No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis

The Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 222(3)

Published: Jan. 22, 2025

Bernaleau et al. (https://doi.org/10.1084/jem.20240825) show that CCDC134 located in the ER is required for TLR biogenesis by controlling N-glycosylation, folding, and stabilization of chaperone Gp96.

Language: Английский

Glucose-regulated Protein 94 (Grp94/gp96) in Viral Pathogenesis: Insights Into Its Role and Therapeutic Potentials

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 292, P. 117713 - 117713

Published: April 30, 2025

Glucose-regulated protein 94 (Grp94/gp96) is endoplasmic reticulum (ER) resident form of the 90 kDa heat shock (Hsp90) that responsible for folding, maturation and stabilization more than 400 client proteins. Grp94 has been implicated various diseases including metastatic cancer, primary open-angle glaucoma, infectious diseases. In fact, plays critical roles in different stages viral infection cycle. It chaperones receptor proteins glycoproteins are necessary entry replication. Beyond its role homeostasis, modulates host cellular processes such as apoptosis immune responses, which often exploited by viruses to sustain infection. This work provides an overview pathogenesis across involvement modulation with development Grp94-selective inhibitors their potential anti-viral therapeutics.

Language: Английский

Toll-like receptor-4 in the fish immune system

Developmental & Comparative Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 105400 - 105400

Published: June 1, 2025

Language: Английский