BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 28, 2024
Language: Английский
BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 28, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 12, 2025
Language: Английский
Citations
0ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1085 - 1111
Published: Feb. 19, 2025
Language: Английский
Citations
0BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 20, 2025
Antibiotic resistance is a growing global threat due to antibiotic overuse and limited treatment options. Multidrug-resistant bacteria, like Staphylococcus aureus Escherichia coli, increase infection complexity mortality. This study explores nanocomposite films of ZIF-8 nanoparticles Doxycycline (Dox) enhance antibacterial efficacy. In this study, composed chitosan (CS) polyethylene glycol (PEG), incorporating zeolitic imidazolate framework-8 (ZIF-8) DOX, were developed. These characterized by their morphological, mechanical, antibacterial, drug-release properties. Antibacterial efficacy was evaluated using disk diffusion, broth microdilution, checkerboard assay methods determine MICs potential synergistic effects. The demonstrated flexibility, semi-transparency, yellowish-brown hue, with containing being thicker (79 ± 0.2 μm) than those without (54 0.5 μm). tensile strength enhanced the incorporation ZIF-8, peaking at 53.12 MPa for CS-PEG-G-10% DOX-4% film. XRD analysis confirmed crystallinity distinct peaks observed each material. drug release studies revealed an initial burst followed sustained release, higher rates in acidic environments compared neutral alkaline media. film significantly activity, achieving lowest MIC values, particularly against S. (22.5 mm inhibition zone) E. coli (14 zone). Additionally, notable effect between DOX FICI values below 0.5. exhibits optimal properties, positioning it as strong candidate developing effective treatments multidrug-resistant pathogens.
Language: Английский
Citations
0Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
0Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107558 - 107558
Published: April 1, 2025
Language: Английский
Citations
0IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
Antimicrobial resistance has created an urgent need for innovative therapeutic strategies beyond conventional antibiotics. Nanotechnology offers a groundbreaking approach to addressing this challenge by providing versatile tools targeted antimicrobial action. This chapter explores the application of nanomaterials in combating multidrug-resistant pathogens. Emphasis is placed on their mechanisms action, such as biofilm disruption, precision drug delivery, and enhancement efficacy. also discusses recent advancements nano-engineered systems pathogen targeting, well role overcoming mechanisms. By shedding light potential limitations nanotechnology therapy, aims present transformative ongoing battle against superbugs.
Language: Английский
Citations
0BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 28, 2024
Language: Английский
Citations
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