Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11

Published: Feb. 2, 2021

Tumor-specific CD8+T cells are exposed to persistent antigenic stimulation which induces a dysfunctional state called "exhaustion." Though functioning limit damage caused by immune response, T cell exhaustion leads attenuated effector function whereby cytotoxic fail control tumor progression in the late stage. This pathway is dynamic process from activation "progenitor exhaustion" through "terminally with distinct properties. With rapid development of immunotherapy via enhancing function, new studies dissecting mechanisms and identifying specific biomarkers differentiation during exhaustion. Further, although checkpoint inhibitors (ICIs) have achieved great success clinical practice, most patients still show limited efficacy ICIs. The expansion progenitor exhausted explained ICIs while depletion pool transient terminally accounted for failure monotherapy context exorbitant burden. Thus, combination strategies urgent be utilized based on reduction burden or pool. In this review, we aim introduce concept homeostasis activated status microenvironment, present recent findings implications therapy.

Language: Английский

---

Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 583 - 609

Published: Feb. 27, 2021

Understanding tumor immune microenvironments is critical for identifying modifiers of cancer progression and developing immunotherapies. Recent applications single-cell RNA sequencing (scRNA-seq) in dissecting have brought important insights into the biology tumor-infiltrating cells, including their heterogeneity, dynamics, potential roles both disease response to checkpoint inhibitors other This review focuses on advances knowledge acquired from scRNA-seq studies across multiple types human tumors, with a particular emphasis study phenotypic plasticity lineage dynamics cells environment. We also discuss several imminent questions emerging observations solutions horizon.

Language: Английский

---

A reservoir of stem-like CD8 ⁺ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response

Science Immunology, Journal Year: 2021, Volume and Issue: 6(64)

Published: Sept. 2, 2021

Tumor-specific CD8 + T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those tumors.

Language: Английский

---

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

Nature, Journal Year: 2021, Volume and Issue: 597(7875), P. 279 - 284

Published: Sept. 1, 2021

Language: Английский

---

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes

Cell, Journal Year: 2023, Volume and Issue: 186(6), P. 1127 - 1143.e18

Published: March 1, 2023

CD8

Language: Английский

---