The association between HIV-1 Tat and Vif amino acid sequence variation, inflammation and Trp-Kyn metabolism: an exploratory investigation DOI Creative Commons
Monray E. Williams,

Levanco K. Asia,

Jeremie Zander Lindeque

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 9, 2024

Language: Английский

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management DOI
Ronald J. Ellis, María J. Marquine, Marcus Kaul

et al.

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(11), P. 668 - 687

Published: Oct. 10, 2023

Language: Английский

Citations

32
A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment DOI Creative Commons

Levanco K. Asia,

Esmé Jansen van Vuren, Jeremie Zander Lindeque

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 23, 2024

Abstract HIV infection compromises both the peripheral and central immune systems due to its pathogenic neuropathogenic features. The mechanisms driving HIV-1 pathogenesis neuropathogenesis involve a series of events, including metabolic dysregulation. Furthermore, HIV-subtype-specific variations, particularly alterations in amino acid sequences key viral proteins, are known influence severity clinical outcomes people living with HIV. However, impact sequence variations specific such as Viral protein R (Vpr), on metabolites within Tryptophan (Trp)-kynurenine (Kyn) pathway remains unclear. Our research aimed explore relationship between Vpr (specifically at positions 22, 41, 45, 55, these have been previously linked neurocognitive function) Trp-Kyn metabolites. Additionally, we sought clarify biology variation by examining link metabolism inflammation, mechanism. In this preliminary study, analyzed unique cohort thirty-two ( n = 32) South African cART naïve We employed Sanger sequencing ascertain blood-derived targeted LC-MS/MS metabolomics platform assess metabolites, Trp, Kyn, kynurenic (KA), quinolinic (QUIN). Particle-enhanced turbidimetric assay Enzyme-linked immunosorbent assays were used measure markers, hsCRP, IL-6, suPAR, NGAL sCD163. After applying Bonferroni corrections p =.05/3) adjusting for covariates (age sex), only G41 A55 groups was nearing significance higher levels QUIN compared S41 T55 groups, respectively (all =.023). Multiple regression results revealed that position 41 (adj 2 0.049, β 0.505; =.023), 55 0.126, 0.444; =.023) displayed significant associations after age sex. Lastly, observed group found be correlated suPAR r =.588, =.005). These collectively underscore importance substitutions influencing inflammation levels), potentially contributing our understanding their roles HIV-1.

Language: Английский

Citations

1
A Pilot Investigation of the Association Between Vpr Amino Acid Substitutions and Peripheral Immune Marker Levels in People With Human Immunodeficiency Virus: Implications for Neurocognitive Impairment DOI Creative Commons

Levanco K. Asia,

Esmé Jansen van Vuren, Iolanthé M. Kruger

et al.

Open Forum Infectious Diseases, Journal Year: 2024, Volume and Issue: 11(3)

Published: Feb. 27, 2024

Subtype-specific amino acid variations in viral proteins of human immunodeficiency virus type 1 (HIV-1) influence disease progression. Furthermore, Vpr sequence variation correlates with chronic inflammation, a central mechanism HIV-1 (neuro)pathogenesis. Nevertheless, no clinical study has investigated the link between and peripheral inflammation people HIV (PWH). The aim this pilot was to ascertain whether specific variants were associated immune markers PWH.

Language: Английский

Citations

1
The influence of viral protein R amino acid substitutions on clinical outcomes in people living with HIV: A systematic review DOI Creative Commons

Levanco K. Asia,

Esmé Jansen van Vuren, Monray E. Williams

et al.

European Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 53(5)

Published: Dec. 29, 2022

The HIV viral protein R (Vpr) is a multifunction involved in the pathophysiology of HIV-1. Recent evidence has suggested that Vpr amino acid substitutions influence HIV-1 and clinical outcomes people living with (PLWH). Several studies have linked to PLWH; however, there no clear consensus as which acids or are most important PLWH. We, therefore, conducted systematic review investigating PLWH.PubMed, Scopus Web Science databases were searched according PRISMA guidelines using search protocol designed specifically for this study.A total 22 included data extraction, comprising 14 cross-sectional 8 longitudinal studies. Results indicated associated specific outcomes, including disease progressions, neurological treatment status. Studies consistently showed substitution 63T was slower progression, whereas 77H 85P significant contribution progression.Vpr-specific may be contributors PLWH, future should consider highlighted review.

Language: Английский

Citations

6
Role of extracellular viral regulatory proteins in neuropathogenesis DOI
Michael R. Nonnemacher,

Rachel Berman,

Jill M. Lawrence

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 179 - 207

Published: Jan. 1, 2024

Language: Английский

Citations

0
The association between HIV-1 Tat and Vif amino acid sequence variation, inflammation and Trp-Kyn metabolism: an exploratory investigation DOI Creative Commons
Monray E. Williams,

Levanco K. Asia,

Jeremie Zander Lindeque

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 9, 2024

Language: Английский

Citations

0