Innovations in Core–Shell Nanoparticles: Advancing Drug Delivery Solutions and Precision Medicine

OMICS A Journal of Integrative Biology, Journal Year: 2025, Volume and Issue: 29(3), P. 73 - 86

Published: Feb. 21, 2025

Drug delivery innovation is an important pillar of systems pharmacology wherein nanotechnology offers significant prospects. This expert review examines and unpacks how core-shell nanoparticles (NPs) could revolutionize drug play a key role in advancing personalized precision medicine. Core-shell NPs have gained attention as flexible tools for due to their distinct structure, which features core material enclosed by protective shell. setup multiple benefits, such effective encapsulation, shielding the from degradation, allowing controlled release. Accordingly, serves safe storage area while shell manages release speed, providing added stability supporting sustained delivery. By enabling targeted release, this mechanism can help improve treatment outcomes reduce side effects. Various materials, including polymers, lipids, inorganic substances create these NPs. Biodegradable poly(lactic-co-glycolic acid) poly(lactic acid), are popular choices because they offer adjustable degradation rates, further control released. These materials be tailored better loading, compatibility with host organism, specific chemical properties suit different therapeutic needs. Research into has been many areas, highlighting potential innovations. The not just possibility but promising reality that significantly advance field personalized/precision

Language: Английский

Synthesis and Characterization of Novel Luminol‐Based Carbon Dots for Dual‐Mode Chemiluminescence and Fluorescence Detection of Nitrite in Water Samples

Luminescence, Journal Year: 2025, Volume and Issue: 40(4)

Published: April 1, 2025

ABSTRACT A green hydrothermal method was used to synthesize luminol‐based carbon dots (Lu‐CDs) for chemiluminescence (CL) and fluorescence (FL) detection of nitrite ions in water samples. Lu‐CDs were characterized by using different techniques. The morphology indicates a spherical shape an amorphous crystalline structure. reversed flow injection analysis (rFIA) CL developed based on the Lu‐CDs‐N‐bromosuccinimide‐NaOH system, where signal quenched ions. For FL analysis, exhibited blue at 425 nm (quantum yield: 56.42%) upon 350 excitation, which pH 6.5. Reaction conditions parameters optimized both methods. methods showed linearity concentrations 1.5–20.0 μg mL −1 0.85–50.0 , with limits 0.75 0.55 respectively. Applicability validated through tap groundwater showing agreement standard spectrophotometric (Student's t ‐test, F ‐test). greenness evaluated AGREE GAPI tools, while their applicability assessed BAGI tool, highlighting eco‐friendly reliable nature water.

Language: Английский