From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Cell, Journal Year: 2016, Volume and Issue: 165(6), P. 1332 - 1345

Published: June 1, 2016

Language: Английский

---

AKT/PKB Signaling: Navigating the Network

Cell, Journal Year: 2017, Volume and Issue: 169(3), P. 381 - 405

Published: April 1, 2017

Language: Английский

---

MYC on the Path to Cancer

Cell, Journal Year: 2012, Volume and Issue: 149(1), P. 22 - 35

Published: March 1, 2012

Language: Английский

---

A guide to immunometabolism for immunologists

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(9), P. 553 - 565

Published: July 11, 2016

Language: Английский

---

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

Immunity, Journal Year: 2011, Volume and Issue: 35(6), P. 871 - 882

Published: Dec. 1, 2011

Language: Английский

---

Metabolic Pathways in Immune Cell Activation and Quiescence

Immunity, Journal Year: 2013, Volume and Issue: 38(4), P. 633 - 643

Published: April 1, 2013

Language: Английский

---

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Cell, Journal Year: 2011, Volume and Issue: 146(5), P. 772 - 784

Published: Aug. 27, 2011

Language: Английский

---

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Science, Journal Year: 2013, Volume and Issue: 342(6155)

Published: Oct. 10, 2013

Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation also adapt to changing environmental conditions, in which nutrients oxygen may be limiting. An emerging theme immunology is that reprogramming lymphocyte activation are intricately linked. However, why T cells adopt specific programs impact these have on function and, ultimately, immunological outcome remain unclear. Research tumor metabolism has provided valuable insight into pathways important for influence metabolites themselves signal transduction epigenetic programming. In this Review, we highlight concepts regarding proliferating discuss their potential fate function.

Language: Английский

---

Metabolic Regulation of T Lymphocytes

Annual Review of Immunology, Journal Year: 2013, Volume and Issue: 31(1), P. 259 - 283

Published: Jan. 9, 2013

T cell activation leads to dramatic shifts in metabolism protect against pathogens and orchestrate the action of other immune cells. Quiescent cells require predominantly ATP-generating processes, whereas proliferating effector high metabolic flux through growth-promoting pathways. Further, functionally distinct subsets energetic biosynthetic pathways support their specific functional needs. Pathways that control function are intimately linked, changes at both system levels have been shown enhance or suppress functions. As a result these findings, is now appreciated as key regulator specification fate. This review discusses role cellular development, activation, differentiation, highlight clinical relevance opportunities for therapeutic interventions may be used disrupt pathogenesis.

Language: Английский

---

Metabolism of inflammation limited by AMPK and pseudo-starvation

Nature, Journal Year: 2013, Volume and Issue: 493(7432), P. 346 - 355

Published: Jan. 15, 2013

Language: Английский

---