Glymphatic system impairment in normal tension glaucoma evaluated by diffusion tensor image analysis along the perivascular space

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149450 - 149450

Published: Jan. 1, 2025

Language: Английский

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Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(1), P. 36 - 36

Published: Jan. 15, 2025

Purpose: Changes associated with Alzheimer's disease (AD) may have measurable effects on the retina, which facilitate early detection due to eye's accessibility. Retinal pathology and regulation of serine racemase (SR) were investigated in retinas APP(SW)/PS1(∆E9) mice. Methods: SR content D-serine aqueous humor analyzed. The structure function retina assessed. Additionally, primary Müller cell cultures was investigated. Results: levels significantly higher 18- 24-month-old male APP/PS1 mice, whereas lower mice compared wild-type (WT) Neither Aβ nor 17β-estradiol increased SR, but combination both did cultures. In contrast, Srr mRNA At 8 months age, began display reduced b-wave amplitude scotopic photopic electroretinography (ERG) recordings, unlike female Although retinal layer thickness not differ from WT there overt apoptosis inner outer nuclear layers retinas. Conclusions: age- sex-specific is correlated an AD retina. Because time window for alteration occurs after photoreceptor dysfunction retinas, it has limited value as a biomarker be useful topographic staging severity monitoring drug interventions eye or central nervous system.

Language: Английский

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Retinal and Optic Nerve Lesions Correspond to Amyloid in Autosomal Dominant Alzheimer's Disease

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Autosomal dominant Alzheimer’s disease (ADAD) is a rare form of (AD) in which the biology can be explored during presymptomatic phase illness. The retina an outgrowth central nervous system and therefore provides opportunity for direct observation neural tissue its vasculature life. Retinal thinning measured vivo has been previously described persons carrying ADAD mutations through fundoscopy but pathologic correlates have not reported. We describe retinal lesions detected using patient homozygous A431E mutation PSEN1 pathological correlates. seen with life corresponded to intraretinal prelaminar optic nerve head amyloid β 42 -protein that were surrounded by perivascular anti-11A50-B10-Aβ 40 gliosis. then performed cross-sectional, observational study forty-one Latinos three cohorts consisting (1) causing mutations, (2) at 50% risk for, testing negative (3) elderly subjects at-risk ADAD. Clinical exam demonstrated novel, yellow, Cohort 1 absence drusen. Fifty-six percent had >10 compared 0% 25% Cohorts 2 3, respectively ( P < 0.04). There some controversy as detectability Aβ AD our findings verify presence intraretinal, prelaminar, amyloidosis detectable subset patients.

Language: Английский

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Non-Invasive Retinal Biomarkers for Early Diagnosis of Alzheimer’s Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 283 - 283

Published: Jan. 24, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain associated with ageing and most prevalent form dementia, affecting an estimated 55 million people worldwide, projections suggesting this number will exceed 150 by 2050. With its increasing prevalence, AD represents significant global health challenge potentially serious social economic consequences. Diagnosing particularly challenging as it requires timely recognition. Currently, there no effective therapy for AD; however, certain medications may help slow progression. Existing diagnostic methods such magnetic resonance imaging (MRI), computed tomography (CT), positron emission (PET), biomarker analysis in cerebrospinal fluid tend to be expensive invasive, making them impractical widespread use. Consequently, research into non-invasive biomarkers that enable early detection screening crucial area contemporary clinical investigation. One promising approach diagnosis retinal imaging. As extension central nervous system, retina offers distinctive opportunity structure function assessment. Considering their shared embryological origins vascular immunological similarities between eye brain, alterations indicate pathological changes including those specifically related AD. Studies suggest structural retina, within neuronal network blood vessels, act markers cerebral caused These have potential diagnosis. Since typically diagnosed only after loss has occurred, identifying could intervention prevent Non-invasive techniques, optical coherence (OCT) OCT angiography, provide accessible linked This review article focuses on Investigating connections processes significantly enhance diagnosis, monitoring, treatment AD, paving way new therapeutic approaches.

Language: Английский

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Shared Mechanisms in Neuromyelitis Optica Spectrum Disorder and Spaceflight-Associated Neuro-Ocular Syndrome: Insights into Central Nervous System Fluid Dynamics, Glymphatic Function, and Astrocyte Dysregulation

Life Sciences in Space Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?

Eye, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Language: Английский

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Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

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The brain–eye connection: More than just action potentials

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(11)

Published: Sept. 27, 2024

In this issue of the Journal Experimental Medicine, Cao et al. (https://doi.org/10.1084/jem.20240386) demonstrate that connection between eye and brain goes beyond impulses carried by optic nerve in Alzheimer’s disease (AD), influx toxic Aβ from to retina underlies AD-induced retinal degeneration.

Language: Английский

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