Biomaterial-based strategies: a new era in spinal cord injury treatment

Neural Regeneration Research, Journal Year: 2025, Volume and Issue: 20(12), P. 3476 - 3500

Published: Jan. 13, 2025

Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently. Spinal is associated with a complex molecular cellular microenvironment. This complexity has prompted researchers to elucidate underlying pathophysiological mechanisms changes identify effective treatment strategies. Traditional approaches for repair include surgery, oral or intravenous medications, administration neurotrophic factors; however, efficacy these remains inconclusive, serious adverse reactions continue be concern. With advancements in tissue engineering regenerative medicine, emerging strategies now involve nanoparticle-based nanodelivery systems, scaffolds, functional techniques that incorporate biomaterials, bioengineering, stem cell, growth factors as well three-dimensional bioprinting. Ideal biomaterial scaffolds should not only provide structural support neuron migration, adhesion, proliferation, differentiation but also mimic mechanical properties natural tissue. Additionally, facilitate axon neurogenesis by offering adjustable topography range physical biochemical cues. The three-dimensionally interconnected porous structure appropriate physicochemical enabled biomimetic printing technology can maximize potential biomaterials used treating injury. Therefore, correct selection application coupled successful clinical translation, represent promising objectives enhance review elucidates key occurrence regeneration post-injury, including neuroinflammation, oxidative stress, regeneration, angiogenesis. briefly discusses critical role systems injured cord, highlighting influence nanoparticles affect delivery efficiency. Finally, this highlights It various types their integrations cells factors, optimization scaffold design.

Language: Английский

---

Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101639 - 101639

Published: March 4, 2025

Motor function recovery after complete spinal cord injury remained as a challenge in medical field, while one of the key approaches is promoting local microenvironments. In this research, we performed conjugated therapy by transplantation neural stem cell (NSC) scaffolds and umbilical mesenchymal derived exosomes (ucMSC-exos) for treatment transactional (SCI). We first demonstrated anti-inflammatory effects ucMSC-exos vitro found that could regulate microglia polarization from M1 to M2, an phenotype. Besides, also promoted NSC proliferation differentiation during culturing. On other hand, core-shell hydrogel microfibers were used both small large SCI defects. The carry amounts NSCs core portion shell highly permeable nutrient metabolite transportation. vivo experiments, decreased inflammatory cytokines at lesion sites, gave rise more neurons angiogenesis, thus comprehensively improved microenvironment compared with only. These beneficial results accordance those experiments further led better locomotor recovery. summary, research has make potential tool repair.

Language: Английский

---

Benzeneboronic acid-modified hyaluronic acid hydrogel enhances the differentiation of dorsal root ganglion stem cells in a three-dimensional environment

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142786 - 142786

Published: April 1, 2025

Language: Английский

---

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

---

Bioinspired fibrous scaffolds with hierarchical orientations for enhanced spinal cord injury repair

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157969 - 157969

Published: Nov. 1, 2024

Language: Английский

---

Engineered Tools to Advance Cell Transplantation in the Nervous System Towards a Clinical Reality

Current Transplantation Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

---