
Cell, Journal Year: 2023, Volume and Issue: 186(6), P. 1127 - 1143.e18
Published: March 1, 2023
CD8
Language: Английский
Cell, Journal Year: 2023, Volume and Issue: 186(6), P. 1127 - 1143.e18
Published: March 1, 2023
CD8
Language: Английский
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11
Published: Feb. 2, 2021
Tumor-specific CD8+T cells are exposed to persistent antigenic stimulation which induces a dysfunctional state called "exhaustion." Though functioning limit damage caused by immune response, T cell exhaustion leads attenuated effector function whereby cytotoxic fail control tumor progression in the late stage. This pathway is dynamic process from activation "progenitor exhaustion" through "terminally with distinct properties. With rapid development of immunotherapy via enhancing function, new studies dissecting mechanisms and identifying specific biomarkers differentiation during exhaustion. Further, although checkpoint inhibitors (ICIs) have achieved great success clinical practice, most patients still show limited efficacy ICIs. The expansion progenitor exhausted explained ICIs while depletion pool transient terminally accounted for failure monotherapy context exorbitant burden. Thus, combination strategies urgent be utilized based on reduction burden or pool. In this review, we aim introduce concept homeostasis activated status microenvironment, present recent findings implications therapy.
Language: Английский
Citations
264Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 583 - 609
Published: Feb. 27, 2021
Understanding tumor immune microenvironments is critical for identifying modifiers of cancer progression and developing immunotherapies. Recent applications single-cell RNA sequencing (scRNA-seq) in dissecting have brought important insights into the biology tumor-infiltrating cells, including their heterogeneity, dynamics, potential roles both disease response to checkpoint inhibitors other This review focuses on advances knowledge acquired from scRNA-seq studies across multiple types human tumors, with a particular emphasis study phenotypic plasticity lineage dynamics cells environment. We also discuss several imminent questions emerging observations solutions horizon.
Language: Английский
Citations
254Science Immunology, Journal Year: 2021, Volume and Issue: 6(64)
Published: Sept. 2, 2021
Tumor-specific CD8 + T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those tumors.
Language: Английский
Citations
247Nature, Journal Year: 2021, Volume and Issue: 597(7875), P. 279 - 284
Published: Sept. 1, 2021
Language: Английский
Citations
243Cell, Journal Year: 2023, Volume and Issue: 186(6), P. 1127 - 1143.e18
Published: March 1, 2023
CD8
Language: Английский
Citations
229