Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans DOI
Leslie Naesens, Steven Callens, Tessa Kerre

et al.

European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(5)

Published: May 1, 2025

ABSTRACT The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and trigger type I interferon (IFN‐I) responses, which are crucial for antiviral defense. NA pattern recognition receptors RNA or DNA within various cellular compartments, initiating signaling pathways. However, inherited deficiencies in these sensing mechanisms can result increased susceptibility severe infections. This review explores key genetic mutations affecting IFN‐I pathways that predispose individuals life‐threatening diseases, including herpesviruses, respiratory viruses, enteroviruses, arboviruses, vaccine‐strain disseminated diseases. identification of monogenic defects afflicted by infections, along with the observed incomplete penetrance mutations, highlight intricate interplay host's intrinsic, innate, adaptive response invading pathogens. These insights into molecular basis immunity not only underscore clinical challenges associated but also offers opportunity personalized treatment strategies, screening, tailored vaccination protocols, targeted therapies.

Language: Английский

Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans DOI
Leslie Naesens, Steven Callens, Tessa Kerre

et al.

European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(5)

Published: May 1, 2025

ABSTRACT The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and trigger type I interferon (IFN‐I) responses, which are crucial for antiviral defense. NA pattern recognition receptors RNA or DNA within various cellular compartments, initiating signaling pathways. However, inherited deficiencies in these sensing mechanisms can result increased susceptibility severe infections. This review explores key genetic mutations affecting IFN‐I pathways that predispose individuals life‐threatening diseases, including herpesviruses, respiratory viruses, enteroviruses, arboviruses, vaccine‐strain disseminated diseases. identification of monogenic defects afflicted by infections, along with the observed incomplete penetrance mutations, highlight intricate interplay host's intrinsic, innate, adaptive response invading pathogens. These insights into molecular basis immunity not only underscore clinical challenges associated but also offers opportunity personalized treatment strategies, screening, tailored vaccination protocols, targeted therapies.

Language: Английский

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