demonstrate
that
loss
afadin,
key
component
AJs,
leads
to
significant
pathological
changes.
These
include
disruption
outer
notable
decrease
well
mislocalization
photoreceptors,
their
segments,
photoreceptor
synapses.
Interestingly,
despite
these
severe
impairments,
recorded
small
local
field
potentials,
including
a-
b-waves.
We
classified
ganglion
cells
into
ON,
ON-OFF,
OFF
types
based
on
firing
patterns
response
light
stimuli.
Additionally,
successfully
characterized
receptive
fields
certain
cells.
Overall,
findings
provide
first
evidence
circuit
function
can
be
partially
preserved
even
when
there
are
disruptions
Our
results
indicate
retinas
severely
altered
morphology
still
retain
some
capacity
process
Language: Английский
Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders
ACS Chemical Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 2, 2025
The
nectin
family
of
cell
adhesion
molecules
(CAMs)
comprising
nectins
and
nectin-like
has
emerged
as
a
key
regulator
various
pivotal
neural
processes,
including
neuronal
development,
migration,
synapse
formation,
plasticity.
Nectins
engage
in
homophilic
heterophilic
interactions
to
mediate
cell-cell
adhesion,
contributing
the
establishment
maintenance
circuits.
Their
extracellular
domains
facilitate
trans-synaptic
interactions,
while
intracellular
participate
signaling
cascades
influencing
cytoskeletal
dynamics
synaptic
function.
exhibition
distinct
localization
patterns
neurons,
astrocytes,
blood-brain
barrier
underscores
their
diverse
roles
brain.
dysregulation
been
implicated
several
neurological
disorders,
such
neurodevelopmental
depression,
schizophrenia,
Alzheimer's
disease.
This
review
examines
structural
functional
characteristics
distribution
molecular
mechanisms
governing
connectivity
cognition.
It
further
discusses
experimental
studies
unraveling
nectin-mediated
pathophysiology
potential
therapeutic
interventions
targeting
nectin-related
pathways.
Collectively,
this
comprehensive
analysis
highlights
significance
brain
function,
paving
way
for
future
research
directions
clinical
implications.
Language: Английский