History and progress of hypotheses and clinical trials for Alzheimer’s disease DOI Creative Commons
Peipei Liu, Yi Xie, Xiao‐Yan Meng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Aug. 23, 2019

Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive memory loss along with neuropsychiatric symptoms and decline in activities of daily life. Its main pathological features are cerebral atrophy, amyloid plaques, neurofibrillary tangles the brains patients. There various descriptive hypotheses regarding causes AD, including cholinergic hypothesis, tau propagation mitochondrial cascade calcium homeostasis neurovascular inflammatory metal ion lymphatic system hypothesis. However, ultimate etiology AD remains obscure. In this review, we discuss related clinical trials. Wealthy puzzles lessons have made it possible to develop explanatory theories identify potential strategies for therapeutic interventions AD. The combination hypometabolism autophagy deficiency likely be causative factor We further propose that fluoxetine, selective serotonin reuptake inhibitor, has treat

Language: Английский

Perivascular spaces in the brain: anatomy, physiology and pathology DOI
Joanna M. Wardlaw, Helene Benveniste,

Maiken Nedergaard

et al.

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 16(3), P. 137 - 153

Published: Feb. 24, 2020

Language: Английский

Citations

610
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid DOI
Ji Hoon Ahn, Hyunsoo Cho, Junhee Kim

et al.

Nature, Journal Year: 2019, Volume and Issue: 572(7767), P. 62 - 66

Published: July 24, 2019

Language: Английский

Citations

608
Revisiting the Mechanisms of CNS Immune Privilege DOI
Antoine Louveau, Tajie H. Harris, Jonathan Kipnis

et al.

Trends in Immunology, Journal Year: 2015, Volume and Issue: 36(10), P. 569 - 577

Published: Oct. 1, 2015

Language: Английский

Citations

595
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity DOI
Natalie L. Trevaskis, Lisa M. Kaminskas, Christopher J. H. Porter

et al.

Nature Reviews Drug Discovery, Journal Year: 2015, Volume and Issue: 14(11), P. 781 - 803

Published: Oct. 16, 2015

Language: Английский

Citations

575
History and progress of hypotheses and clinical trials for Alzheimer’s disease DOI Creative Commons
Peipei Liu, Yi Xie, Xiao‐Yan Meng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Aug. 23, 2019

Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive memory loss along with neuropsychiatric symptoms and decline in activities of daily life. Its main pathological features are cerebral atrophy, amyloid plaques, neurofibrillary tangles the brains patients. There various descriptive hypotheses regarding causes AD, including cholinergic hypothesis, tau propagation mitochondrial cascade calcium homeostasis neurovascular inflammatory metal ion lymphatic system hypothesis. However, ultimate etiology AD remains obscure. In this review, we discuss related clinical trials. Wealthy puzzles lessons have made it possible to develop explanatory theories identify potential strategies for therapeutic interventions AD. The combination hypometabolism autophagy deficiency likely be causative factor We further propose that fluoxetine, selective serotonin reuptake inhibitor, has treat

Language: Английский

Citations

571