Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective

Bone, Journal Year: 2024, Volume and Issue: 189, P. 117255 - 117255

Published: Sept. 14, 2024

Language: Английский

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Therapy-Induced Senescence: Novel Approaches for Markers Identification

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8448 - 8448

Published: Aug. 2, 2024

Therapy-induced senescence (TIS) represents a major cellular response to anticancer treatments. Both malignant and non-malignant cells in the tumor microenvironment undergo TIS may be harmful for cancer patients since develop senescence-associated secretory phenotype (SASP) that can sustain growth. The SASP also modulates anti-tumor immunity, although immune populations involved final results appear context-dependent. In addition, senescent are able evade growth arrest resume proliferation, likely contributing relapse. So, research data suggest induction negatively affects therapy outcomes patients. line with this, new interventions aimed at removal of or reprogramming their SASP, called senotherapy, have become attractive therapeutic options. To date, lack reliable, cost-effective, easy-to-use biomarkers hinders application recent anti-senescence approaches clinic. Hence, identification detection non-neoplastic is high priority research. this review article, we describe current knowledge about TIS, outline critical gaps our knowledge, address advances novel discovery biomarkers.

Language: Английский

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Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 10, 2024

Fuchs Endothelial Corneal Dystrophy (FECD) is an aging disorder characterized by expedited loss of corneal endothelial cells (CEnCs) and heightened DNA damage compared to normal CEnCs. We previously established that ultraviolet-A (UVA) light causes leads FECD phenotype in a non-genetic mouse model. Here, we demonstrate acute treatment with chemical stressor, menadione, or physiological stressors, UVA, catechol estrogen (4-OHE

Language: Английский

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Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Oxidative stress results from an imbalance between the production and neutralization of reactive oxygen species. It induces oxidative damage to cellular components including proteins, lipids, nucleic acids, membranes, therefore intrinsically linking aging‐related diseases such as cancer, cardiovascular disease, neurological disorders. Emerging evidence suggests that may promote tumor development by influencing various aspects senescence, its onset, pro‐inflammatory secretion, alteration function structure. Modulating target senescence offers a novel strategy for cancer prevention treatment. However, thorough grasp specific mechanisms at play is lacking. This review will present association their regulatory role in progression treatment, with emphasis on senescence‐associated secretory phenotype, immunosenescence therapy‐induced senescence. Current agents strategies remove side effects via killing senescent cells or modulating improve antitumor efficacy be summarized. help readers better understand complex relationship also provide basis further research this area.

Language: Английский

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Development and experimental validation of a senescence-related long non-coding RNA signature for prognostic prediction and immune microenvironment characterization in gastric cancer patients

Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(6), P. 2413 - 2436

Published: Dec. 1, 2024

Cellular senescence is considered a new marker of cancer. It has been suggested that long non-coding RNA (lncRNA) can be used to predict the prognosis cancers. However, it remains seen whether lncRNAs associated with cellular gastric cancer (GC). The present study aimed develop novel senescence-related lncRNA signature (SenLncSig) GC prognosis. SenLncSig model holds promise for enhancing patient stratification, enabling more precise prognostic predictions and facilitating immunotherapy strategies. Senescence-associated were identified from expression profiles in Cancer Genome Atlas (TCGA) database through construction co-expression network linking genes lncRNAs. A (334 patients TCGA-STAD data set), comprising lncRNAs, was developed univariate multivariate Cox proportional hazards regression analyses. By using median risk score, categorized into high- low-risk groups. Kaplan-Meier analysis gene set enrichment conducted, immune infiltration, tumor mutation burden (TMB), pharmacological treatments compared between We an independent cohort (an external 30 pairs non-tumor tissues patients) three cell lines conduct quantitative reverse-transcription polymerase chain reaction (qRT-PCR) validate results. established SenLncSig, following five senescence-associated lncRNAs; AP000695.2, LINC02381, AC005586.1, AP003392.1, AP001528.2. According high-risk scores poor overall survival (multivariate hazard ratio: 1.498, 95% confidence interval: 1.294-1.735; P<0.001). time-dependent receiver operating characteristic curve indicated performed (area under curve: 0.711). nomogram incorporating age, gender, grade, stage, T M N score estimate 1-year, 3-year, 5-year rates. Further, according results analysis, high TMB group had worst Interestingly, stronger infiltration regulatory cells (P<0.001) M2 macrophage (P<0.001), as well higher dysfunction exclusion than group. These might explain why worse Finally, qRT-PCR validation revealed AP000695.2 AP003392.1 levels significantly normal human epithelial line, whereas opposite pattern found LINC02381. development provided potential tool improving offered preliminary insights predicting efficacy immunotherapy.

Language: Английский

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