Characterizing PTSD Using Electrophysiology: Towards A Precision Medicine Approach
Clinical EEG and Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Objective.
Resting-state
EEG
measures
have
shown
potential
in
distinguishing
individuals
with
PTSD
from
healthy
controls.
ERP
components
such
as
N2,
P3,
and
late
positive
been
consistently
linked
to
cognitive
abnormalities
PTSD,
especially
tasks
involving
emotional
or
trauma-related
stimuli.
However,
meta-analyses
reported
inconsistent
findings.
The
understanding
of
biomarkers
that
can
classify
the
varied
symptoms
remains
limited.
This
study
aimed
develop
a
concise
set
electrophysiological
biomarkers,
using
neutral
tasks,
could
be
applied
across
psychiatric
conditions,
identify
associated
anxiety
depression
dimensions
PTSD.
Approach.
Continuous
simultaneous
recordings
electrocardiogram
(ECG)
were
obtained
veterans
(n
=
29)
controls
62)
during
computerized
tasks.
EEG,
ERP,
heart
rate
evaluated
terms
their
ability
discriminate
between
groups
correlate
psychological
measures.
Results.
cohort
exhibited
faster
alpha
oscillations,
reduced
power,
flatter
power
spectrum.
Furthermore,
stronger
reduction
was
higher
trait
anxiety,
while
slope
related
more
severe
In
visual
memory
sustained
attention,
demonstrated
delayed
exaggerated
early
components,
along
attenuated
LPP
amplitudes.
three
revealed
distinct
complementary
signatures
Significance.
Multimodal
individualized
based
on
ERPs,
ECG
show
promise
objective
tools
for
assessing
mood
disturbances
within
Language: Английский
PTSD-related differences in neural connectivity among female trauma survivors
Biological Psychiatry Global Open Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100491 - 100491
Published: March 1, 2025
Language: Английский
A systematic review of aperiodic neural activity in clinical investigations
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
Abstract
In
the
study
of
neuro-electrophysiological
recordings,
aperiodic
neural
activity
–
with
no
characteristic
frequency
has
increasingly
become
a
common
feature
study.
This
interest
rapidly
extended
to
clinical
work,
many
reports
investigating
from
patients
broad
range
disorders.
work
typically
seeks
evaluate
as
putative
biomarker
relating
diagnosis
or
treatment
response,
and/or
potential
marker
underlying
physiological
activity.
There
is
thus
far
clear
consensus
on
if
and
how
relates
disorders,
nor
best
practices
for
it
in
research.
To
address
this,
this
systematic
literature
review,
following
PRISMA
guidelines,
examines
electrophysiological
recordings
human
psychiatric
neurological
finding
143
across
35
distinct
Reports
within
disorders
are
summarized
current
findings
examine
what
can
be
learned
pertains
analysis,
interpretations,
overall
utility
investigations.
Aperiodic
commonly
reported
relate
diagnoses,
31
reporting
significant
effect
diagnostic
related
studies.
However,
there
variation
consistency
results
heterogeneity
patient
groups,
disease
etiologies,
status
arising
themes
different
Overall,
variability
results,
potentially
confounding
covariates,
limitations
understanding
suggests
further
needed
before
established
pathological
physiology.
Finally,
series
recommendations
proposed,
based
findings,
limitations,
key
discussion
topics
assist
guiding
productive
future
studying
Project
Repository
The
project
repository
contains
code
&
data
project:
https://github.com/TomDonoghue/AperiodicClinical
Language: Английский
Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis
Depression and Anxiety,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
The
heterogeneity
of
posttraumatic
stress
disorder
(PTSD)
is
an
obstacle
to
both
understanding
and
therapy,
this
has
prompted
a
search
for
internally
homogeneous
neuroradiological
subgroups
within
the
broad
clinical
diagnosis.
We
set
out
do
using
individual
differential
structural
covariance
network
(IDSCN).
constructed
cortical
thickness-based
IDSCN
T1-weighted
images
89
individuals
with
PTSD
(mean
age
42.8
years,
60
female)
demographically
matched
trauma-exposed
non-PTSD
(TENP)
controls
43.1
63
female).
metric
quantifies
how
edges
in
patient
differ
from
those
controls.
examined
diversity
variation
among
subtypes
hierarchical
clustering
analysis.
patients
exhibited
notable
distinct
but
mainly
affecting
three
networks:
default
mode,
ventral
attention,
sensorimotor.
These
changes
predicted
symptom
severity.
identified
two
neuroanatomical
subtypes:
one
higher
severity
showed
lower
frontal
cortex
between
frontal,
parietal,
occipital
cortex-regions
that
are
functionally
implicated
selective
response
selection,
learning
tasks.
Thus,
deviations
large-scale
networks
common
fall
into
subtypes.
This
work
sheds
light
on
neurobiological
mechanisms
underlying
may
aid
personalized
diagnosis
therapeutic
interventions.
Language: Английский
Construction and Validation of a New BrainView qEEG Discriminant Database
Annie TL Young,
No information about this author
Slav Danev,
No information about this author
Jonathan R. T. Lakey
No information about this author
et al.
Acta Scientific Neurology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 25 - 51
Published: June 1, 2024
A
normative
quantitative
electroencephalogram
(qEEG)
database
is
vital
for
assessing
brain
disorders.However,
constructing
qEEG
databases
research
and
clinical
applications
has
posed
challenges
over
the
past
61
years,
due
to
defining
'normal'
population
lack
of
standardized
procedures
EEG
data.This
study
aims
build
a
new
BrainView
discriminant
that
meets
strict
data
criteria
derived
from
field's
milestones,
using
method
similar
used
construct
database.It
follows
key
procedures:
collection
preprocessing,
feature
extraction
selection,
as
well
classification
validation.BrainView
comprises
28,283
subjects
(7,798
healthy
subjects)
eyesopen
eyes-closed
conditions,
spanning
ages
4
85
years.Developed
patient
data,
BrainView's
function
identifies
patient's
likelihood
belonging
specific
group,
aiding
in
precise
diagnosis.The
goal
establish
gold
standard
diagnosis
prognosis
various
disorders,
enabling
use
practice.
Language: Английский
Potential Neurophysiological Markers of Combat-Related Post-Traumatic Stress Disorder: A Cross-Sectional Diagnostic Study
Consortium Psychiatricum,
Journal Year:
2024,
Volume and Issue:
5(2), P. 31 - 44
Published: June 28, 2024
BACKGROUND:
Studies
suggest
that
the
components
of
brain-evoked
potentials
(EPs)
may
serve
as
biomarkers
post-traumatic
stress
disorder
(PTSD)
caused
by
participation
in
combat
operations;
however,
to
date,
research
remains
fragmented,
with
no
studies
have
attempted
combine
different
paradigms.
In
addition,
mismatch
negativity
component
has
not
been
studied
a
Russian
sample
veterans
PTSD.
AIM:
To
identify
objective
neurophysiological
markers
combat-related
PTSD
using
method
auditory-evoked
active
and
passive
listening
METHODS:
The
study
included
recording
auditory
EPs
an
oddball
paradigm
three
settings:
1)
directed
attention
stimuli,
2)
while
viewing
neutral
video
sequence,
3)
sequence
associated
traumatic
event.
Combatants
diagnosed
(18
people)
were
compared
mentally
healthy
civilian
volunteers
(22
people).
RESULTS:
An
increase
latency
period
early
EP
(N100
P200),
amplitude
P200
deviant
stimulus,
decrease
standard
one
established
group.
There
significant
differences
parameters
P300
component.
characteristics
revealed:
phenomenon
amplitude,
both
when
shown
event
sequence.
A
binary
logistic
regression
model
constructed
selected
showed
identified
can
potentially
be
considered
diagnostic
combatants,
classification
accuracy
stood
at
87%
(sensitivity
—
81%,
specificity
91%).
CONCLUSION:
Potential
are
following:
stimuli
during
attention.
Language: Английский
A Review on Machine Learning Models for Breathing Pattern Analysis of Soldiers
P. Kaleeswari,
No information about this author
R. Ramalakshmi,
No information about this author
Arunprasath Thiyagarajan
No information about this author
et al.
Published: Dec. 14, 2023
Since
2001,
the
U.S.
military
has
sent
2.7
million
people
to
support
missions
in
Afghanistan
and
Asia.
The
experience
of
land-based
employees
is
increased
by
exposure
additional
inhalational
exposures
particulate
matter
from
a
variety
sources.
For
purpose
preventing
significant
loss
nation
individual
soldier,
post-traumatic
stress
disorder
(PTSD)
must
be
identified.
Breathing
pattern
analysis
key
method
for
detecting
PTSD,
various
studies
have
used
machine
learning
techniques
this
purpose.
This
survey
examines
multiple
ML
models
determine
soldiers'
breathing
patterns
distinct
works.
overview
discusses
several
strategies
over
past
few
decades
conducting
extensive
research.
Military
personnel'
are
analyzed
using
datasets,
statistical
factors,
methodologies.
effectiveness
algorithms
compared
qualitative
as
well
quantitative
approaches.
potential
future
study
areas
with
major
challenges
discussed
reach
conclusion.
Language: Английский